February 24, 2006
Kim Brouwer, PhD, has been selected to to participate in a working group of drug transporter biologists. The goal of the working group is to develop standards for transporter assays that can be used experimentally to study drug transporter interactions in the setting of the drug approval process.
Drug interactions with transporters in cellular assays are increasingly being studied during pre-clinical drug development. These studies are used in predictive absorption, distribution, metabolism and excretion (ADME) studies to predict pharmacokinetic properties and to select which drug among a set of candidate drugs to advance to clinical trials. Further, the studies are used to direct clinical drug-drug interaction studies.
Because of the increasing use of in vitro assays in the pre-clinical drug evaluation setting, the working group will develop reccomendations to standardized procedures for in vitro (cellular an/or membrane vesicle) assays.
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