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The Promise of Academic Drug Discovery

Featuring former Center Director, Stephen Frye, PhD.

Project Proposals

The Center invites UNC faculty to contact Ken Pearce for an informal discussion of project opportunities.  The Center is a collaborative resource and does not operate on a fee for service or charge-back model. Projects of particular interest to the Center will be those for which there is good fit with the Center’s capabilities in chromatin science, assay development, compound profiling, medicinal chemistry, and a potential for joint funding. For formal collaborations, we will develop a detailed project plan. Collaboration with the Center will require execution of UNC’s Proposed Invention Income Distribution Plan (Intellectual Property Agreement), if creation of intellectual property is a goal. The Center has a therapeutic focus in oncology and a basic science focus in chromatin regulation. Projects that intersect with either of these areas would be of most interest.

General Criteria for Evaluation:

  • Disease relevance of target/pathway – oncology and chromatin focus
  • Potential scientific impact of small molecule tools
  • Tractability of assay development and ligand discovery
  • Portfolio balance and fit with center expertise
  • Funding status & prospects


Ken Pearce by email or by phone – 919-843-8461

Tool Compounds – Definition and Availability

Tool Compounds are small molecular weight compounds of known structure from the literature that are not commercially available. Tool Compounds are provided free to members of Lineberger Comprehensive Cancer Center (LCCC) for oncology related projects. For other faculty, we will obtain a price quotation for your review and approval.

To Request a Tool Compound from the Center please contact:

Jeff Aubé, PhD


Phone: (919) 966-9650




Citing the CICBDD

If the CICBDD provides tool compounds that are used in your publication(s) please do two things: cite the CICBDD and let us know about your success! Citing the CICBDD and reporting the citation will help keep the tool compounds from the CICBDD available to you.

Reporting the publication:

When reporting the citation please e-mail Dottie Forthman with the citation in the following format:

Authors, Title, PubMed reference.

Citing the CICBDD:

If significant consultation is provided by the CICBDD co-authorship may be appropriate. If the CICBDD provides compounds that are used in your publication please use this reference:

“Compound ‘X’ was generously provided by the Center for Integrative Chemical Biology and Drug Discovery (CICBDD) and the University Cancer Research Fund. The CICBDD is directed by Ken Pearce, PhD at the University of North Carolina at Chapel Hill. Tool compound provision is managed by Jeff Aubé, PhD, Professor in the CICBDD.”