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Reviews, Book Chapters, and Conference Proceedings

Clinical Protocols

1.            Nabel, G.J., Chang, A., Nabel, E.G., Plautz, G., Fox, B.A., Huang, L. and Shu, S. Immuno­therapy of malignancy by in vivo gene transfer into tumors.  Human Gene Therapy, 3:399-410, 1992.


Books Authored or Edited

1.            Huang L., Hung, M.C., Wagner, E. Nonviral Vectors for Gene Therapy.  Academic Press, 1999.

2.            Huang, L., Hung, M.C., Wagner, E. Nonviral Vectors for Gene Therapy. 2nd ed., Part I, Advances in Genetics, Vol. 53, Elsevier Academic Press, 2005.

3.            Huang, L., Hung, M.C., Wagner, E. Nonviral Vectors for Gene Therapy, 2nd ed., Part II, Advances in Genetics, Vol. 54, Elsevier Academic Press, 2005.


Reviews, Book Chapters and Conference Proceedings

1.            Huang, L. Liposome-cell interactions in vitro.  In: The Liposomes, Ed. Ostro, M., Marcel Dekker, chap. 3, pp. 87-124, 1983.

2.            Huang, L., Huang, A. and Kennel, S.J.  Coupling of antibodies with liposomes.  In: Liposome Technology, Vol. 3., Ed. Gregoriadis, G., CRC Press, Inc., chap. 4, pp. 51-62, 1984.

3.            Huang, A., Kennel, S.J. and Huang, L. Preparation of immunoliposomes.  In: Investigation of Membrane-Located Receptors. Eds. Reid, E., Cook, G.M.W. and Morr'e, D.J. Plenum Press, pp. 351-355, 1984.

4.            Huang, L. Liposomes as a new biotechnology: preparation and properties of liposomes. In:  Proceedings of the 1984 Symposium on Genetic Engineering and Biotechnology, Eds. Wu, R., Lin, E. and Kung, S.D. State Science and Technology Commission of the People's Republic of China, Beijing, pp. 447-454, 1984.

5.            Huang, L. Liposome-cell interactions in vitro and in vivo.  In: Proceedings of the 1984 Symposium on Genetic Engineering and Biotechnology, Eds. Wu, R., Lin, E. and Kung, S.D., State Science and Technology Commission of the People's Republic of China,  Beijing, pp. 455-462, 1984.

6.            Huang, L. Liposomes as diagnostic reagents and as vehicles for intracellular delivery of nucleic acids and proteins.  In: Proceedings of the 1984 Symposium on Genetic Engineering and Biotechnology, Eds. Wu, R., Lin, E. and Kung, S.D.  State Science and Technology Commission of the People's Republic of China, Beijing, pp. 463-473, 1984.

7.            Huang, L. Liposomes as Drug Carriers.  In: Proceedings of the 1984 Symposium on Genetic Engineering and Biotechnology, Eds. Wu, R., Lin, E. and Kung, S.D. StateScience and Technology Commission of the People's Republic of China, Beijing, pp. 474-480, 1984.

8.            Sullivan, S.M., Connor, J. and Huang, L. Immunoliposomes:  preparation, properties and applications.  Medicinal Research Reviews, Vol. 6, 171-195, 1986.

9.            Kabalka, G., Buonocore, E., Hubner, K., Huang, L.,  Moss, T. and Norley, N.  Gadolini­um labeled liposomes as contrast agents for magnetic resonance imaging. In: Contrast Agents in Magnetic Resonance Imaging, Eds. Runge, V.M., Claussen, C. and James, A.E.  Excerpta Medica Publ., pp. 88-91, 1986.

10.           Connor, J., Sullivan, S.M. and Huang, L. Monoclonal antibody and liposomes.  In: Monoclonal Antibodies in Pharmacology, a volume of International Encyclopedia of Pharmacology and Therapeutics, Eds. Fraser, C.M. and Venter, J.C. Pergamon Press, also published in Pharmacology and Therapeutics 28:341-365, 1985.

11.           Huang, L., Connor, J. and Wang, C.-Y.  pH-sensitive immunoliposomes.  In: Drug and Enzyme Targeting (volume 149 of Methods in Enzymology), Eds. Green, R. and Widder, K.J.  Academic Press, chap. 8, pp. 88-99, 1987.

12.           Connor, J. and Huang, L. Acid induced fusion of liposomes.  In: Cell Fusion, Ed. Sowers, A.E.  Plenum Publ. Co., chap. 13, pp. 285-299, 1988.

