What is Pharmacometrics?

Pharmacometrics is the science of understanding and mathematically describing drug action and variability in the body, including:

  • Pharmacokinetics: the time course of drugs
  • Pharmacodynamics: the effects of drugs over time

The Pharmacometrics Core is equipped to assist investigators at each step in the pharmacokinetic/pharmacodynamic research process, from study design and data analysis to publication.

Services

Services include pharmacokinetic/pharmacodynamic study design, optimal sampling schemes, pharmacokinetic data analysis, including noncompartmental and compartmental approaches, pharmacokinetic/pharmacodynamic modeling, pharmacologic data interpretation, data preparation for presentation or publication, and assistance in locating analytical resources on the UNC-CH campus.

Eligible Users

UNC and other academic investigators, as well as government and commercial investigators as permitted

Mission & Goals

The mission of the Pharmacometrics Core is to provide the research community of UNC and the state of North Carolina with support for the design, conduct, and analysis of pharmacokinetic (the time course of drugs) and pharmacodynamic (the effects of drugs over time) studies. Our goal is to provide expert consultation to improve drug therapy, from pre-clinical animal models to healthy volunteers and patients.

Director

Julie Dumond, Pharm.D., M.S.

(919) 966-5017

jdumond@unc.edu

Julie Dumond, Pharm.D., M.S., is an assistant professor in the Division of Pharmacotherapy and Experimental Therapeutics. Her primary research interest is the pharmacokinetics/pharmacodynamics of antiretrovirals. She is currently conducting a clinical study in aging, HIV-infected subjects to explore the effects of cellular aging and frailty on antiretroviral toxicity and efficacy.