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Shawn D Hingtgen

Clinical Assistant Professor Associate Professor

Shawn D Hingtgen, Ph.D.

Associate Professor, Division of Pharmacoengineering and Molecular Pharmaceutics

Associate Professor, Department of Neurosurgery, UNC School of Medicine


shawn_hingtgen

PHONE
(919) 537-3827
EMAIL
hingtgen@email.unc.edu
ADDRESS
4212 Marsico Hall, 125 Mason Farm Road, , Chapel Hill, NC, 27599
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Due to their expansive utility, stem cell-based therapies hold the potential to redefine therapeutic approaches and provide cures for many terminal diseases. In the Hingtgen lab, we seek to harness the potential of stem cells to develop new and better methods for treating terminal cancers, including brain, breast, lung, and others. We use an integrative approach that begins with creating specially designed targeted therapeutic proteins. We then “arm” different stem cell types with the anti-cancer molecules, and investigate the ability of stem cell-based therapies to improve both drug delivery and cancer cell killing using various small animal models of human cancer. Central to our research is the extensive integration of non-invasive imaging. We use multiple imaging modalities to provide real-time dynamic feedback on stem cell and tumor cell volumes and distribution, pharmacokinetics of drug delivery, and the overall effectiveness of our therapeutic approaches. By bringing together the tools and techniques of molecular biology, viral vectors, targeted therapeutics, stem cell biology, and molecular imaging with highly translatable animal models, we hope to ultimately bring successful cell-based treatments for multiple tumor types into the clinics.

 

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Twitter @HingtgenLab

Current Projects

  • Developing tumor-homing stem cell beacons for immune-based cancer therapy
  • Nanofiber matrices to improve neural stem cellmediated cancer therapy
  • Engineering stem cell therapies to understand and overcome glioblastoma adaption

2021 American Institute for Medical and Biological Engineering College of Fellows
2018 UNC Hettleman Prize for Scholarly and Artistic Achievement by Young Faculty
2014 Young Investigator Award, Society for Neuro-Oncology
2013 Finalist, The Damon Runyon-Rachleff Innovation Award
2010 Keystone Symposia Underrepresented Minority Scholarship
2008 American Brain Tumor Association Post-doctoral Research Fellowship
2005 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Minority Travel Award
2005 Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award
2004 College of Medicine Public Health Research Week Award
2004 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Minority Travel Award
2004 Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award
2003 New Investigator Award, Society for Free Radical Biology and Medicine
2003 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Minority Travel Award
2003 Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award
2002 Merck New Investigator Award
2001 Honorable Mention-James F. Jackobsen Forum
1994-98 Undergraduate Scholar Assistant
1994-98 Opportunity at Iowa Underrepresented Minority Scholarship



  • 1998 – 2004: Ph.D. at the University of Iowa
  • 1994 – 1998: BS in Biology at the University of Iowa