Our faculty labs across all five divisions within the School bring together scientists and researchers from different backgrounds and varying specialties to advance knowledge and create solutions for the world’s biggest healthcare challenges.

Find and characterize new therapeutic targets and agents

jeff_aube

Jeff Aubé Lab

The Aubé laboratory uses synthetic chemistry to enable the study of biological pathways and as starting points for drug discovery.

albert_bowers

Albert Bowers Lab

Research in the Bowers Lab is concentrated on the synthesis, assessment, and modification of potential therapeutic leads, especially those derived from natural products.

david_drewry

David Drewry Lab

The Drewry lab in focused on designing, synthesizing, evaluating, and sharing small molecule chemical probes for protein kinases.

kevin_frankowski

Kevin Frankowski Lab

Research in the Frankowski lab uses synthetic chemistry to develop new approaches for the treatment of unmet medical needs.

stephen_frye

Stephen Frye Lab

The Frye lab focuses on chemical biology of chromatin regulation with an emphasis on proteins that bind methylated lysine, and collaborative oncology drug discovery with faculty in the Lineberger Cancer Center.

masuo_goto

Masuo Goto Lab

The Goto lab focuses on chemical biology of cell cycle regulation and multidrug-resistant phenotype in cancer using small molecules inspired by unique natural products.

nate_hathaway

Nate Hathaway Lab

The Hathaway lab was established at UNC with a founding idea that the group could make a contribution to understanding dynamic epigenetic processes by using unique chemical biology approaches they pioneered.

lindsey_ingerman_james

Lindsey Ingerman James Lab

The James lab is interested in modulating the activity of chromatin reader proteins with small-molecule ligands, specifically potent and selective chemical probes, in order to open new avenues of research in the field of chromatin biology and potentially translate to compounds of therapeutic value.

mike_jarstfer

Michael Jarstfer Lab

The Jarstfer lab is interested in targeting telomere biology for aging disorders and cancer treatment strategies and exploring the mechanism of oxytocin in controlling social behavior.

dimitri_kireev

Dmitri Kireev Lab

The Kireev lab develops and applies computational tools to advance our understanding of complex biological systems and discover therapies for unmet medical needs.

david_lawrence

David Lawrence Lab

The Lawrence lab works to understand the biochemical processes of the cell by studying them as they happen in the cell as opposed to studying them in vitro.

andrew_lee

Andrew Lee Lab

Andrew Lee studies the role of conformational dynamics in protein function, conformational changes, enzyme catalysis, drug binding, and allostery. His laboratory uses a variety of biophysical and biochemical tools, especially NMR spectroscopy.

jian_liu

Jian Liu Lab

Research in the Jian Liu group is focused on glycobiology and glycobiochemistry, an emerging field that emphasizes the biological functions of carbohydrates.

rihe_liu

Rihe Liu – Biological Therapeutics Lab

The Liu laboratory’s research interests focus on the development and application of novel drug target-binding affinity molecules by integrating directed molecular selection and evolution, ligand design and engineering, in vitro cellular and signaling characterization, and in vivo therapeutic efficacy studies in tumor mouse models.

robert_mcginty

Robert McGinty Lab

The McGinty lab studies molecular mechanisms of chromatin signaling. By pairing atomic precision protein chemistry with high resolution structural biology, they aim to understand how the nucleosome functions as a signaling hub for gene expression, DNA replication, and DNA damage repair in development and disease.

susan_natschke

Susan Morris-Natschke Lab

The Morris-Natschke laboratory focuses on natural product chemistry in collaboration with the Natural Products Research Laboratories at UNC.

kh_lee

Natural Products Research Laboratories

The K.H. Lee Natural Products Research Laboratories (NPRL) engage in research using medicinal chemistry-based methods to discover new drugs from herbal medicines, particularly Traditional Chinese Medicine.

samantha_pattenden

Samantha Pattenden Lab

The Pattenden lab develops innovative techniques in chromatin-based therapeutic target discovery and cancer diagnostics.

ken_pearce

Kenneth Pearce Lab

The Pearce lab utilizes numerous methods for conducting early drug and chemical probe discovery research.

bryan_roth

Bryan Roth Lab

Bryan Roth, PhD, MD, is a professor in the Division of Chemical Biology and Medicinal Chemistry and in the Department of Pharmacology.

alexander_tropsha

Alexander Tropsha Lab

Alexander Tropsha’s lab develops new methodologies, software tools and applications in the areas of computer-assisted drug design, chemical toxicology, materials informatics, text mining, and health care informatics.

xiaodong_wang

Xiaodong Wang Lab

The Wang lab is interested in developing drug leads/candidates for kinase, phosphate kinase and protein targets identified by UNC faculty and external investigators.

tim_willson

Tim Willson Lab

The Willson laboratory is home to the US site of the SGC, an open science consortium that accelerates research on the lesser studied regions of the genome.

