April 25, 2006
Tim Wigle, a graduate student in the Division of Medicinal Chemistry and Natural Products, has won a 2006 Impact Recognition Award. The awards, sponsored by the UNC Graduate Education Advancement Board, recognize graduate students whose research provides special benefits to the citizens of North Carolina.
In 2004, tens of thousands of North Carolinians acquired antibiotic resistant infections that led to more than 1,000 unnecessary deaths and cost the state’s health care system nearly $1 billion. Wigle’s research, in the laboratory of Professor Scott Singleton, focuses on a bacterial protein called RecA, which may facilitate the development and spread of antibiotic resistance. Wigle is looking for ways to prevent activation of RecA or interfere with the activated form of RecA in an effort to decrease the incidence of antibiotic resistance infections. He has already identified some inhibitors that can be used as leads for the design of pharmaceutics and as important chemical biology toolsets to probe RecA further.
“It is an honor to be acknowledged for the work that I have done so far and I think it just goes to show the level of high quality research impacting the health care field that takes place at the School of Pharmacy,” said Wigle.
The Impact Award winners, along with members of the Royster Society of Fellows, act as graduate student ambassadors, talking to community groups throughout the state about their work.
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