Leaf Huang received his Ph.D. in biophysics at Michigan State University. He was previously at the University of Tennessee, Knoxville (1976–1991) and at the University of Pittsburgh (1991–2005) as a faculty member. In July 2005, he was appointed as a Fred Eshelman Distinguished Professor at UNC Eshelman School of Pharmacy and chair the Division of Molecular Pharmaceutics, a position he held until 2012.
Huang has published over 320 peer-reviewed articles, over 120 invited reviews/book chapters, and has co-edited two books. The Laboratory of Drug Targeting has been working on liposomes and immunoliposomes for drug delivery. Current activities are focused in the development of nonviral vectors for gene (including siRNA) therapy, and receptor mediated drug and vaccine targeting using self-assembled nanoparticles. The technologies are tested for therapy of cancer and liver diseases in animal models.