December 14, 2005
Researchers at the University of North Carolina at Chapel Hill have found evidence that many second-generation antidepressants, despite differences in drug classification and cost, offer patients very similar benefits and only minimal differences in risks.
Second-generation antidepressants include selective serotonin reuptake inhibitors (SSRIs) and other drugs that selectively affect the activity of neurotransmitters. A paper published in the Annals of Internal Medicine, led by Richard A. Hansen, PhD, assistant professor in the School of Pharmacy , examined the effects of ten commonly prescribed second-generation antidepressants, including Prozac, Zoloft, Wellbutrin , and Paxil . The study examined the role of these medications in the initial treatment of adult patients with major depressive disorder.
“Past studies have compared the effectiveness of second-generation antidepressants with that of placebo or older treatments, but have not systematically evaluated how the second-generation agents compared to each other,” said Hansen. “Given the number of second-generation treatments available, cost differences, widespread use, and the general lack of consensus in how the drugs compare, our research helps patients, clinicians and policy makers decide which drug is best.”
After comparing the effects of second-generation antidepressants in forty-six controlled trials, Hansen and his research group determined that these medications do not offer substantial differences in the treatment of major depressive disorder.
“Comparative evidence on these drugs suggests that there are only minimal differences in efficacy, although some of the drugs come with an increased risk of certain side effects,” said Hansen. “Understanding the likelihood of these side effects and matching this information with patient’s lifestyle and preferences may help improve drug treatment of depression.”
For additional information please visit:
http://www.annals.org/cgi/content/abstract/143/6/415
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