Research
CBMC has research strengths in the synthesis and structure-activity characterization of pharmaceutically relevant small molecules and natural products; bioorganic and chemical biology studies of the properties of designed small-molecule ligands and their cognate drug targets, including proteins, nucleic acids, and glycoconjugates; combinatorial biochemistry and proteomics for the identification of novel signaling pathways and drug targets; structural biology and biomolecular dynamics of drug-protein interactions; chemo- and bioinformatics; and molecular modeling.
Importantly, our scientific interests are integrated with the University of North Carolina’s extensive presence in the biomedical sciences. These interests also benefit from many pharmaceutical research programs in nearby Research Triangle Park. In keeping with the spirit of drug discovery that exists in North Carolina’s Research Triangle, the UNC Eshelman School of Pharmacy is a campus-wide leader in new scientific inventions.
With modern, sophisticated instrumentation in place, CBMC is well equipped to support this robust research program.
- High-resolution liquids NMR facility (400 MhZ and 500 MHz spectrometers)
- Digital imaging and photodocumentation equipment
- Phosphorimaging
- Molecular graphics workstations
- Scintillation and gamma counters
- Microplate readers and automated liquid handling devices for HTS
- Steady- and transient-state spectrofluorimetry
- Tissue culture
- HPLC and FPLC devices
- Combinatorial synthesis and automated purification
- Oligonucleotide Synthesis Cores (2)
- Protein Synthesis/Sequencing Cores (2)
- DNA Sequencing Core
- Tissue Culture Core
- Flow Cytometry Core
- Structural Biology Core
- Mass Spectrometry Core
- Digital Video Microscopy Core
- Transgenic and Homologous Recombination Core
- Molecular Modeling / Computer Graphics Core
- Macromolecular Interactions Facility
Center for Integrative Chemical Biology and Drug Discovery
The CICBDD is a multi-disciplinary group that provides an innovative and sustainable scientific force in the creation of chemical probes, drug candidates, assay technologies, and computational approaches to advance understanding of biological mechanisms and place UNC at the forefront of translational medicine. Additionally, the CICBDD serves to help train students and postdoctoral fellows to enable development of the next generation of drug discovery scientists.
Natural Products Research Laboratories
The NPRL team engages in research using medicinal chemistry-based methods to discover new drugs from herbal medicine, particularly Traditional Chinese Medicine.
Structural Genomics Consortium
The SGC team of scientists is dedicated to discovering and openly sharing selective, small molecule inhibitors of protein kinases.