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Administrative Contact:
Barbara Dearry

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Center for Integrative Chemical Biology and Drug Discovery

The Center for Integrative Chemical Biology and Drug Discovery was created with the mission of bringing dedicated medicinal chemistry expertise to bear on biological targets of therapeutic relevance under investigation by UNC faculty. Synthetic chemists, assay development and compound profiling scientists will work in the Center and create dedicated, multidisciplinary project teams with other groups on campus in order to progress targets through the drug discovery and development process.  The Center provides leadership of the North Carolina Comprehensive Chemical Biology Center, a member of NCI's Chemical Biology Consortium.

Research & Funding News

"Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1" published by Perfetti et al. online in ACS Chemical Biology, January 15, 2015.

Stephen Frye and CICBDD featured in the University Gazette October 29, 2014.  Read More  See Video

Center receives $3 million to support research through a gift to the School of Pharmacy from Dr. Fred Eshelman.  More

Center collaborator J. Coghill, MD, awarded translational research grant from the Leukemia & Lymphoma Society.  Read More

The Center has moved into the newly opened Marsico Hall at 125 Mason Farm Road, Chapel Hill, NC 27599-7363. More

"UNC 2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor" published by W. Zhang et al., J. Med. Chem. 2014 57, 7031-7041.

"The Lipid Kinase PIP5K1C Regulates Pain Signaling and Sensitization" published in Neuron, 82 (4) 836-847 with Collaborator Mark Zylka and team. 

A Chemical Tool for in vitro and in vivo Precipitation of the Lysine Methyltransferase G9a published by Jin group and collaborators in ChemMedChem, 2014, DOI: 10.1002/cmdc.201300450.  View inside cover image by Kyle Konze and Samantha Pattenden.


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