Dr. Brouwer directs an NIH-funded research program focused on hepatobiliary drug disposition and development and refinement of in vitro model systems to predict in vivo hepatobiliary disposition, drug interactions, and hepatotoxicity. She is a co-inventor of B-CLEAR® (U.S. Patent No. 6,780,580), an in vitro method to assess hepatic uptake, excretion, and biliary clearance that correlates with in vivo data. This technology has been exclusively licensed from the University of North Carolina at Chapel Hill to Qualyst, Inc. Dr. Brouwer is a Qualyst founder and chairs the company’s scientific advisory board.

 

  • Brouwer, KR, Principal Investigator. UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program, sponsored by NIH/NIGMS.
  • Brouwer KR, Principal Investigator. Altered Hepatic Disposition of Anionic Drugs: Mechanism, sponsored by NIH.
  • Brouwer, KR, Consortium Principal Investigator. Human Cytochrome P450 4F Enzymes and Drug Interactions. Sponsored by NIH/NIGMS.
  • Brouwer, KR, Translational Science Advisory Board, Study Section Role: Member, Investigator North Carolina Translational & Clinical Sciences Institute (NC TraCS), sponsored by NIH.
  • Brouwer KR, Principal Investigator. Characterization of Hepatic Transporter Interactions with Tolvaptan and Metabolites Sponsored by Otsuka America Pharmaceutical, Inc.
  • Brouwer, KR, Subcontract Investigator. PhACTS (Physiologically Accurate Community-Based Framework for Training Systems) will provide a physiology research platform for distributed collaboration and consistent simulation. Sponsored by Applied Research Associates, Inc./Dept. of Defense.
  • Brouwer, KR, Subcontractor Co-Principal Investigator. Phase 1 Open-Label, Multiple Dose Study to Evaluate the Pharmacokinetics of TTP488. Sponsored by High Point Clinical Trials Center.
  • Brouwer, KR, Co-Investigator. UNC Clinical and Translational Science Award, sponsored by NIH.
  • Brouwer, KR, Co-Investigator. Short Course: Integrative and Organ Systems Pharmacology, sponsored by NIH.

 

Brouwer Lab 1

 

Kim L. R. Brouwer, Pharm.D., Ph.D.

(919) 962-7030

kbrouwer@unc.edu

Kim L.R. Brouwer, Pharm.D., Ph.D., is the William R. Kenan Jr. Distinguished Professor in the Division of Pharmacotherapy and Experimental Therapeutics of the UNC Eshelman School of Pharmacy, associate dean for research and graduate education, and a professor in the curriculum in toxicology.

Dong Fu, Ph.D.

(919) 962-5551

dongfu@email.unc.edu

Dong Fu, Ph.D., is a Research Assistant Professor in the Division of Pharmacotherapy and Experimental Therapeutics. His research interests are liver cell biology and hepatic pharmacology, especially, the cellular processes and the mechanisms that are related to hepatocyte polarization, hepatic transporters trafficking, bile acid signaling, drug-induced mitochondrial and hepatocellular injury and lipids metabolism in hepatocytes.

Lana Tran, Pharm.D.

(919) 962-0089

lanat@email.unc.edu

Lana Tran, PharmD., is a Clinical Research and Drug Development Fellow with the Division of Pharmacotherapy and Experimental Therapeutics. She is interested in hepatic transporter alterations in autosomal dominant polycystic kidney disease and the clinical implications in the disposition of medications that are known substrates of these transporters. She also works on pharmacokinetics/pharmacodynamics of antiretrovirals with a focus on gender, race, and aging effects.

James John Beaudoin, MS

(919) 966-5709

jbeaudoin@unc.edu

Jim Beaudoin, MS, is a graduate student in the Division of Pharmacotherapy and Experimental Therapeutics. Beaudoin’s research interests include pharmacogenomics, personalized drug therapy, drug toxicity, and drug transport

Jessica Murray, PharmD

(919) 999-9999

jessleem@live.unc.edu

Jessica Murray, PharmD, is a graduate student in the Division of Pharmacotherapy and Experimental Therapeutics.
Her research interests include studying the role of pharmacogenetics, drug metabolism, and drug transport in the development of adverse drug reactions.

