The current research focus of Tim Wiltshire, Ph.D., centers on the translation of pharmacogenetic information and testing into clinical practice, and preclinical pharmacogenetics using mouse models.
Wiltshire received a B.S. in organic chemistry from the University of Canterbury in New Zealand and then went on to become certified as a high school teacher. He taught high school for a number of years in New Zealand and then made a career change and come to the U.S. to pursue a Ph.D. He received his Ph.D. in biochemistry and cell and molecular biology from the University of Tennessee and then went on to postdoctoral research positions at the Johns Hopkins School of Medicine and the University of Pennsylvania. He joined the Genomics Institute of the Novartis Research Foundation as a scientist and over eight years became a senior research investigator there. The main direction of his research was identifying mouse models of disease, genetics and genomics, and a focus on developing genomics resources (SNPs, gene expression and genetic analysis methods). The major theme of this work was to identify novel drug targets for the Novartis drug-discovery pipeline.
Wiltshire is now an associate professor in the Division of Pharmacotherapy and Experimental Therapeutics and Director of the UNC Center for Pharmacogenomics and Individualized Therapy. He also holds adjunct faculty positions in the Department of Genetics of the UNC School of Medicine and the UNC Lineberger Comprehensive Cancer Center and is actively involved with multiple collaborations with other Institutions. The major focus of his laboratory and CPIT is to take the pharmacogenetic knowledge we already have and develop approaches for that information to be used effectively in clinical practice.
- Ph.D. in Biochemistry and Cell and Molecular Biology, University of Tennessee
- B.S. in Organic Chemistry, University of Canterbury, New Zealand