UNC-Duke Collaborative Clinical Pharmacology T32 Postdoctoral Training Program Participants

Izna Ali, Pharm.D.

Mentor: Kim Brouwer, Pharm.D., Ph.D.; Paul Watkins, M.D.

Project Title: Disease-mediated Alterations in Transporter Function and the Impact of Transporters on Drug Safety and Efficacy


Stephen Balevic, M.D.

Mentor: Michael Cohen Wolkowiez, M.D.; Laura E. Schanberg, M.D.
Project title: 
Effect of Serum Hydroxychloroquine Levels on Neonatal Outcomes During Pregnancy


Ryan Beechinor, Pharm.D.

Mentor: Daniel Gonzalez, Pharm.D., Ph.D.; Angela Kashuba,B.Sc.Phm., Pharm.D., DABCP, FCP
Project title: 
Population Pharmacokinetics of Methotrexate in Infants


Nazario Rivera Chapparo, M.D.

Mentor: Michael Cohen-Wolkowiez, M.D.; Philip B. Smith, M.D.
Project title: 
Micafungin Safety Profile in Neonates


Samantha Dallefeld, M.D.

Mentor: Philip B. Smith, M.D.; Kanecia Zimmerman, M.D.
Project title: 
Pharmacokinetics of Dexmedetomidine in Children Supported with ECMO


 

Estefany Garcia, Pharm.D.

Mentor: Gauri Rao, Pharm.D., M.S.; Alan Forrest, Pharm.D.

Project Title: Double and Triple Combination in KPC-Producing Klebsiella Pneumononiae to Overcome Multidrug Resistance


Stephen Greene, Pharm.D.

Mentor: Julie Dumond, Pharm.D.; Kim Brouwer, Pharm.D., Ph.D.
Project title:
Compartmental Pharmacology of Antiretrovirals (ARVs) in the Blood and Semen of HIV-Positive and Negative Men Taking Tenofovir Disoproxil Fumarate or Tenofovir Alafenamide; Hepatic Disposition of Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)


Sara Salerno, Pharm.D.

Mentor: Daniel Gonzalez, Pharm.D., Ph.D.; Michael Cohen-Wolkowiez, M.D., Ph.D.; Kevin Watt, M.D., Ph.D.

Project Title: Pharmacokinetic/Pharmacodynamic Modeling, Simulation, and Drug Metabolism


 

Katherine Westmoreland, M.D.

Mentor: Satish Gopal, M.D., M.P.H.; Daniel Gonzalez, Pharm.D., Ph.D.; Patrick Thompson, M.D.

Project Title: Pharmacokinetics of Methotrexate in Children and Adolescents with Burkitt Lymphoma in Malawi

Allison Burbank, M.D.

Mentors: David Peden, M.D.; Michelle Hernandez, M.D.; Maya Jerath, M.D.
Project title:
 Novel Treatment strategies for asthma which is non responsive to conventional therapies


 

Gwen Bernacki, M.D., M.H.S.A.

Current Position: Postdoctoral Fellow, Duke University

Mentors: Richard Becker, M.D.; Daniel K. Benjamin Jr., M.D., Ph.D., M.P.H.
Project Titles: 1) Oral Anticoagulants in Older Adults with Atrial Fibrillation 2) PLAtelet Response to Age, NuTrition, Fitness Or Mood (PLATFORM) Study 3) Characteristics of Medicare Beneficiaries with Frequent Readmissions after Non-ST-Elevation Myocardial Infarction 4) Essentials of Cardiac Care for Older Adults (ECCOA) Updates


Austin Chan, M.D.

Mentor: Michael Cohen-Wolkowiez, M.D.; Susanna Naggie M.D.; Pamela Douglas, M.D.
Project title: HCV Virologic Outcomes in Patients taking Ledipasvir/Sofosbuvir with Concomitant Acid Suppressing Medication


R_Church

Rachel Church, Ph.D.