13.           Collins, D., Norley, S., Rouse, B. and Huang, L. Liposomes as carriers for antitumor and antiviral drugs: pH-sensitive immunoliposomes and sustained release immunoliposomes.  In: Liposomes as Drug Carriers:  Recent Trends and Progress, Ed. Gregoriadis, G., Wiley, chap. 55, pp. 761-770, 1988.

14.           Ho, R.J.Y. and Huang, L. Immunoliposome assays:  perspectives, progress and potential.  In: Liposomes as Drug Carriers: Recent Trends and Progress, Ed. Gregoriadis, G., Wiley, chap. 38, pp. 527-547, 1988.

15.           Collins, D. and Huang, L. Drug delivery by immunoliposomes.  In: Molecular Mechanisms of Membrane Fusion, Ed. Ohki, S., et al., Plenum Publishing Corp., pp. 149-161, 1988.

16.           Wright, S. and  Huang, L. Antibody directed liposomes as drug delivery vehicles, Advanced Drug Delivery Reviews 3:343-389, 1989.

17.           Holmberg, E. and Huang, L. pH-sensitive and target sensitive immunoliposomes for drug targeting.  In: Liposomes in the Therapy of Infectious Diseases and Cancer, Eds. Lopez-Berestein, G. and Fidler, I. Allen R. Liss, Inc., pp. 25-34, 1989.

18.           Huang, L. and Zhou, X.  Cytoplasmic delivery of DNA by pH-sensitive immunoliposomes.  In: Proceedings of ILRAD Workshop on Protein Traffic in Parasites and Mammalian Cells, pp. 81-86, 1989.

19.           Brynestad, K., Babbitt, B., Huang, L. and Rouse, B.T.  Liposomal peptide as a subunit vaccine.  In:  Therapeutic Peptides and Proteins:  Formulation, Delivery, and Targeting, Eds. Marshak, D. and Liu, D. Cold Spring Harbor Laboratory, pp. 99-106, 1990.

20.           Rouse, B.T., Kennel, S.J. and Huang, L. Drug delivery by immunoliposomes.  In: Proceedings of ILRAD Workshop on Chemotherapy of Trypanosomiasis, pp. 119-122, 1990.

21.           Maruyama, K., Kennel, S.J. and Huang, L. Liposomal drug delivery system,  Polymer Preprints 31:159-160, 1990.

22.           Maruyama, K., Kennel, S.J. and Huang, L. The target binding and retention of Stealth immunoliposomes.  J. Pharmacobio-Dyn., 14, s-32, 1991.

23.           Huang, L., Reddy, R., Nair, S., Zhou, F. and Rouse, B.T.  Liposomal delivery of soluble protein antigens for class I MHC mediated antigen presentation.  In: 41st Forum in Immunology, ed. van Rooijen, N., Research In Immunology 143:192-196, 1992.

24.           Zhou, X. and Huang, L. Targeted delivery of DNA by liposomes and polymers.  In: Proceedings of 5th International Symposium on Recent Advances in Drug Delivery Systems.  J. Controlled Release 19:269-274, 1992.

25.           Mori, A. and Huang, L. Immunoliposome targeting in a mouse model: optimization and therapeutic application.  In: Liposome Technology, Vol. 3, 2nd edition, Ed. Gregoriadis, G.  CRC Press, chap. 10, pp 153-162, 1992.

26.           Tari, A., Zhou, F. and Huang, L. Two types of pH-sensitive immunoliposome.  In: Liposome Technology, Vol. 3, 2nd edition, Ed. Gregoriadis, G. CRC Press, chap. 19, pp. 289-300, 1992.

27.           Pinnaduwage, P. and Huang, L. Target sensitive liposome for potential therapeutic applications.  In: Liposome Technology, Vol. 3, 2nd edition, Ed. Gregoriadis, G. CRC Press, chap. 18, pp. 277-287, 1992.

28.           Litzinger, D.C. and Huang, L. Phosphatidylethanolamine liposomes: drug delivery, gene transfer, and immunodiagnostic applications.  In: Biomembrane Reviews, Biochim. Biophys. Acta.  1113:201-227, 1992.

29.           Mori, A. and Huang, L. “Ninja liposomes” avoiding reticuloendothelial system: develop­ment and application.  Proceedings of First Shizuoka Drug Delivery System Symposium, University of Shizuoka, Japan.  Progress in Drug Delivery Systems 1:1-8, 1992.