Izna Ali, PharmD

(919) 962-1000

iznai1@email.unc.edu

Izna Ali, Pharm.D., is a graduate student in the Division of Pharmacotherapy and Experimental Therapeutics. Ali’s research interests include pharmacokinetics, pharmacometrics and the role of transporters in altered drug disposition.

Chitra Saran, M.S.

(919) 843-6960

saranch1@email.unc.edu

Chitra Saran is a graduate student in the Pharmacology Department at UNC School of Medicine. Chitra’s interests include studying mechanisms of hepatotoxicity, intracellular trafficking of drug transporters, CRISPR-Cas9, pharmacokinetics and drug disposition.

Jacqueline Bezencon, Ph.D.

(919) 962-0089

jackiebe@email.unc.edu

Jacqueline Bezençon, Ph.D., is a Postdoctoral Research Associate in the Division of Pharmacotherapy and Experimental Therapeutics. Her research interests are disease- and drug-mediated alterations in hepatic transport of drugs and endogenous compounds (e.g. bile acids) and its impact on drug disposition and toxicity.

Melina Malinen, Pharm.D., Ph.D.

(919) 962-0089

melinam@email.unc.edu

Melina Malinen, Pharm.D., Ph.D., is a Postdoctoral Research Associate in the Division of Pharmacotherapy and Experimental Therapeutics. Her research interests are hepatic drug and bile acid transport mechanisms and their role in drug induced liver injury (DILI) and nonalcoholic steatohepatitis (NASH). Especially, development of in vitro studies to characterize the effects of exogenous as well as endogenous compounds on the ADMET of drugs.

Noora Sjostedt, Ph.D.

(919) 962-0089

sjostedt@email.unc.edu

Noora Sjöstedt, Ph.D., is a Postdoctoral Research Associate in the Division of Pharmacotherapy and Experimental Therapeutics. Her research interests include understanding the role of transporters on pharmacokinetics, and the integration of in vitro and in silico methods to predict the transporter-mediated drug disposition and drug interactions.

