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The Eleventh Annual Chapel Hill Pharmaceutical Sciences Conference

At The Carolina Inn, Chapel Hill, NC
The conference will focus on various aspects of precision medicine, including the use of pharmacogenomics, novel pharmacologic and phenotypic approaches, and quantitative clinical pharmacology in drug treatment individualization; as well as the implementation of precision medicine findings.

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7:30 – 8:15 AM Registration and Breakfast
8:15 – 8:30 AM Welcome from Dean Bob Blouin and Associate Dean Kim Brouwer

ACPE#0046-0000-17-044-L04-P (2.75 hours)

Session 1: Pharmacogenomics in Precision Medicine

8:30 – 9:00 AM
Regulatory Perspective on Precision Medicine

Objectives:

  • Provide a general overview of the regulatory aspects related to use of biomarkers to achieve precision medicine.
  • Discuss more specifically the regulatory landscape of genetic biomarkers of drug response.
Lawrence Lesko, PhD, FCP

Clinical Professor and Director, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida

9:00 – 9:45 AM
How to Interpret Patient Genotyping Data (Part 1)

Objectives:

  • Provide meeting participants genotyping data for the actionable pharmacogenome.
  • Discuss case studies to illustrate the process of how to interpret pharmacogenetics testing for pharmacists and its clinical impact.
  • Provide a panel discussion of the application of pharmacogenetics testing for cancer, pain management, and cardiovascular disease today.
Tim Wiltshire, PhD

Director, Center for Pharmacogenomics and Individualized Therapy;
Associate Professor, Division of Pharmacotherapy and Experimental Therapeutics
UNC Eshelman School of Pharmacy

9:45 – 10:00 AM
Break
10:00 – 10:30 AM
How to Interpret Patient Genotyping Data (Part 2: Case Studies)
Daniel Crona, PharmD, PhD

Assistant Professor, DPET, UNC Eshelman School of Pharmacy

Craig Lee, PharmD, PhD

Associate Professor, DPET, UNC Eshelman School of Pharmacy

DPET – Division of Pharmacotherapy and Experimental Therapeutics

PACE – Division of Practice Advancement and Clinical Education

10:30 – 11:00 AM
How to Interpret Patient Genotyping Data (Part 3: Panel Discussion)
 Daniel Crona, PharmD, PhD
Craig Lee, PharmD, PhD
John Valgus, PharmD, MHA, BCOP
Jon Easter, BSPharm
Amber Proctor, PharmD
11:00 – 11:30 AM
Implementation of Genetic Information within an Institutional Setting

Objective:

  • Describe practical implementation at the institutional level (example of best practices).
Alan Shuldiner, MD

Vice President of Translational Genetics, Regeneron Pharmaceuticals, Inc.

11:30 AM – 12:30 PM
Lunch

ACPE# 0046-0000-17-045-L04-P (4.0 hours)

Session 2: Novel Pharmacologic and Phenotypic Approaches to Precision Medicine

12:30 – 1:00 PM
T-Cell Engineering for the Treatment of Cancer

Objective:

  • Provide an introduction to the use of Individualized T cell engineering as a novel therapeutic strategy for the treatment of malignancies.
Barbara Savoldo, MD, PhD

Professor, Immunology, Virology, Pediatrics Hematology-Oncology, UNC-Chapel Hill

1:00 – 1:30 PM
The Role of the Gastrointestinal Microbiome in Precision Medicine

Objective:

  • Describe the influence of the gut microbiome on individual drug response, and highlight new technologies in this emerging field of study.
Lawrence David, PhD

Assistant Professor, Center for Genomic and Computational Biology, Duke University

1:30 – 2:00 PM
Integration of Pharmacometabolomics into Precision Medicine

Objective:

  • Describe recent advances in pharmacometabolomics, and discuss how it’s being used to complement pharmacogenomics for individualized drug therapy.
Rima Kaddurah-Daouk, PhD

Director, Pharmacometabolomics Research Center, Duke University
Professor, Psychiatry and Behavioral Sciences, Medicine, Duke University

2:00 – 2:30 PM
Speaker Panel Discussion
2:30 – 2:45 PM
Break

Session 3: Role of Quantitative Clinical Pharmacology in Delivering Precision Medicine

2:45 – 3:00 PM
Role of Adaptive Feedback Control in Precision Medicine

Objective:

  • Discuss the roles of adaptive feedback control in delivering precision medicine.
Alan Forrest, PharmD

Clinical Professor, DPET, UNC Eshelman School of Pharmacy

3:00 – 3:30 PM
Innovative Tools and Applications to Adaptive Feedback Control

Objective:

