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Philip Smith

Associate Professor Administrative Director Vice Department Chair

Philip Smith, Ph.D.

Vice Chair, Division of Pharmacoengineering and Molecular Pharmaceutics

Associate Professor, Division of Pharmacoengineering and Molecular Pharmaceutics


(919) 962-0095
1309 Kerr Hall, , CB# 7571, Chapel Hill, NC, 27599-7571

Dr. Smith received a B.S. in Pharmacy from the University of Illinois, Chicago Medical Center, and then a Ph.D. in Pharmaceutical Chemistry, with an emphasis in pharmacokinetics, in 1985 from the University of California, San Francisco. After postdoctoral studies at the National Institutes of Health in Bethesda, MD, as a National Research Council Fellow, he joined the faculty of the College of Pharmacy at the University of Texas at Austin. In 1992 he moved to the School of Pharmacy at the University of North Carolina at Chapel Hill where he is presently Associate Professor and Vice Chair of the Division of Pharmacoengineering and Molecular Pharmaceutics. Dr. Smith’s main research efforts are directed toward establishing quantitative methods for proteins associated with drug disposition, understanding factors influencing the disposition, pharmacokinetics, reactivity and potential toxicity of labile acyl glucuronide metabolites, the role of glucuronidation in intestinal toxicity of drugs and the modulation of drug glucuronidation by botanicals/herbal remedies. He is Director of the Quantitative Targeted Proteomics Laboratory which utilizes LC-MS for protein measurements in complex matrices. He is past recipient of the Faculty Development Award in Pharmacology and Toxicology from the PhRMA Foundation.   Dr. Smith was Co-Chair of the 1997 ISSX meeting and is currently an ISSX Council Member for North America.  He serves as an ad hoc reviewer for NIH study sections and as a consultant to the pharmaceutical industry. Dr. Smith participates as a reviewer for the journals Drug Metabolism and Disposition, Biochemical Pharmacology, Pharmaceutical Research, the Journal of Pharmaceutical Sciences and others.

ORCID iD: 0000-0003-2102-1209

Education, Certification and Licensure

  • 1978 – 1985: Ph.D. in Pharmaceutical Chemistry at University of California
  • 1974 – 1978: B.S. in Pharmacy, Honors, 12/77 at University of Illinois
  • 1973 – 1974: Northern Illinois University

Current Projects

  • Lilly QTAP of Transporter Proteins in Hepatocytes of Five Species
  • Lilly QTAP of Transporter Proteins in KO Mice and Rats
  • Lilly QTAP of UGTs/P450/CES/Transporters in Intestinal Microsomes and Hepatocytes
  • Quantitative Targeted Proteomic Analysis (QTAP) of Human Microsomes for ADME Screening
  • Regulation of Hepatic P450s by anti-Cholesterol Drugs
  • Targeted Quantitative Proteomics Analysis of Transporters, including OAT2/7 in Human Hepatocytes

Honors and Awards

2003 Edward Kidder Graham Award for Undergraduate Studies and Teaching, UNC Chapel Hill
1990 – 93 Faculty Development Award in Pharmacology/Toxicology, Pharmaceutical Manufacturers Association Foundation
1986 – 88 National Research Council Fellow, National Institute for Child Health and Human Development
1985 – 88 Halls-Shields Fellow, National Cancer Institute
1980 – 83 Merck Pharmaceutics Fellow, American Foundation for Pharmaceutical Education
1977 Rho Chi Society