Research Programs
RESEARCH PROGRAMS
UNC ORGAN INJURY BIOMARKER CORE
Our Focus
Cutting edge biomarkers that enable early detection and mechanistic insight of hepatic, renal and cardiac injury.
Our Approach
Vanguard of Discovery through participation in international consortia that discover, validate and qualify the newest and most promising biomarker candidates.
Innovative Methodologies advanced by identification of promising technologies for biomarker quantification and development of in-house expertise.
Advanced Analysis Tools via collaborations with the creators of innovative software designed to facilitate biomarker interpretation.
Please contact us for more information.
TRANSLATIONAL PHARMACOGENOMICS
Our Focus 
Novel in vitro and in vivo platforms coupled with a systems biology approach to identify mechanisms and risk factors associated with drug-induced liver injury.
Our Approach
Cutting Edge Nonclinical and Liver Culture Models coupled with the application of global profiling and high content methodology to identify early activation of stress response.
High-Impact Sponsored Projects to identify factors underlying human liver toxicity, explore the role of exosomes in drug-induced liver injury and validate a model for fibrosis.
Clinically Oriented Objectives to develop precision medicine strategies that mitigate the risk of drug-induced liver injury and to inform advances in the preclinical detection of human liver safety concerns.
Please contact us for more information.
THE DILI-SIM INITATIVE
Our Focus
Use of quantitative systems pharmacology modeling to improve patient safety, reduce the need for animal testing and reduce the costs and time
necessary to develop new drugs.
Our Approach
Stakeholder Support through a public-private partnership including scientists from academia, 12 major pharmaceutical companies and the FDA.
Development of Original Software such as DILIsym®, a mechanistic, mathematical model that can be used to understand and predict drug-induced liver injury in humans and preclinical species.
Constant Model Refinement to meet stakeholder needs and keep up to date with advances in the field.
Visit the DILI-Sim website or contact us for more information.