30.           Pitt, B.R. and Huang, L. Targeted drug delivery to the lung. Contemp. Int. Med. 4:81-92, 1992.

31.           Mori, A., Liu, D. and Huang, L. Novel immunoliposome targeting system avoiding reticuloen­dothelial cell interactions.  In: Drug Targeting And Delivery:  Concepts In: Dosage Form Design, ed. Junginger, H. E., Ellis Horwood Publishers, pp. 26-42, 1992.

32.           Scherphof, G.L., Maruyama, K., van Borssum Waalkes, M., Hoekstra, D., Damen, J., Kennel, S.J. and Huang, L. Lipid flow phenomena between liposomes, lipoproteins and cell membranes: applications in drug delivery.  In: Liposome Dematics, eds. Braun-Falco, Korting and Maibach, Spring Verlag, pp. 11-19, 1992.

33.           Klibanov, A.L. and Huang, L. Long-circulating liposomes: development and perspectives.  J. Liposome Res. 2:321-334, 1992.

34.           Huang, L. Stealth liposomesTM, Ninja liposomes or cryptosomes: are they really sterically stabilized liposomes?  J. Liposome Res. 2:451-454, 1992.

35.           Huang, L. and Zhou, F.  Liposome and immunoliposome mediated delivery of proteins and peptides.  In:  Targeting of Drugs 3: The Challenge of Peptides and Proteins, eds. Gregoriadis, G., Allison, A.C. and Poste, G.  NATO Advance Study Institute Series,  Plenum., pp. 45-50, 1992.

36.           Gao, X. and Huang, L. Cationic liposomes and polymers for gene transfer.  J. Liposome Res. 3:17-30, 1993.

37.           Hofland, H. and Huang, L. Delivery of nucleic acid pharmaceuticals with liposomes. In:  Recent Advances in Pharmaceutical and Industrial Biotechnology, Ed. Duchene, D.  Proceedings of 6th International Pharmaceutical Technology Symposium, Ankara, Turkey, pp. 99-109, 1993.

38.           Son, K. and Huang, L. Liposomes for gene transfer.  In proceedings of 53rd INSERM Workshop on “Transfer of genes and antisense oligonucleotides: physiological and thera­peutic applications”, Le VJsinet, France, 1993.

39.           Torchilin, V.P., Zhou, F. and Huang, L. pH-sensitive liposomes.  J. Liposome Res.  3:201-255, 1993.

40.           Liu, D. and Huang, L. Immunoliposome targeting to pulmonary endothelium.  In: Drug Delivery Series, Vol. 2, Eds. Florence, A.T. and Gregoriadis, G. pp.111-124, 1993.

41.           Huang, L., Klibanov, A.L., Mori, A. and Gao, X.  Targeted delivery of drugs and DNA with liposomes.  Proceedings of conference on “Liposomes as biomimetics”, Rome, Italy, June 23-26, 1993.  J. Liposome Res.  3:505-515, 1993.

42.           Singhal, A. and Huang, L. Gene transfer in mammalian cells using liposomes as carriers.  In: Gene Therapeutics: Methods and Application of Direct Gene Transfer, Ed. Wolff, J.A., Birkhauser, pp. 118-142, 1994.

43.           Zhou, F. and Huang, L. Liposome-mediated cytoplasmic delivery of proteins:  an effective means to access the MHC class I-restricted antigen presentation pathway. ImmunoMethods  4:229-235, 1994.

44.           Singhal, A. and Huang, L. Direct gene transfer by liposomes.  Proceeding of The Liposome Conference In St. Petersburg:  New Concepts, Perspectives and Clinical Applications. J. Liposome Res. 4:289-299, 1994.

45.           Liu, D. and Huang, L. Interaction of pH-sensitive liposomes with blood components.  Proceedings of The Liposome Conference In St. Petersburg:  New Concepts, Perspectives and Clinical Applications.  J. Liposome Res. 4:121-141, 1994.

46.           Maruyama, K., Unezaki, S., Yuda, T. Ishida, O., Takahashi, N., Suginaka, A., Huang, L. and Iwatsuru, M.  Enhanced delivery and antitumor effect of doxorubicin encapsulated in long-circulating liposomes.  Proceedings of The Liposome Conference in St. Petersburg:  New Concepts, Perspectives and Clinical Applications.  J. Liposome Res. 4:143-165, 1994.

47.           Huang, L. Target-sensitive liposomes.  J. Liposome Res. 4:397-412, 1994.

48.           Huang, L. and Sorgi, F.L.  Comments:  Forum on “Liposomes in controlled release”.  J. Liposome Res. 4:439-440, 1994.