Postdoctoral Fellows

NAME YEAR DEGREE CURRENT POSITION
Patricia Slattum 1992-1994 Pharm.D.Ph.D. Research Assistant Professor at Virginia Commonwealth University
Timothy P. Bradshaw 1992-1993 Ph.D. Project Manager, Clinical Operations at Pharmaceutical Product Development Inc.
David Taft 1993-1994 Ph.D. Dean, Pharmaceutics at Arnold & Marie Schwartz College
Arno Nolting 1995-1997 Ph.D. Senior Pharmacokineticist at Merck
Nita Patel 1998-2000 Ph.D. Senior Biochemical Pharmacologist at Eli Lilly and Company
Pieter Annaert 1998-2000 Ph.D. Assistant Professor at Catholic University of Leuven, Belgium
Yong-Hae Han 2001-2002 Ph.D. Research Scientist at Bristol-Myers Squibb Pharmaceutical Research Institute
Peijin Zhang 2000-2003 M.D.Ph.D. Senior Pharmacokineticist at Pharmacokinetics/Biostatistics, MPI Research
Ken-ichi Nezasa 2004-2005 Ph.D. Senior Scientist, DMPK, Shionogi Pharmaceuticals, Japan
Xianbin Tian 2003-2004 Ph.D. Principal Investigator, Archemix Corp.
Elaine Leslie 2004-2006 Ph.D. Assistant Professor of Physiology and Laboratory Medicine and Pathology, Membrane Protein Research Group, University of Alberta, Edmonton, Canada
Dan Bow 2006-2007 Ph.D. Senior Research Scientist, Abbott Laboratories
Mikko Koskinen 2007 Ph.D. Laboratory Manager, Orion Corporation ORION PHARMA
Koji Abe 2006-2008 Ph.D. Drug Metabolism and Pharmacokinetics, Sankyo Co., LTD, Japan
Kristina Wolf 2006-2009 Ph.D. Postdoctoral Fellow, UNC Eshelman School of Pharmacy
Wei Yue 2006-2007 Ph.D. Research Assistant Professor, UNC Eshelman School of Pharmacy
Betty Hussey 1987-1988 Pharm.D. Pharmacokineticist at GlaxoSmithKline
Patricia E. Warner 1991-1993 Pharm.D. Regional Medical Scientist, GlaxoSmithKline
Kellie L. Schoolar 1992-1994 Pharm.D. Pharmacokinetics Reviewer, FDA
Margaret R. Britto 1992-1994 Ph.D. Pharmacokineticist, Quintiles, Inc.
Katherine H.P. Moore 1993-1995 Pharm.D. Director, Clinical Pharmacokinetics of Antivirals, GlaxoSmithKline
Stephen P. Letrent 1993-1995 Pharm.D. Director, Clinical Oncology, Pfizer Global Research and Development
Mary Beth Mann 1994-1996 Pharm.D. Pharmacokineticist, GlaxoSmithKline
Elizabeth Migoya 1995-1997 Pharm.D. Clinical Associate, Merck Research Labs
Yazdi K. Pithavala 1995-1997 Ph.D. Pharmacokineticist, Agouron-Pfizer Global R&D
Jeffrey D. Fischer 1996-1998 Pharm.D. Director, Product Services and Support, Pharsight, Inc.
Joi Odishaw 1996-1998 Pharm.D. Director, Clinical Pharmacology, Infinity Pharmaceuticals
Kristine M. Radomski 1996-1998 Pharm.D. Assistant Professor, St. Jude Children’s Research Hospital
Paul Mudd 1997-1999 Pharm.D. Pharmacokineticist, GlaxoSmithKline
Min Song 1997-1999 Pharm.D. Pharmacokineticist, Pfizer, Inc.
Matthew Lamb 1998-2000 Pharm.D. Clinical Pharmacologist, Hoffman-La Roche
Chee Ng 1998-2000 Pharm.D. Director of Pharmacokinetics/Pharmacodynamics, Cancer Therapy and Research Center, San Antonio Cancer Institute
Bindu Murthy 1999-2001 Pharm.D. Manager Clinical Pharmacokinetics, Johnson&Johnson Pharmaceutical Research and Development
Daphne Williams 1999-2001 Ph.D. Senior Clinical Pharmacokineticist, GlaxoSmithKline
Susan Ford 2000-2002 Pharm.D. Pharmacokineticist, GlaxoSmithKline
Seth Berry 2000-2002 Pharm.D. Associate Research Pharmacokineticist, Clinical Pharmacology, Quintiles
Christine Brandquist 2001-2003 Pharm.D.M.S. Senior Scientist, Pharmacokinetics and Biopharmaceutics, GloboMax, ICON Consulting Medeval
Adam M. Persky 2002-2004 Ph.D. Clinical Associate Professor, University of North Carolina
Brendan M. Johnson 2003-2005 Ph.D. Pharmacokineticist, GlaxoSmithKline
Lakshmi Vasist 2004-2006 Pharm.D. Pharmacokineticist, GlaxoSmithKline
Todd Dumas 2004-2006 Pharm.D. Pharmacokineticist, Quintiles Inc.
Amar Mehta 2005-2007 Pharm.D. Law Student, Boston University
Grant Hogeland 2005-2007 Pharm.D. Pharmacokineticist, Quintiles, Inc.
Betty Ngo 2006-2008 Pharm.D. Pharmacokineticist, Quintiles, Inc.
Sandra Goss 2006-2008 Pharm.D.Ph.D. Pharmacokineticist, Abbott Laboratories
Ryan Criste 2007-2009 Pharm.D. Pharmacokineticist, MedImmune
Ahsan Rizwan 2008-2010 Ph.D. Research Scientist, Quintiles
Teodora Dumitrescu 2010-2012 Ph.D. Clinical Pharmacokineticist, Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline
 Vadryn Pierre  2014-2016  Pharm.D.  Staff Fellow – Clinical Pharmacology Reviewer at the FDA, CDER, OCP, Division V
 Stephen Greene  2016-2018  Pharm.D.  Clinical Pharmacology Manager, SK Life Science
 Josh Kaullen  2015-2017  Pharm.D.  Pharmacokineticist, IQVIA

 

