William Janzen

Adjunct Professor of the Practice Director, Assay Development and Compound Profiling

Publications

  • Wright, B.D., Loo, L., Street, S.E., Ma, A., Taylor-Blake, B., Stashko, M.A., Jin, J., Janzen, W.P., Frye, S.V. and Zylka, M.J. (2014) The Lipid Kinase PIP5K1C Regulates Pain Signaling and Sensitization. Neuron, 82, 836-847.
  • Peterson, E. J., D. Kireev, A. F. Moon, M. Midon, W. P. Janzen, A. Pingoud, L. C. Pedersen, and S. F. Singleton.. Inhibitors of Streptococcus pneumoniae Surface Endonuclease EndA Discovered by High-Throughput Screening Using a PicoGreen Fluorescence Assay. J Biomol Screen. 2013;18(3):247-57. Epub 2012/09/28. doi: 10.1177/1087057112461153. PubMed PMID: 23015019.
  • Liu, J., W. Zhang, M. A. Stashko, D. Deryckere, C. T. Cummings, D. Hunter, C. Yang, C. N. Jayakody, N. Cheng, C. Simpson, J. Norris-Drouin, S. Sather, D. Kireev, W. P. Janzen, H. S. Earp, D. K. Graham, S. V. Frye, and X. Wang.  UNC1062, a new and potent Mer inhibitor. Eur J Med Chem. 2013;65C:83-93. Epub 2013/05/23. doi: 10.1016/j.ejmech.2013.03.035. PubMed PMID: 23693152.
  • Christoph, S., D. Deryckere, J. Schlegel, J. K. Frazer, L. A. Batchelor, A. Y. Trakhimets, S. Sather, D. M. Hunter, C. Cummings, J. Liu, C. Yang, D. Kireev, C. Simpson, J. Norris-Drouin, E. A. Hull-Ryde, W. P. Janzen, G. L. Johnson, X. Wang, S. V. P. D. Frye, H. S. Earp, 3rd, and D. K. Graham. 2013. UNC569, a novel small molecule Mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Mol Cancer Ther:molcanther. 0040.2013.
  • James, L. I., V. K. Korboukh, L. Krichevsky, B. M. Baughman, J. M. Herold, J. L. Norris, J. Jin, D. B. Kireev, W. P. Janzen, C. H. Arrowsmith, and S. V. Frye. 2013. Small-Molecule Ligands of Methyl-Lysine Binding Proteins: Optimization of Selectivity for L3MBTL3. Journal of Medicinal Chemistry:130916112320003.
  • Camerino MA, Zhong N, Dong A, Dickson BM, James LI, Baughman BM, Norris JL, Kireev DB, Janzen WP, Arrowsmith CH. The structure–activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface. MedChemComm. 2013;4(11):1501-7.
  • Liu F, Barsyte-Lovejoy D, Li F, Xiong Y, Korboukh V, Huang XP, Allali-Hassani A, Janzen WP, Roth BL, Frye SV, Arrowsmith CH, Brown PJ, Vedadi M, Jin J. Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP. J Med Chem. 2013. doi: 10.1021/jm401480r. PubMed PMID: 24102134.
  • Zhang W, Zhang D, Stashko MA, Deryckere D, Hunter D, Kireev D, Miley MJ, Cummings C, Lee M, Norris-Drouin J, Stewart WM, Sather S, Zhou Y, Kirkpatrick G, Machius M, Janzen WP, Earp HS, Graham DK, Frye SV, Wang X. Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors. J Med Chem. 2013. doi: 10.1021/jm401387j. PubMed PMID: 24195762.
  • Lee S-K, Cheng N, Hull-Ryde E, Potempa M, Schiffer CA, Janzen WP, Swanstrom R. A Sensitive Assay Using a Native Protein Substrate For Screening HIV-1 Maturation Inhibitors Targeting the Protease Cleavage Site between Matrix and Capsid. Biochemistry. 2013;52(29):4929-40. doi: Doi 10.1021/Bi4005232. PubMed PMID: WOS:000322416800006.
  • Cheng N, Lee SK, Donover PS, Reichman M, Schiffer CA, Hull-Ryde EA, Swanstrom R, Janzen WP. Development of a Novel Screening Strategy Designed to Discover a New Class of HIV Drugs. J Lab Autom. 2013:2211068213513453. doi: 10.1177/2211068213513453. PubMed PMID: 24305957