49.           Farhood, H., Gao, X., Son, K., Yang, Y.Y., Lazo, J.S., and Huang, L. Cationic liposomes for direct gene transfer in therapy of cancer and other diseases.  In: Annals of the New York Academy of Sciences, eds. Brian E. Huber and John S. Vol. 716, pp 23-35, 1994.

50.           Nabel, G.J., Nabel, E.G., Yang, Z., Fox, B.A., Plautz, G.E., Gao, X., Huang, L., Shu, S., Gordon, D., and Chang, A.E. Molecular genetic interventions for cancer. In: Molecular Genetics of Cancer. Cold Spring Harbor Laboratory Press, Vol. LIX pp 699-707, 1994.

51.           Singhal, A., and Huang, L. DC-chol liposomes as DNA carriers for gene therapy. In: Gene Therapy: From Basic Research To The Clinic, Ed. Kam M. Hui, World Scientific Publishing Co. Pte. Ltd., pp 107-129, 1994.

52.           Son, K. and Huang, L. Liposomal DNA delivery.  In:  Trends and Future Perspectives in Peptides and Protein Drug Delivery, Eds. Lee, V.H.L., Hashida, M. and Mizushima, Y. pp. 321-336, 1995.

53.           Hung, M.C., Matin, A., Zhang, Y., Xing, X., Sorgi, F., Huang, L. and Yu, D. HER-2/neu: targeting gene therapy. Gene 159:65-71, 1995.

54.           Zhou, F., and Huang, L. Delivery of protein antigen to major histocompatibility complex class-I-restricted antigen presentation pathway.  Journal of Drug Targeting 3:91-109, 1995.

55.           Mori, A., and Huang, L. Targeted immunoliposomes: potential role in the delivery of cytotoxic drugs. Clin. Immunother., 3 (3): 227-240, 1995.

56.           Goyal, K. and Huang, L. Gene therapy using DC-Chol liposomes. J. Liposome Res. 5 (1):49-60, 1995.

57.           Gao, X., and Huang, L. Cationic liposome mediated gene transfer. Gene Therapy  2:710-722, 1995.

58.           Bedu-Addo, F., and Huang, L. Interaction of PEG-phospholipid conjugates with phospholipid: Implications in liposomal drug delivery.  Advanced Drug Delivery Reviews  16:235-247, 1995.

59.           Yao, T., Huang, L. and Zern, M.A. The use of liposomes in the therapy of liver disease. Advanced Drug Delivery Reviews  17:239-246, 1995.

60.           Farhood, H., and Huang, L. Delivery of DNA, RNA, and proteins by cationic liposomes. In: Non-medical Use of Liposomes, Eds. Barenholz, Y. and Lasic, D.,CRC Press, Incorporated, pp 31-42, 1996.

61.           Li, S., Gao, X., Son, K., Sorgi, F. and Huang, L. DC-Chol lipid system in gene transfer. J. of Controlled Release 39:373-381, 1996.

62.           Lee, R.J. and Huang, L. Gene transfer by liposome-entrapped polycation-condensed DNA-LPDI and LPDII. Conference Proceedings, Artificial Self-Assembling Systems for Gene Delivery, American Chemical Society, Washington, D.C., eds. Felgner, Heller, Lehn, Behr and Szoka, Jr. chap. 16, pp 169-176, 1996.

63.           Li, S., and Huang, L. Lipidic supramolecular assemblies for gene transfer. J. Liposome Research 6:589-608, 1996.

64.           Li, S. and Huang, L. Targeted delivery of antisense oligodeoxynucleotides by LPD II. J. Liposome Research, 7:63-76, 1997.

65.           Deshmukh, H.M., and Huang, L. Liposome and polylysine mediated gene transfer. New J. of Chemistry, 21:113-124, 1997.

66.           Hara, T., Liu, F., Liu, D., and Huang, L. Emulsion formulations as a vector for gene delivery in vitro and in vivo. Advanced Drug Delivery Reviews 24:265-271, 1997.

67.           Son, K., Sorgi, F., Gao, X., Huang, L. Cationic liposome-mediated gene transfer to tumor cells in vitro and in vivo. In: Methods in Molecular Medicine, Gene Therapy Protocols; Ed. Robbins, P. Humana Press, chap. 23, pp. 329-337, 1997.

68.           Lee, R.J., and Huang, L. Lipidic vector systems for gene transfer. Critical Reviews in Therapeutic Drug Carrier Systems, 14(2) 173-206, 1997.