Qisheng Zhang

Qisheng Zhang Lab

The Zhang lab studies lipid signaling pathways that are involved in human disease by developing novel chemical probes and technologies.

Learn more about Chemical Biology and Medicinal Chemistry

Deliver therapeutic agents for successful outcomes

kristy_ainslie

Kristy Ainslie Lab

Kristy Ainslie’s lab aims to design practical and innovative formulations, taking into account the scalable production and applications in developing nations.

aaron_anselmo

Aaron Anselmo Lab

The Anselmo lab focuses on understanding microbe-material-host tissue interactions to develop: (i) formulations for the improved delivery of therapeutic microbes, (ii) materials-based in vitro culture approaches to enable the co-culture of microbial ecologies alongside mammalian cells, and (iii) targeted approaches for the delivery of therapeutic microbes.

shawn_hingtgen

Shawn Hingtgen – Targeted Cellular Therapeutic and Imaging Lab

In the Hingtgen lab, we seek to harness the potential of stem cells to develop new and better methods for treating terminal cancers, including brain cancer. We use an integrative approach that begins with creating specially designed targeted therapeutic proteins.

leaf_huang

Leaf Huang – Laboratory of Drug Targeting

The Laboratory of Drug Targeting has been working on liposomes and immunoliposomes for drug delivery.

michael_jay

Michael Jay Lab

Jay’s research projects involve the development and commercialization of drug formulations and targeted delivery systems.

alexander_kabanov

Alexander Kabanov Lab

Alexander Kabanov is the director of the Center for Nanotechnology in Drug Delivery. The center’s research focuses on safely and efficiently translating new therapeutic and imaging agents from bench to bedside with the goal of improving human health.

sam_lai

Sam Lai – Lai Research Group

Research in the Lai Lab focuses broadly on infectious diseases at mucosal surfaces, targeted drug delivery and nanoparticle-immune interactions using a variety of tools from biophysics, molecular biology, immunology and engineering.

juliane_nguyen

Juliane Nguyen Lab

The Nguyen lab conducts research that focuses on the design and engineering of novel nano-scale carriers based on genetically encoded materials, lipids, and polymers for the treatment of ischemia.

Learn more about Pharmacoengineering and Molecular Pharmaceutics

Discover and evaluate the factors that influence how therapeutic agents work

kim_brouwer

Kim Brouwer Lab

Dr. Brouwer directs an NIH-funded research program focused on hepatobiliary drug disposition and development and refinement of in vitro model systems to predict in vivo hepatobiliary disposition, drug interactions, and hepatotoxicity.

Yanguang Cao Lab

Cao’s group is interested in developing system pharmacology platforms (models) integrating PK/PD to facilitate drug development and optimize therapeutics for cancers and autoimmune diseases.

Daniel_Crona

Daniel Crona Lab

His translational research program focuses on how genetic variations can lead to differences in the pharmacokinetics and pharmacodynamics of therapeutic treatments used in oncology, and how inter-individual differences in clinical pharmacology measures can affect survival and drug toxicity phenotypes.

julie_dumond

Julie Dumond Lab

Her primary research interest is the pharmacokinetics/pharmacodynamics of antiretrovirals.

Daniel_Gonzalez

Daniel Gonzalez Lab

His research interests include pediatric clinical pharmacology and the application of mathematical modeling and simulation techniques to characterize the pharmacokinetics and pharmacodynamics of drugs, guide dosage selection, and improve drug safety in children.

Erin_Heinzen

Erin Heinzen Lab

The Heinzen Lab focuses on the genetic and genomic basis of epilepsy disorders, including analyses of the role of germline mutations, somatic mutations, and how regulation of the cellular transcriptome influences the risk and presentation of seizures.

federico_innocenti

Federico Innocenti Lab

Dr. Innocenti’s NIH-funded research program is currently focused on the discovery of genomic determinants of efficacy and toxicity of cancer chemotherapy, integrating clinical genomic investigation with functional evaluation of gene variation.

Klarissa_Jackson

Klarissa Jackson Lab

Klarissa Jackson’s research interests focus on drug metabolism and toxicology to better understand the mechanisms and risk factors of adverse drug reactions and improve drug safety.

Angela_Kashuba

Angela Kashuba Lab

Dr. Kashuba’s research focuses on the clinical pharmacology of drugs used in the treatment, prevention, and cure of HIV infection.

Craig Lee Lab

His research focuses on cytochrome P450 metabolism, cardiovascular experimental therapeutics, and precision medicine/pharmacogenomics.

