Delivering new methods of targeted drug delivery to optimize therapeutic efficacy of drugs and vaccines

stem cells

About DPMP

Pharmacoengineering and molecular pharmaceutics deals with delivering and maintaining the desired amount of a therapeutic agent at the target site for a desired period of time and with cell-based therapies. The development of a drug or vaccine delivery system that accomplishes this is based on an understanding of their transport properties across biological barriers and subsequent biodistribution as well as the mechanism by which they are metabolized and eliminated. These drug-delivery systems are tested in cell-based functional assays and/or human disease models in animals. As such, pharmacokinetic and pharmacodynamic assessments are the measure of performance of a given delivery system. The pharmacokinetics, be it at a subcellular/molecular level or an organ/tissue level, requires a sensitive and specific analytical method. Due to the interdisciplinary nature of research, most projects are in collaboration with colleagues of relevant expertise. The research currently being conducted by DPMP faculty and students involves improving the efficacy and delivery of a broad range of therapeutic agents, from small molecules to biologicals such as proteins, antibodies, oligonucleotides, genes, and cells.

Leaf HuangThere are many routes of administration, including oral, pulmonary, parenteral, percutaneous, and transmucosal. The design and fabrication of nanoparticulate drug carriers have received critical attention recently as they provide a new challenge as well as opportunities. Because of strong educational and training components in basic pharmaceutics, the division is ideally situated in bridging basic sciences to biomedical research. The Pharmacoengineering and Molecular Pharmaceutics program thus produces Ph.D.s who will eventually engineer drug delivery systems for new therapies and vaccines intended for human use. The majority of these Ph.D.s often find jobs in industry before graduation. Those who pursue an academic career usually spend a few more years as postdoctoral fellows at other institutions. During this period, they become independent investigators and refine their grantsmanship for future funding in academia. Whichever path they choose, our graduates have enjoyed outstanding employment throughout the history of the DPMP program.


If you would like to contribute to the FENG LIU STUDENT AWARD

Please visit the UNC Eshelman School of Pharmacy Foundation website at https://pharmacy.unc.edu/give/ways-to-give/

Or contact:

Office of Advancement and Alumni Affairs
UNC Eshelman School of Pharmacy
194 Finley Golf Course Rd., Suite 106 Chapel Hill, NC 27517
919.966.1929 (p) 919.843.9758 (f)

DPMP NEWS

  • Kabanov Elected to National Academy of Inventors

    Alexander “Sasha” Kabanov, Ph.D., Dr.Sc., Mescal Swaim Feruguson Distinguished Professor at the UNC Eshelman School of Pharmacy, has been named a Fellow of the National Academy of Inventors, the organization announced Tuesday. Kabanov is the director of the School’s Center … Continued

  • Kabanov Meets with President of Armenia

    Alexander “Sasha” Kabanov, Ph.D., met with the president of Armenia on Nov. 8 as part of a group of participants in the second All-Armenian Scientific Conference held in the capital city of Yerevan on November 5-8. The delegation consisted of … Continued


FAST FACTS

  • DPMP offers a strong pharmaceutics program with emphasis in drug-delivery science and technology. We also offer the Ph.D. in pharmaceutical sciences with an emphasis on pharmacoengineering, an emerging discipline that integrates engineering methods with pharmaceutical sciences.
  • The division features a distinguished faculty that includes  Alexander “Sasha” Kabanov, Ph.D., who joined the School in 2012 to lead the Center for Nanotechnology in Drug Delivery.
  • DPMP’s external research support exceeds $8.5M annually, mostly from the National Institutes of Health, but also from NSF, DoD, private foundations and the pharma/biotech industry.
  • There are currently 28 graduate students and 12 postdoctoral fellows in the program.
  • DPMP faculty have successfully spun off seven biotech companies in recent years.
  • The division added 24,500 square feet of research space in 2008.