69.           Li, S., and Huang, L. Protamine sulfate provides enhanced and reproducible intravenous gene transfer by cationic liposome/DNA complex. J. Liposome Res., 7:207-219, 1997.

70.           Sorgi, F. L., and Huang, L. Drug delivery applications of liposomes containing non-bilayer forming phospholipids. In: Lipid Polymorphs and Membrane Properties.  In: Current Topics in Membranes, Volume 44. Ed. Epand, R. Academic Press Inc. chpt. 12, pp. 449-475, 1997.

71.           Lee, R., and Huang, L. pH-sensitive liposome-mediated macromolecule delivery into the cytoplasm of cultured cells. In: Cells: A Laboratory Manual, Eds. Spector, D., Goldman, R., and Lein-Wand, L., Cold Spring Harbor Laboratory Press, Vol. 2, chpt. 87, pp 87.1 - 87.9, 1997.

72.           Lee, R., and Huang, L. Delivery of DNA into mammalian cells using cationic liposomes. In: Cells: A Laboratory Manual, Eds. Spector, D., Goldman, R., and Lein-Wand, L., Cold Spring Harbor Laboratory Press, Vol. 2, chpt. 87, pp87.1 - 87.9,1997.

73.           Hofland, H.E.J., and Huang, L. Formulation and delivery of nucleic acids. In: Handbook of Experimental Pharmacology: Novel Therapeutics from Modern Biotechnology, Volume 137. eds. Oxender, D.L. and Post, L.E., Springer-Verlag, chpt.8, pp. 165-192, 1998.

74.           Brisson, M., and Huang, L. Improved gene delivery formulations and expression systems for enhanced transfection efficiency.  4th International Symposium on Bioorganic Chemistry. In: Pure & Appl. Chem.70 (1):83-88, 1998.

75.           Li, S., and Huang, L. Functional pleomorphism of liposomal gene delivery vectors: lipoplex and lipopolyplex. In: Liposomes: Rational Design, Ed. Janoff, A. Marcel Dekker, Inc., Chpt. 4, pp.89-124, 1999.

76.           Yang, J.P., and Huang, L. Novel supramolecular assemblies for gene delivery. In: Self-Assembling Complexes for Gene Delivery: from Chemistry to Clinical Trial., Ed. Kabanov, A., John Wiley Publishing. chpt 6, pp 117-134. 1998.

77.           Bhattacharya, S. and Huang, L. Cationic liposome-DNA complexes in gene therapy, In: Medical Applications of Liposome, Eds. Lasic, D.D. and Papahadjopoulous, D., Elsevier Press, chpt 5.3, pp. 371-394, 1998.

78.           Tseng, W.C. and Huang, L. Liposome based gene therapy. Pharm. Sci. & Tech. Today. 1 (5): 206-213, 1998.

79.           Chesnoy, S. and Huang, L. DNA condensed by polycations and lipids for gene transfer. S.T.P. Pharma Sciences. 9: 5-12, 1999.

80.           Brisson, M. and Huang, L. Liposomes: conquering the nuclear barrier.  Current Opinion in Molecular Therapeutics. 1(2): 140-146, 1999.

81.           Huang, L. and Viroonchatapan, E.  Introduction: Nonviral Vectors for Gene Therapy.  Ed. Huang, L., Hung, M.C., Wagner, E.  Academic Press, chpt 1, pp. 4-17, 1999.

82.           Li, S., and Huang, L. Novel Lipidic Vectors for Gene Transfer:  Nonviral Vectors for Gene Therapy, ed. Huang, L., Hung, M.C., Wagner, E.  Academic Press, chpt 13, pp. 290-306, 1999.

83.           Li, S. and Huang, L. Nonviral Gene Therapy:  Promises and Challenges, Millennium Review, Gene Therapy 7: 31-34, 2000.

84.           Chesnoy S, Huang, L. Structure and function of lipid-DNA complexes for gene delivery.  Annu. Rev. Biophys. Biomol. Struct.  29:27-47, 2000.

85.           Liu, F., Liang, K., Huang, L. Gene transfer to Skeletal Muscles via Systemic Administration of Plasmid DNA. Molecular Interventions. 1: 168-172, 2001.

86.           Liang, K. W. and Huang, L. New Lipid/DNA Complexes for Gene Delivery.  In: Polymeric Biomaterials: 2nd edition, Ed. Dumitriu, S., Marcel Dekker, pp. 929-958, 2002.

87.           Dileo, J. and Huang, L. Liposome Mediated Gene Therapy for Cancer.  Encyclopedia of Cancer, pp. 31-37, 2002.

