Structural Genomics Consortium
The SGC (Structural Genomics Consortium) is a not-for-profit, public-private partnership that performs basic science of relevance to drug discovery. Our research is conducted at several sites around the world to produce reagents, proteins, antibodies, assays, and data that support exploration of the human genome. All material and intellectual output of the SGC is placed in the public domain for use without restriction.
The first SGC laboratory to operate in the USA is located in the UNC Eshelman School of Pharmacy at UNC Chapel Hill (SGC-UNC). The SGC-UNC laboratories were opened in the Summer of 2015 with generous support from the Eshelman Institute of Innovation and the University Cancer Research Fund.
The scientific focus of the SGC-UNC is the chemical biology of the dark proteome. Our scientists are working to create chemical inhibitors and screening assays to explore the biology of these understudied proteins from the human genome in health and disease. Scientists at the SGC-UNC are experts in medicinal chemistry, cell biology, and chemical biology. They are using these skills to develop small molecule inhibitors of dark proteins to be used in cells to reveal their biology. The main SGC-UNC research programs include:
- Develop chemical probes and NanoBRET assays for dark kinases in support of the Illuminating the Druggable Genome consortium
- Develop chemical probes for viral pathogens of pandemic potential for the READDI Antiviral Drug Discovery Center. In 2022, the National Institute of Allergy and Infectious Diseases, part of the NIH, awarded the UNC Eshelman School of Pharmacy more than $65 million to create the READDI-AViDD Center.
- Develop chemical probes to validate proteins associated with Alzheimer’s disease for the TREAT-AD consortium
Read more about SGC-UNC “Bringing the Dark Proteome Into the Light”
The SGC-UNC laboratories are located in the Genetic Medicine Building (GMB) on the UNC campus. Our street address is:
120 Mason Farm Road
GMB 1070H, CB#7356
Chapel Hill, NC 27599-7264