 Graduate Students
James D. Whisnant 1999 M.S.
Scott D. Studenberg 1992 Ph.D. Senior Scientist, GlaxoSmithKline
A. Benjamin Suttle 1993 Ph.D. Research Pharmacokineticist, GlaxoSmithKline
Allen E. (Jo) Cato III 1994 Ph.D. Research Pharmacokineticist, Cato Research, Ltd.
Lisa Carlton 1995 Ph.D. Manager, Regulatory Affairs, Otsuka America Pharmaceuticals, Inc.
E. Stacy (Hall) Ward 1996 Ph.D. Research Scientist: Absorption Systems
Kenneth C. Turner 1996 Ph.D. Pharmacokineticist, Bristol-Myers Squibb Pharmaceutical Research Insistute
Kathryne Brewington 1997 Ph.D. Deceased
Catherine L. Booth 1998 Ph.D. Research Scientist, Merck Research Laboratories
Xingrong Liu 1998 Ph.D. Research Scientist, Roche Palo Alto
Stephen P. Letrent 1998 Pharm.D.Ph.D. Director, Clinical Oncology, Site Head for Oncology Translational Medicine and Clinical Leader for Signal Transduction in Oncology, Pfizer Global Research and Development
Hao Xiong 2001 Ph.D. Group Leader, Department of Clinical Pharmacokinetics, Abbott Laboratories
Chee Ng 2002 Pharm.D.Ph.D. Director of Pharmacokinetics/Pharmacodynamics, Cancer Therapy and Research Center, San Antonio Cancer Institute
Ryan Z. Turncliff 2004 Ph.D. Senior Scientist, Pharmacokinetics, Alkermes, Inc.
Keith A. Hoffmaster 2004 Ph.D. Novartis Institutes for BioMedical Research, Metabolism and Pharmacokinetics
Daniel C. Kemp 2004 Ph.D. Toxicology External Study Manager, GlaxoSmithKline
Priyamvada Chandra 2005 Ph.D. Novartis Institutes for BioMedical Research, Translational Sciences, DMPK PK/PD
Cornelia Smith 2005 Ph.D. Product Characterization Leader, CellzDirect, Inc.
Mary Peace McRae 2005 Ph.D. Assistant Professor, Department of Pharmacology, Kansas City University of Medicine and Biosciences
Maciej J. Zamek-Gliszczynski 2006 Ph.D. Senior Scientist, Eli Lilly and Company
Giulia Ghibellini 2006 Ph.D. Pharmacokineticist, ClinPharm Consulting
Patrick Roberts 2007 Ph.D. Postdoctoral Fellow, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Jin Kyung Lee 2009 Ph.D. Research Scientist, Qualyst, Inc.
Brandon Swift 2010 Ph.D. Pharmacokineticist, Allergan
Tracy Marion 2010 Ph.D.
Zhixia (Grace) Yan 2007-2011 Ph.D. Clinical Pharmacology Reviewer, FDA
LaToya Griffin 2006 – 2012 Ph.D. Academic Postdoctoral Fellow, Educational Technology Research and Development, University of North Carolina at Chapel Hill
Nathan Pfeifer 2008 – 2013 Pharm.D. Senior Clinical Pharmacokineticist II, AbbVie
Christina Mayer 2011 – 2013 Pharm.D. Scientist, Pharmacokinetics & Pharmacodynamics, Biologics Clinical Pharmacology, Janssen Research & Development
Mario Sampson 2011 – 2013 Ph.D. Pharmacokinetics Reviewer, Clinical Pharmacology, US FDA
Brian C. Ferslew 2009 – 2014 Ph.D. Scientist, Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, Theravance Biopharma
Curtis Johnston 2012 – 2014 Pharm.D. Pharmacometrics Bootcamp Scientist, Metrum Research Group LLC
Kyunghee Yang 2010 – 2014 Ph.D. Postdoctoral Fellow, Hamner-UNC Institute for Drug Safety Sciences
Jason Robert Slizgi 2012 – 2016 Ph.D.
Kevin Watt 2011-2017 Ph.D. Assistant Professor at Duke University School of Medicine, Department of Pediatrics
Cen Guo 2013-2018 Ph.D. Clinical Pharmacologist, Oncology, Pfizer

 

Visiting Scholars
Antti Kauttonnen 2017-2017 M.S.
Heeun Kang 2016-2017 Ph.D.
Katsuaki Ito 2016-2017 Ph.D.