88.           Tan, Y., Whitmore, M., Li, S., Frederik, P., and Huang, L. LPD Nanoparticles as a Novel Non-Viral Vector for Efficient Gene Delivery.  Ed. Morgan, J.R. Gene Therapy Protocols, 2nd edition, Humana Press, Inc.  chpt. 6, pp. 73-82, 2002.

89.           Nishikawa, M. and Huang, L. Nonviral Vectors in the New Millennium. Human Gene Therapy. 12: 861-870, 2001.

90.           Lui, V. and Huang, L. Non-Viral Approaches for Cancer Gene Therapy.  Pharmaceutical Gene Delivery Systems, Marcel Dekker, Inc.  131:  279-319, 2003.

91.           Liu, F. and Huang, L. Development of non-viral vectors for systemic gene delivery. Journal of Controlled Release. 78: 259-266, 2002.

92.           Li, S., Ma, Z., Tan, Y., Liu, F., Dileo, J. and Huang, L. Targeted Gene Delivery via Lipidic Vectors. In: Vector Targeting for Therapeutic Gene Delivery, Eds. Curiel, D. and Douglas, J., John Wiley & Sons, Inc. Chpt. 2. pp. 17-32, 2002.

93.           Tan, Y. and Huang, L. Overcoming the Inflammatory Toxicity of Cationic Gene Vectors. Journal of Drug Targeting. 2: 153-60, 2002.

94.           Liang, K., Liu, F. and Huang, L. Targeted gene delivery:  the role of peptide nucleic acid.  Letters in Peptide Science.  7:  161-167, 2004.

95.           Niidome, T. and Huang, L. Gene therapy progress and prospects: Non-viral vectors. Gene Therapy. 9: 1647-1652, 2002.

96.           Nishikawa, M., Huang, L., and Hashida, M. Dystrophin gene transfer for Duchenne Muscular Dystrophy.  Gene & Medicine. 6 (3): 389-394, 2002. (In Japanese).

97.           Dileo, J., Banerjee, R., Whitmore, M., Nayak, J., Falo, L., Huang, L. Lipid-Protamine-DNA-Mediated antigen delivery to antigen-presenting cells resulting in enhanced anti-tumor immune responses. Molecular Therapy.  7(5):  650-648, 2003.

98.           Banerjee, R. and Huang, L. Gene Therapy with Plasmid DNA. Burger’s Medicinal Chemistry and Drug Delivery 6th Edition.  Ed. Abraham, D.J.  John Wiley & Sons, Inc. Vol. 4 Chapter 13.  pp. 651-677, 2003.

99.           Zhang, J., Li, S., and Huang, L. Cationic liposome-protamine-DNA complexes for gene delivery, Methods in Enzymology.  Ed. Düzgünes, N. Elsevier Academic Press. V. 373 Liposomes Part C, pp. 332-341, 2003.

100.          Conwell, C. C. and Huang, L. Recent progress in nonviral gene delivery.  Non-viral gene therapy:  gene design and deliver.  Eds. Taira, K. and Kataoka K.  Springer-Verlag Tokyo Inc. Chapter 1. pp 3-10, 2005.

101.          Zhang, J-S., Liu, F., and Huang, L. Implications of pharmacokinetic behavior of lipoplex for its inflammatory toxicity. Advanced Drug Delivery Reviews.  pp. 689-962, 2005.

102.          Chen, W.S.C. and Huang, L. Non-viral Vector as Vaccine Carrier. In “Non-Viral Vectors for Gene therapy” 2nd ed., Eds. Huang, L., Huang, M.C. and Wagner, E. Advances In Genetics, Vol. 54: 316-338. Elsevier Inc. chapter 13, pp. 315-337, 2005.

103.          Conwell, C.C. and Huang, L. Recent Advances in non-viral gene delivery. In “Non-Viral Vectors for Gene Therapy” 2nd ed., Eds. Huang, L., Huang, M.C. and Wagner, E., Advances In Genetics, Vol. 53. Elsevier Inc. Chapter 1, pp. 3-18, 2005.

104.          Vangsseri, D., Han S-J., and Huang, L. Lipid-Protamine-DNA-Mediated Antigen Delivery. Current Drug Delivery. Bentham Science Publishers. 2(4): 401-406, 2005.

105.          Liang, K.W., Liu, F., and Huang, L. Targeted Gene Delivery: The Role of Peptide Nucleic Acid. In “Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules”, Eds, Janson, C. G., During, M. J. Medical Intelligence Unit. Landes Bioscience. Chapter 3, pp. 30-37, 2006.