Mentor: Paul Watkins, M.D. 
Project title:
 Identification and Characterization of Biomarkers of Drug-Induced Liver Injury


M_Cottrell

MacKenzie Cottrell, Pharm.D.

Mentors: Angela DM Kashuba, Pharm.D.; Julie Dumond, Pharm.D., M.S.; Heyward Hull, Pharm.D., M.S. 
Project title:
 Utilizing Clinical Pharmacology Methods to Optimize Antiretroviral Agents for Pre-Exposure Prophylaxis (PrEP)


D_Crona

Dan Crona, Pharm.D., Ph.D.

Mentors: Federico Innocenti, M.D., Ph.D.; and Howard McLeod, Pharm.D.
Project title:
 Predictive and Prognostic Germline Variations that Associate with Overall Survival in Metastatic Renal Cell Carcinoma Patients Treated with Sorafenib


D_Gonzales

Daniel Gonzalez, Pharm.D., Ph.D.

Current Position: Assistant Professor, UNC Eshelman School of Pharmacy

Mentors: Daniel K. Benjamin Jr., M.D., Ph.D., M.P.H.; Kim L.R. Brouwer, Pharm.D., Ph.D.; Michael Cohen-Wolkowiez, M.D., Ph.D.
Project Titles: Population Pharmacokinetics of Clindamycin in Premature Infants to Adolescents


W_Kirschbrown

Whitney Caron Kirschbrown, Pharm.D., Ph.D.

Current Position: Senior Clinical Pharmacokineticist II, AbbVie, San Francisco, CA

Mentor: William Zamboni, Pharm.D., Ph.D.
Projects: Profiling Factors that Affect the Pharmacokinetics and Pharmacodynamics of Nanoparticles in Preclinical and Clinical Systems


L_Ku

Lawrence Ku, M.D.

Current Position: Clinical Fellow, Duke University Pediatrics

Mentors: Tim Wiltshire, Ph.D.

Project Title: Adverse Events in Extremely Low Birth Weight Infants Exposed to Furosemide or Bumetanide in the Neonatal Intensive Care Unit


R_Mentz

Robert Mentz, M.D.

Current Position: Assistant Professor, Duke University, Cardiology

Mentors: Daniel K. Benjamin Jr., M.D., Ph.D., M.P.H.; Christopher M. O’Connor, M.D.; Michael Felker, M.D., M.H.S.
Project Title: Pharmacologic Interventions in Acute and Chronic Heart Failure Patients with Comorbid Diseases


M_Nicol

Melanie Nicol, Pharm.D., Ph.D.

Current Position: Assistant Professor, University of Minnesota College of Pharmacy

Mentor: Angela Kashuba, BScPhm., Pharm.D., D.A.B.C.P.
Projects: Pre-Exposure Prophylaxis for HIV: Linking Antiretroviral Pharmacokinetics and Pharmacodynamics to Identify Optimal Dosing Strategies


O_Nwankwo

Onyeka Nwankwo, M.D.

Mentors: David Weber, M.D., Ph.D.; Angela DM Kashuba, Pharm.D., DABCP
Project title:
 1) The Development of Gram Negative Antibiotic Resistance in Critically Ill Patients Receiving Extended Duration Therapy; 2) Tigecycline use and Clostridium Difficile infection rates in a burn unit.


A_Oni-Orisan

Akinyemi Oni-Orisan, Pharm.D.

Mentors: Craig Lee, Pharm.D., Ph.D.; and Paul Watkins, M.D.
Project Title: Soluble Epoxide Hydrolase and Cardioprotection: Translation from Mice to Humans


Nikolas_Onufrak_Crop

Nikolas Onufrak, Pharm.D.

Mentor: Daniel Gonzalez, Pharm.D., Ph.D.; Christoph Hornik, M.D., M.P.H.; Alan Forrest, Pharm.D.
Project title: Development of an Open-Source Tool of Individualization of Drug Therapy Regimens in Pediatric Populations


 

Kishan Parikh, M.D.

