Karl M. Koshlap, PhD
NMR Facility Manager

Andrew Lee, PhD
Associate Professor

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NMR Facility

The NMR Facility at the UNC Eshelman School of Pharmacy serves the needs of research groups from across the campus of the University of North Carolina at Chapel Hill and beyond. The main facility in Kerr Hall houses Varian Inova 500, Inova 400, and Gemini 300 MHz spectrometers. A second 400 MHz (Varian 400MR) instrument is located at the satellite laboratory in the Genetic Medicine Building. The interests of the users are varied, and accordingly the laboratory has multiple capabilities for small molecule and natural product NMR, as well as macromolecular structure and dynamics.

NMR 2010

The Inova 400 and Gemini 300 spectrometers are used for routine 1H or 13C 1D experiments on a walk-up basis, or for simple 2D experiments (COSY, NOESY, HSQC, etc.).

The 500 MHz instrument is used for other nuclei (e.g. 31P or 19F), or for more advanced multi-dimensional, multi-nuclear experiments. It also has a wide variety of probes. This is a state-of-the-art instrument, with waveform generators on all four channels, and triple-axis gradients.

The 400MR in the Genetic Medicine Building is equipped with an SMS 100 sample changer and dual ProTune for automated operation. It is routinely used to obtain 1H, 13C, 31P, or 19F spectra, or to run the two-dimensional experiments typical for the study of small molecules.

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