106.          Banerjee, R and Huang, L. Vector System: Plasmid DNA. In “Encyclopedia of Molecular Cell Biology and Molecular Medicine 2nd Edition.” Ed. Meyers, R.A. Wiley-VCH Verlag GmbH & Co KgaA, Weinheim, Germany pp. 287 – 329, 2006.

107.          Tyagi, P., Wu. P.C., Chancellor, M., Yoshimura, N., Huang L. Recent Advances in Intravesical Drug/Gene Delivery. Molecular Pharmaceutics. 3:369-379, 2006. (PMCID: PMC2504416)

108.          Li, S., Huang, L. Gene Therapy Progress and Prospects: Non-viral Gene Therapy by Systemic Delivery. Gene Therapy.  13(18):1313-1319, 2006.

109.          Tyagi, P., Tyagi, S., Kaufman, J., Huang, L., and de Miguel, F.  Local Drug Delivery to Bladder Using Technology Innovations.  Urol Clin N Am 33:529-530, 2006.

110.          Li, S-D., Li, S., and Huang, L. Lipoplex and LPD Nanoparticles for In Vivo Gene Delivery. In “Gene Transfer. Delivery and Expression of DNA and RNA”, Eds, Friedman, T and Rossi J. Cold Spring Harbor Laboratory Press. Chapter 39, pp 433 – 438, 2006.

111.          Li, S-D. and Huang, L. Surface-Modified LPD Nanoparticles for Tumor Targeting. In “Oligonucleotide Therapeutics”. Annual of the New York Academy of Sciences 1082: 1 – 8, 2006.

112.          Shollenberger, L. M. and Huang, L. Liposome-Polycation-DNA: A Nonviral Gene Vector Turned into a Potent Vaccine Carrier. In “Liposome Technology: Entrapment of Drugs and Other Materials into Liposomes” 3rd Edition. Ed, Gregoriadis, G. Informa Healthcare USA, Inc. pp 245 – 252, 2007.

113.          Lee, P.-Y. and Huang, L. Non-viral vector systems. In Dr. Beverly Teicher’s Series “Gene Therapy for Cancer”; Eds. Hunt, K. K. Vorburger, S.A and Swisher, S.G. Humana Press Inc. pp.157-170, 2007.

114.          Yan, W. and Huang, L. Recent Advance in Liposome-based Nanoparticles for Antigen Delivery.  Polymer Reviews.  47:329 – 344, 2007.

115.          Li, S-D., and Huang, L. Non-viral is superior to viral gene delivery. Journal of Controlled Release. 123: 181-183, 2007.

116.          Li, S-D., and Huang, L. Pharmacokinetics and Biodistribution of Nanoparticles. Molecular Pharmaceutics 5(4): 496 – 504, 2008.

117.          Chen, Y., and Huang, L. Tumor Targeted Delivery of siRNA by Non-Viral Vector: Safe and Effective Cancer Therapy.  Expert Opin. Drug Deliv. 5 (12):1301-1311, 2008.

118.          Gao, K. and Huang, L. Non-viral Methods for siRNA Delivery. Molecular Pharmaceutics. 6: 651-658, 2009. (PMCID: PMC2692493)

119.          Li, S-D, and Huang, L. Targeted Delivery of siRNA by Nonviral Vectors: Lessons learned from recent advances.  Current Opinion in Investigational Drugs 9(12): 1317 – 1323, 2008.

120.          Tseng, Y-C., Mozumdar, S. and Huang, L. Lipid-based Systemic Delivery of siRNA.  Advanced Drug Delivery Reviews.  61(9):721 – 731, 2009.

121.          Bathula, S. R, and Huang, L.  Gene Therapy with Plasmid DNA. In “Burgers Medicinal Chemistry, Drug Discovery and Development.”  John Wiley & Sons. 2010.

122.          Vasievich, E.A., and Huang, L. Chemical Vectors for Delivery of Nucleic Acid-Based Drugs. In “Delivery Technologies for Biopharmaceuticals. Peptides, Proteins, Nucleic Acids and Vaccines.” Eds, Jorgensen, L., Nielsen, H.M.. John Wiley & Sons. Pp 69 – 92, 2009.

123.          Li, S.D. and Huang, L. Stealth Nanoparticles: High Density but Sheddable PEG Is a Key for Tumor Targeting. Journal of Controlled Release. 145(3):178-81, 2010. Epublication on Mar 23, 2010.