Mentor: Daniel K. Benjamin Jr., M.D., M.P.H.
Project title: 
Precision medicine and the ability to accurately phenotype and monitor patients with the goal of providing targeted therapy


A_Patil

Avinash Patil, M.D.

Current Position: Assistant Professor, Indiana University School of Medicine, Maternal and Fetal Medicine and Clinical Pharmacology.

Mentors: Geeta Swamy, M.D.; Daniel K. Benjamin Jr., M.D., Ph.D., M.P.H.
Project Title: Fetal Metabolism of Progesterone: Effect of Proposed Metabolites on Uterine Contractility


M_Sampson

Mario Sampson, Pharm.D.

Current Position: Clinical Pharmacology Reviewer, US FDA

Mentors: Kim L.R. Brouwer, Pharm.D., Ph.D.; Daniel K. Benjamin Jr., M.D., Ph.D., M.P.H.
Project Titles: 1) The Effect of Lovastatin on Warfarin Pharmacokinetics and Pharmacodynamics in Healthy Adults: Role of CYP4F2; 2) Population Pharmacokinetics of Azithromycin in Blood, Peripheral Blood Mononuclear Cells, and Polymorphonuclear Cells of Healthy Adults


Corbin Thompson, Pharm.D.

Mentors: Angela Kashuba, Pharm.D.
Project title: 
Characterizing Antiretroviral Distribution Within HIV Tissue Reservoirs


 

Kevin Turner, M.D.

Current Position: Neonatologist, St. Vincent’s Healthcare System, FL

Mentors: Matthew Laughon, M.D., M.P.H., Daniel K. Benjamin Jr., M.D., Ph.D., M.P.H., Kim L.R. Brouwer, Pharm.D., Ph.D.
Projects: Safety and Pharmacokinetics of Single and Multiple Dose Rifampin in Infants


K_Watt

Kevin Watt, M.D.

Mentors: Daniel Benjamin, Jr., M.D., Ph.D., M.P.H.; and Kim Brouwer, Pharm.D., Ph.D.
Project title: Pharmacokinetics and Safety of Fluconazole in Children Supported with Extracorporeal Membrane Oxygenation; Development of Drug Dosing Guidelines for Obese Children


Jennifer Waugh, M.D.

Mentors: Paul Armistead M.D., Ph.D.; Jonathan Serody M.D.; Claire Dees, M.D., M.Sc.
Project title:
 Targeting AML through MerTK Inhibition: The Role of Stromal Interactions and Immune Evasion


N_Zane

Nicole Zane, Pharm.D.

Mentors: Dhiren Thakker, Ph.D.; Daniel K. Benjamin Jr., M.D., Ph.D., M.P.H.; Kim L.R. Brouwer, Pharm.D., Ph.D.
Project title:
 Predicting Pharmacokinetic Behavior and Dose of Sildenafil and Voriconazole In Neonatal and Pediatric Populations by In Vitro Metabolism and Physiologically-Based Pharmacokinetic (PBPK) Modeling


K_Zimmerman

Kanecia Zimmerman, M.D., M.P.H.

Current Position: Clinical Fellow, Duke University Pediatrics

Mentors: Michael Cohen-Wolkowiez, M.D., Ph.D.; Brian Smith, M.D., M.P.H., M.H.S.; Kevin Watt, M.D.
Projects: PK/PD of sedatives and analgesics, drug disposition in ECMO, and the use of drugs in palliative care

kbrouwer_jun15-directory

Kim LR Brouwer, Pharm.D., Ph.D.

Program Co-Director & Mentor

kbrouwer@unc.edu

https://pharmacy.unc.edu/kim-brouwer-lab/

Affiliation: Associate Dean for Research and Graduate Education, Professor, Division of Pharmacotherapy & Experimental Therapeutics, School of Pharmacy (Curriculum in Toxicology, School of Medicine)

Research Interests: Hepatic drug transport (mechanisms, model systems, clinical probes); clinical DDIs and disease state alterations in drug disposition/biliary clearance; drug-induced hepatotoxicity

DDA, QPT, TOX


 

Daniel K Benjamin, M.D., Ph.D., M.P.H.

