Alexander Tropsha, PhD
  • Associate Dean for Research
  • K.H. Lee Distinguished Professor
  • Adjunct Professor of Biomedical Engineering
  • Adjunct Professor of Computer Science
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Alexander Tropsha, PhD

Research Synopsis

  • Development of new methodologies and software tools for computer-assisted drug design
  • Development of new approach to protein 3D structure analysis and prediction based on the principles of statistical geometry

Details of research at the Laboratory for Molecular Modeling

Profile

Alex Tropsha is an expert in the fields of computational chemistry, cheminformatics, and structural bioinformatics who works to develop new methodologies and software tools for computer-assisted drug design. He is creating new approaches to protein 3D structure analysis and prediction based on the principles of statistical geometry. His particular expertise lies in the field of cheminformatics, a discipline where information and informatics methodologies are applied to storing, managing, exploring, and exploiting chemical databases. In layman’s terms, cheminformatics combines chemistry and computer science to aid in the discovery of new drugs.

Tropsha has authored more than 125 peer-reviewed papers and twenty books and book chapters. He joined the School’s faculty in 1991 as an assistant professor and director of the Laboratory for Molecular Modeling. He was promoted to associate professor in 1997 and to full professor in 2004 and holds appointments as an adjunct professor in the UNC Department of Biomedical Engineering and in the Department of Computer Science and is a member of the UNC Lineberger Comprehensive Cancer Center. He was named as the  K. H. Lee Distinguished Professor in 2008.

As associate dean for research, Tropsha serves as the School’s chief research officer. He creates strategies to increase support for the research enterprise, oversees the School’s research centers, and works to cultivate and expand partnerships with entities within the University and with pharmaceutical and biotechnology companies.

Collaborators

Ivan Rusyn, Fred Wright, Bryan Roth

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