Gauri_Rao

Gauri Rao Lab

Rao’s principal research interests surround quantitative systems pharmacology, and she is working to understand the processes of infectious diseases.

dhiren_thakker

Dhiren Thakker Lab

Dhiren Thakker’s research focuses on drug absorption and metabolism.

Paul_Watkins

Paul Watkins – Institute for Drug Safety Sciences

The institute focuses on developing innovative approaches to investigate the underlying mechanisms of rare or “idiosyncratic” toxicities that are often not discovered until late in clinical development.

tim_wiltshire

Tim Wiltshire Lab

The Wilshire Lab’s research focuses on taking the pharmacogenetic knowledge we already have and develop approaches for that information to be used effectively in clinical practice.

william_zamboni

William Zamboni Lab

His research interests focus on the application of pharmacokinetic, pharmacodynamic, and pharmacogenetic principles in the optimization of the chemotherapeutic treatment of cancer.

Learn more about Pharmacotherapy and Experimental Therapeutics

Advance education and the practice of pharmacy

sachiko_ozawa

Sachiko Ozawa – GHEP Lab

The Global Health Economics for Pharmacy (GHEP) works to develop economic evidence for vaccines, medicines and pharmacy practice to save lives, improve quality of care and reduce poverty globally.

Jacqui McLaughlin – CIPhER

The Center for Innovative Pharmacy Education and Research works to improve the practice of pharmacy education and enhance the scholarship of and research on pharmacy education.

jon_easter

Jon Easter – CMO

The Center for Medication Optimization works to bring together healthcare stakeholders to create impactful real world research, generate evidence, disseminate best practices, and advance education that integrates medication optimization into value based care delivery and payment models.

Learn more about Practice Advancement and Clinical Education

Identify the health outcomes and value of therapies, policies and practices

susan_blalock

Susan Blalock Lab

Blalock’s work focuses on patient-provider communication concerning medication risks and the evaluation of community-pharmacy-based programs focused on illness prevention and disease management.

delesha_miller_carpenter

Delesha Carpenter Lab

Dr. Carpenter directs a funded research program that is focused in the areas ofpatient-provider communication, mobile and digital health, and rural health.

gang_fang

Gang Fang – ETrUOP Research Program

The ETrUOP Research Program is anchored on the research areas in Evaluating Treatment Utilization and Outcomes in Populations

Betsy_Sleath

Betsy Sleath Lab

Sleath’s research focuses on provider-patient communication in the areas of asthma, ADHD, diabetes, and glaucoma, engaging children and parents more in medication discussions during pediatric visits, and improving patient medication adherence and other health outcomes through interventions.

Dr. Roberts’ Lab

Dr. Roberts’ research focuses on evaluating and improving the implementation of genomic medicine. In particular, she is interested in conducting research to understand how precision medicine technologies can be implemented to improve access to, and reduce disparities in, high quality care and prevention.

Carolyn Thorpe Lab

Carolyn Thorpe, PhD, MPH is an associate professor in the Division of Pharmaceutical Outcomes and Policy. She conducts research to evaluate and improve prescribing quality and safety and medication adherence in older adults with multiple chronic conditions.

Alan Kinlaw Lab

Alan’s research focuses generally on pharmaco-epidemiology and health services research that leverages large and high-dimensional secondary data, including healthcare claims data, clinical registry data, and electronic health records.

Casey_Tak

Casey Tak Lab

Casey Tak’s research is primarily focused on women’s health, examining pharmaceutical and health services use in pregnancy/postpartum, and access to contraception.  He is also interested in the integration of pharmacists in clinical teams and the resulting patient and economic outcomes.

Joshua Niznik Lab

Dr. Niznik has developed expertise in pharmacoepidemiology, with skills in observational and quasi-experimental study designs, large database analyses, statistical approaches to minimize confounding in studies of medically complex older adults.

Elston Lafata Lab

The Elston Lafata Team is a diverse group of health care researchers, quality improvement leaders and analysts, students, and postdoctoral trainees. As a team, we work to understand how patient-provider communication and decision making affect the quality of healthcare delivered to and received by diverse populations of patients.

Scott Davis Lab

Dr. Davis’s lab is focused on the following areas: Improving patients’ ability to take their medications correctly to improve their outcomes; Implementing and evaluating the impact of quality improvement initiatives led by MAHEC, particularly in the area of maternal and child health; Improving mental health services in North Carolina and reducing health disparities by reducing barriers to mental health care access and utilization

Kathleen C Thomas Lab

We conduct research in behavioral economics to improve access to care, quality of care and outcomes for adults and children with mental health conditions. Our work is stakeholder engaged and uses a variety of data sources: primary and secondary data, electronic health records, claims, and other public records with input from stakeholders using interviews, focus groups and discrete choice experiments.

Learn more about Pharmaceutical Outcomes and Policy