  • Provide examples of innovative tools and applications to adaptive feedback control.
David D’Argenio, PhD

Professor, Biomedical Engineering, USC Viterbi School of Engineering

3:30 – 4:00 PM
Applications of Adaptive Feedback Control in the Pediatric Population

Objective:

  • Present an overview of the applications of adaptive feedback control in the pediatric population.
Michael Neely, MD, MSc, FCP

Director, Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute

4:00 – 4:30 PM
Regulatory Perspective on Implementing Adaptive Feedback Control in Drug Development

Objective:

  • Provide a regulatory perspective of the challenges and opportunities to implementing adaptive feedback control in drug development.
Philip Colangelo, PharmD, PhD

Clinical Pharmacology Team Leader, Office of Translational Sciences, U.S. Food and Drug Administration

Evening Session: Cocktails, Hors d’oeuvres, and Science

5:30 – 7:30 PM Poster Session and Evening Cocktails/Hors d’oeuvres
6:00 – 6:30 PM
Guided poster tour, two posters within each grouping (six total)
  • 10-minute presentation with 5 minutes for questions.

Learning Objectives:

  1. Disseminate ongoing research across therapeutic areas
  2. Stimulate opportunities for future collaboration within and beyond The School of Pharmacy

Advance professional development of trainees in methods of scientific presentation.

7:15 – 8:00 AM Registration and Breakfast

ACPE# 0046-0000-17-046-L04-P (4.25 hours)

Session 4: Implementing Precision Therapy

Main Content: Precision medicine is an innovative medical model that takes into account individual variability in genes, environment, and lifestyle for each person. This “customization of healthcare” is one of the “biggest of the big data problems”.

At the conclusion of each knowledge based session, participants should be able to:

  1. Assess and understand broadly the current state of precision therapy.
  2. Describe the developing opportunities/strategies for precision therapy to leverage collaborations with academic and the non-academic partners.
  3. Discuss new opportunities/strategies that should be pursued in Precision Therapy at UNC, and in North Carolina.

Questions to Address:

  • What is the current state of precision therapy?
  • What are the immediate opportunities for precision therapy?
  • What is the future of precision medicine?
  • Where should precision medicine be headed at UNC?
8:15 – 8:30 AM
Welcome and Introduction

Objective:

  • Summarize events from Day 1.
Daniel Gonzalez PharmD, PhD, and/or, Tim Wiltshire PhD (Conference Co-Chairs)
8:30 – 9:15 AM
Plenary Lecture: “Imprecision Medicine”

Objective:

  • Define what we are and aren’t doing right in precision medicine.
Nick Schork, PhD

Director of Bioinformatics and Biostatistics; Professor, Department of Molecular and Experimental Medicine, The Scripps Research Institute

9:15 – 10:15 AM
Presentations: The Future of Precision Therapy from three perspectives

Presenters (3 areas for 20 minute presentations)


Pharmaceutical Industry
Arlene Hughes

Genomic Medicine Senior Director, PAREXEL International


Technology Industry
Fah Sathirapongsasuti, PhD

Computational Biologist, 23andMe


Health Care Payers
Jon Easter, BSPharm

Director, Center for Medication Optimization through Practice and Policy (CMOPP)

UNC Eshelman School of Pharmacy

10:30 – 11:30 AM
Panel Discussion

Objectives:

Panel presenters, plenary speakers and closing speaker will discuss the following in a panel format.

  1. What are the strategies and barriers?
  2. What technology should we be using?
  3. What can we transfer from other disciplines (disciplines/stakeholders as well as Academia, Clinical, Industry (Pharmaceutical and Technology), Payers, and Regulatory)?
11:30 AM – 12:00 PM
Closing Plenary: Vision for Precision Medicine at UNC

Objective:

  • Discuss the current state and vision for precision medicine initiatives at UNC-Chapel Hill.
Terry Magnuson, PhD

Vice Chancellor for Research, UNC-Chapel Hill

12:00 – 12:15 PM
Closing of Conference: Associate Dean Kim Brouwer

Comprehensive pharmacogenetic testing will be offered to all participants. Continuing education credit will be offered for licensed pharmacists. Abstracts focused on precision medicine research will be accepted.

ACPElogoThe University Of North Carolina Eshelman School Of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. The program ACPE# 0046-9999-17-044-L04-P, 0046-9999-17-045-L04-P 0046-9999-17-046-L04-P provides 11.00 contact hours of continuing pharmacy education credit.   To receive CE credit, you must complete the CE attendance form and the online evaluation of the program. Statements of credit can be viewed and printed in CPE Monitor in approximately 2 to 3 weeks.