David Lawrence works to understand the biochemical processes of the cell by studying them as they happen in the cell as opposed to studying them in vitro. He currently focuses on applying his discoveries to cancer detection and treatment and, to a more limited extent, inflammatory diseases. Lawrence is a Fred Eshelman Distinguished Professor of Medicinal Chemistry and holds joint appointments in the Department of Chemistry and the Department of Pharmacology and is a member of the UNC Lineberger Comprehensive Cancer Center. Before joining the School in 2007, Lawrence spent eleven years as a professor of biochemistry at the Albert Einstein College of Medicine at Yeshiva University in New York. Before that, he was at the State University of New York at Buffalo for ten years.
Living cells have been referred to as the test tubes of the 21st century. The creation of molecules that inhibit, probe, or alter the biochemistry of the cell lies at the nexus of chemistry and biology. The field of Chemical Biology seeks to correlate the underlying chemistry of life with the behavior of cells, tissues, and organisms. By revealing the nature of the molecular engine that drives cellular behavior Chemical Biology provides the molecular foundation upon which innovative therapies can be created for the entire spectrum of human afflictions.
The Lawrence research program is multifaceted, encompassing the fields of organic and peptide synthesis, photochemistry, enzymology, molecular and cell biology, and microscopy. This research team is engaged in the synthesis, characterization, and cell-based application of light-responsive agents (inhibitors, sensors, activators, proteins, and gene expression system), which are designed to manipulate and probe the biochemical pathways that control cell behavior. Disease states under investigation include cancer, disorders of metabolism, and inflammatory diseases.
Education, Certification and Licensure
1976 BS in Biological Sciences, University of California at Irvine
1982 PhD in Organic Synthesis, University of California at Los Angeles
Research Director: Professor Robert V. Stevens
1982 to 1985, NIH Postdoctoral Fellow in Bio-Organic Chemistry, The Rockefeller University
Research Director: Professor E. Thomas Kaiser
- Thomas A. Shell, Jennifer R. Shell, Zachary L. Rodgers, and David S. Lawrence “Tunable Visible and Near IR Photoactivation of Light-Responsive Compounds” Angewandte Chemie International Edition in English, 2014, 53, 875 -8. Received VIP designation.
- Luong T. Nguyen, Nancy L. Allbritton, and David S. Lawrence “Lipid Pools as “Photolabile Protecting Groups”: Design of Light-Activatable Bioagents”Angewandte Chemie International Edition in English, 2013, 52, 9936 – 9. Received VIP designation.
- Jennifer R. Shell and David S. Lawrence “Probes of Mitochondrial cAMP-Dependent Protein Kinase” Biochim. Biophys. Acta 2013, 1834, 1359 – 63.
- Ryan M. Phillips, Eric Bair, David S. Lawrence, Christopher E. Sims, and Nancy L. Allbritton “Measurement of Protein Tyrosine Phosphatase Activity in Single Cells by Capillary Electrophoresis” Analytical Chemistry, 2013, 85, 6136 – 42.
- Daniel R. Larson, Christoph Fritzsch, Liang Sun, Xiuhau Meng, David Lawrence, and Robert H. Singer “Light-Activated Receptor-Mediated Transcription in Single Cells”, eLife, 2013, 2: e00750.
- Finith Jernigan and David S. Lawrence “A Broad Spectrum Dark Quencher: Construction of Multiple Colour Protease and Photolytic Sensors” Chemical Communications, 2013, 49, 6728 – 30.
- Qunzhao Wang and David S. Lawrence “Multicolor Visualization of Protein Arginine Deiminase-Catalyzed Citrullination”, Angewandte Chemie International Edition in English, 2013, 52, 2323 – 5.
- Weichen Xu, Nancy L. Allbritton, and David S. Lawrence “Src Kinase Regulation in Progressively Invasive Cancer”, PLoS One, 2012, 7, e48867.
- Angela Proctor, Qunzhao Wang, David S. Lawrence, and Nancy L. Allbritton “Development of a peptidase-resistant substrate for single-cell measurement of protein kinase B activation”, Analytical Chemistry, 2012, 84, 7195 – 202.
- Shen Zhang, Lan Chen, L., David S. Lawrence, and Zhong-Yin Zhang. “A combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors”, Methods in Molecular Biology, 2012, 928, 53 – 65.