Skip to main content

Sean O'Byrne

Post-Doc Research Associate

Sean O’Byrne


(919) 962-5349
120 Mason Farm Road, , , Chapel Hill, NC, 27599

Sean is a medicinal chemist with a keen interest in the synthesis and applications of protein inhibitors and activity-based probes to elucidate drug targets and identify therapeutic opportunities. He has extensive experience in route design, multistep synthesis, purification and characterization of complex small molecules, as well as expertise in the design and synthesis of BODIPY fluorescent dyes. During his PhD research in the University of Glasgow, he worked on two distinct projects. He developed an effective anti-parasitic drug delivery system which selectively targets infected host cells. His second project involved the synthesis of self-reporting activity-based probes for kinases, allowing for detection of covalent bond formation between proteins and ligands.