124.          Li, J. and Huang, L. Targeted Delivery of RNAi Therapeutics for Cancer Therapy. Nanomedicine, 5(10), 1483–1486, 2010.

125.          Sheng, W.Y. and Huang, L. Cancer Immunotherapy and Nanomedicine. Pharm. Res. 28(2):200-14, 2011. Published on line September 4, 2010.

126.          Zhang, Y. and Huang, L. RNA Drug Delivery Approaches. A chapter in “Drug Deliver in Oncology: From Research Concept to Cancer Therapy”, Volume 3, Eds. Kratz, F., Senter, P. and Steinhagen, H. Wiley-VCH, 2011.

127.          Vasievich, E. and Huang, L. The Suppressive Tumor Microenvironment:  A Challenge in Cancer Immunotherapy. Molecular Pharmaceutics. 8(3):635-41, 2011. Epub 2011 May 5.

128.          Huang, L. and Liu, Y. In Vivo Delivery of RNAi with Lipid-Based Nanoparticles. Annu. Rev. Biomed. Eng. 13:507-530. 2011. ePublication on May 31, 2011.

129.          Guo, S-T and Huang, L. Nanoparticles Escaping RES and Endosome: Challenges for siRNA Delivery for Cancer Therapy. Journal of Nanomaterials.  Special issue “Nanostructures for Medicine and Pharmaceuticals,” 2011.  JNM/742895.

130.          Guo, X. and Huang, L. Recent Advances in Non-viral Vectors for Gene Delivery. Accounts of Chemical Research. ePublication on August 26, 2011.

131.          Wang, Y.H. and Huang, L. Multifunctional Theranostic Nanoparticles for Brain Tumors. A commentary. Molecular Therapy, 20:10-11, 2012.

132.          Watson, D.S., Endsley, A.N. and Huang, L. Design considerations for liposomal vaccines: Influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens. Vaccine, 30(13):2256–2272, 2012. ePublication on February 2, 2012.

133.          Zhang, Y., Satterlee, A., and Huang, L. In vivo Gene Delivery by Non-viral Vectors: Overcoming Hurdles? Molecular Therapy. ePublication on April 24, 2012.

134.          Asai, T. and Huang, L. Nanoparticle-mediated RNA interference for cancer therapy. RNAi Therapeutics- Realizing Next Generation Pharmaceuticals, In press. 2012.

135.          Ramishetti, S. and Huang, L. Intelligent Design of Multifunctional Lipid Nanoparticle Platforms for Cancer Therapy. kit Lam, In press. 2012.

136.          Xu, Z. and Huang, L. Chemical vectors for gene delivery. A Chapter in "Gene Therapy: Technologies and Applications." Future Science Group. ePublication in press.

137.          Ramishetti, S. and Huang, L. Intelligent Design of Multifunctional Lipid Nanoparticle Platforms for Cancer Therapy. Therapeutic Delivery, 3(12):pp, 2012.

138.          Zhang, S. and Huang, L. Lipid Based Vectors for siRNA Delivery. Journal of Drug Targeting. In Press. 2012.


Editorials

1.            Huang, L. Journal of Liposome Research:  A Journal Born Again.  J. Liposome Res. 2(2), iii, 1992.

2.            Huang, L. Forum on “Liposomes in controlled release”.  J. Liposome Res. 4:327-330, 1994.

3.            Felgner, P.L., Barenholz, Y., Behr, J.P., Cheng, S.H., Cullis, P., Huang, L., Jessee, J.A., Seymour, L., Szoka, F., Thierry, A.R., Wagner, E. and Wu, G. Nomenclature for syn­thetic gene delivery system. Human Gene Therapy, 8:511-512, 1997.

4.            Li, S., and Huang, L. Liposomal gene delivery: a complex package. News and Views, Nature Biotechnology, 15:620-621, 1997.

5.            Huang, L. and Li, S. Introduction to Forum on “Intravenous delivery of genes”, J. Liposome Res.,7 (2-3) vii-xii, 1997.

6.            Huang, L. Introduction to Forum on “Liposomal Oligonucleotides” J. Liposome Res., 7 (1):vii-xi, 1997.

7.            Huang, L. “To target or not to target: That is the question” Introduction to Forum on “Liposome Targeting in Animal Models.” J. Liposome Research.  7 (4) ix-xii, 1997.

8.            Huang, L. “Journal of Liposome Research (1991-1997).”  Editorial. J. Liposome Res. 7(4) vii-viii, 1997.

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