Daniel Gonzalez, Pharm.D., Ph.D.
Associate Professor
Adjunct Assistant Professor, Pediatrics
PHONE(919) 966-9984
daniel.gonzalez@unc.edu
ADDRESS
Kerr Hall, Room 2402, 301 Pharmacy Lane, CB #7569, Chapel Hill, NC, 27599-7569
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Daniel Gonzalez, Pharm.D., Ph.D., is an associate professor in the Division of Pharmacotherapy and Experimental Therapeutics of the UNC Eshelman School of Pharmacy. He has an adjunct appointment within the Department of Pediatrics in the UNC School of Medicine. He joined the UNC Eshelman School of Pharmacy in 2014 after completing a postdoctoral fellowship through the UNC-Duke Collaborative Clinical Pharmacology T32 Postdoctoral Training Program. Gonzalez received his Pharm.D. and Ph.D. from the University of Florida College of Pharmacy in 2008 and 2012, respectively. Gonzalez is a licensed pharmacist in North Carolina and Florida.
Gonzalez’s experiences have afforded a highly collaborative and multidisciplinary research program focused on advancing pediatric public health by promoting the safe, effective, and individualized use of drugs in children. His research interests include pediatric clinical pharmacology and the application of mathematical modeling and simulation techniques to characterize the pharmacokinetics and pharmacodynamics of drugs, guide drug dosage selection, and improve drug safety in children. Gonzalez’s research program is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and he has published >90 peer-reviewed publications and >40 abstracts. He has served as the major advisor for 6 PhD students, 14 postdoctoral fellows, and 2 professional degree students.
The overall objective of Dr. Daniel Gonzalez’s research program is to optimize pharmacotherapeutic efficacy and safety through the use of clinical and experimental data, and the application of mathematical modeling and simulation techniques, with an emphasis in pediatric populations. This is first accomplished by characterizing the differences in pharmacokinetic (PK) and pharmacodynamic (PD) relationships across human development, elucidating and quantifying influential factors of drug disposition, and the degree of interindividual variability surrounding them. Assessment of such changes are then related to deviations in drug effects and overall patient outcomes. With such characterizations established, optimal dosing regimens are derived, with a clinical impact in patient populations for which evidence-based dosing recommendations are frequently absent.
The Gonzalez Lab is currently focused on research in the following areas:
- Characterizing drug pharmacokinetics/pharmacodynamics in the pediatric population
- Studying the effect of obesity on pharmacokinetics and drug dosing in children and adolescents
- Evaluating drug-drug interactions in the pediatric population
- Use of real-world data to evaluate drug safety and efficacy
- Drug dosing individualization
Please click here for a list of Dr. Gonzalez’s publications.
Dr. Gonzalez directs a National Institutes of Health (NIH)-funded research program focused on the application of population and physiologically-based pharmacokinetic/pharmacodynamic modeling and simulation techniques to characterize drug disposition and effects, guide dosage selection, and improve drug safety in the pediatric population. Through application of these techniques, the Gonzalez Lab seeks to optimally design clinical trials, understand the mechanistic underpinnings that affect drug disposition and effects with age and body size, and account for patient factors that contribute to pharmacokinetic/pharmacodynamic variability in children.
Learn More About the Gonzalez Lab
- Postdoctoral Fellowship, UNC/Duke T32 Clinical Pharmacology Program
- Ph.D., College of Pharmacy, University of Florida
- Pharm.D., College of Pharmacy, University of Florida
Daniel Gonzalez News
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Daniel Gonzalez, Pharm.D., Ph.D., receives ASCPT Early Investigator Award
UNC Eshelman School of Pharmacy’s Daniel Gonzalez, Pharm.D., Ph.D., is the recipient of the 2023 Leon I. Goldberg Early Investigator Award. Established in 1986, the annual award honors young scientists for accomplishments in the field of clinical pharmacology early in … Continued
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U.S. Food and Drug Administration updates label on children’s seizure medication after UNC, Duke study provides pharmacokinetic, dosing data
A Pediatric Trials Network pharmacokinetics study led by researchers at the UNC Eshelman School of Pharmacy and Duke University recently contributed to a medication label change for the drug diazepam, commonly used to treat seizures in children. This research effort, Population … Continued
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Daniel Gonzalez aims to characterize drug-drug interactions in infants with a five-year grant totaling $2.3 million
With the support of a five-year National Institutes of Health grant totaling $2,323,160, Daniel Gonzalez, Pharm.D., Ph.D., will work to characterize drug-drug interactions in infants. Dedicated pharmacokinetic drug-drug interaction studies are performed in healthy adult volunteers during drug development. However, … Continued
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Daniel Gonzalez promoted to associate professor in Division of Pharmacotherapy and Experimental Therapeutics
Daniel Gonzalez, Pharm.D., Ph.D., has been promoted to associate professor in the Division of Pharmacotherapy and Experimental Therapeutics at the UNC Eshelman School of Pharmacy, effective June 1. “I routinely reflect on how lucky I am to be a faculty … Continued
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Jackie Gerhart Wins BAHM Case Competition
Jackie Gerhart, a Ph.D. student at the UNC Eshelman School of Pharmacy, took first place at the Business School Alliance for Health Management Case Competition at Harvard Business School on Feb. 9. Gerhart and her partner, Aditi Borde, a dual … Continued
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Gonzalez Receives $2M NIH Grant for Project on Childhood Obesity
Daniel Gonzalez, Pharm.D., Ph.D., an assistant professor at the UNC Eshelman School of Pharmacy in the Division of Pharmacotherapy and Experimental Therapeutics, received a $2 million NIH Research Project Grant for research focused on drug dosing in children with obesity. Gonzalez’s … Continued
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Gerhart Receives 2018 ASCPT Presidential Trainee Award
Jacqueline “Jackie” Gerhart, M.S., a first-year doctoral student in the Division of Pharmacotherapy and Experimental Therapeutics, has received the 2018 American Society for Clinical Pharmacology and Therapeutics Presidential Trainee Award. The $500 award recognizes the top-scoring abstracts that were submitted … Continued
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UNC and Duke Researchers Collaborate to Predict Drug Safety in Preemies
A research duo from UNC Eshelman School of Pharmacy and Duke University has received a $50,000 grant to develop a new method for predicting drug safety in pediatric patients. The award is part of an effort by the neighboring Clinical … Continued