Program Co-Director & Mentor

https://www.dcri.org/directory/benja005

Affiliation: Professor, Pediatric Infectious Diseases; Associate Director Duke Clinical Research Institute

Research Interests: Neonatal antimicrobial pharmacokinetic and therapeutic drug trials; Antifungal pharmacokinetics/pharmacodynamics

QPT, DDA


pbwatkins_jun15-directory

Paul Watkins, M.D.

Program Co-Director & Mentor

pwatkins@email.unc.edu

Affiliation: Director, UNC Institute for Drug Safety Sciences; Professor, Division of Pharmacotherapy & Experimental Therapeutics, School of Pharmacy & Division of Gastroenterology & Hepatology, School of Medicine

Research Interests: Mechanisms underlying idiosyncratic hepatotoxicity; inter-individual differences in the pharmacokinetics of drugs and other chemicals (xenobiotics);

TOX, QPT, DA


angela-kashuba_2015

Angela DM Kashuba, Pharm.D.

Fellowship co-Director/ Mentor

akashuba@unc.edu

https://pharmacy.unc.edu/research/labs/angela-kashuba-lab

Affiliation: Professor and Chair, Division of Pharmacotherapy & Experimental Therapeutics, School of Pharmacy; Director, Clinical Pharmacology and Analytical Chemistry Core, UNC Center for AIDS Research; Director, Pharmacology Core, UNC Collaboratory of AIDS Researchers for Eradication, Division of Infectious Diseases, School of Medicine

Research Interests: Clinical pharmacology of antiretroviral agents in HIV infection; preventing HIV transmission; understanding/predicting drug-drug interactions and adverse events; sex and ethnicity in drug disposition

DDA, QPT, TOX


Michael Cohen-Wolkowiez, M.D., Ph.D.

Fellowship co-Director/ Mentor

https://www.dcri.org/michael-cohen-wolkoweiz/

Affiliation: Associate Professor, Department of Pediatrics, School of Medicine

Research Interests: Pharmacokinetics and pharmacodynamics of drugs in children, minimal risk methods, phase 1 studies in humans

QPT, DDA, TOX


Robert Noveck, M.D., Ph.D.

Fellowship co-Director/ Mentor

http://medicine.duke.edu/faculty/details/0516151

Affiliation: Associate Professor, Co-Director, Division of Clinical Pharmacology, Department of Medicine, School of Medicine; Medical Director Duke Clinical Research Unit

Research Interests: Phase 1 studies in humans

QPT, DDA


Richard Boucher, M.D.

Mentor

http://www.med.unc.edu/cfpulmcenter/about-us/faculty/boucher

Affiliation: Professor, Division of Pulmonary & Critical Care Medicine, School of Medicine; Director, Cystic Fibrosis & Pulmonary Research and Treatment Center

Research Interests: Normal physiology of airway surface liquids and how this system fails in airways diseases

DDA, QPT, PGX


E. Claire Dees, M.D., M.Sc.

Mentor

https://unclineberger.org/people/e.-claire-dees

Affiliation: Professor, School of Medicine-Division of Hematology & Oncology; Lineberger Comprehensive Cancer Center

Research Interests: Breast Cancer; Phase I trials

DDA, QPT


Joseph Eron, M.D.

Mentor

https://www.med.unc.edu/infdis/about/faculty/joseph-eron-md

Affiliation: Professor, Division of Infectious Diseases, School of Medicine; Director, Clinical Core, UNC Center for AIDS Research

Research Interests: HIV care, antiretroviral therapy including advanced patients, HIV resistance, primary HIV infection

DDA, QPT


Ronald Falk, M.D.

Mentor

http://unckidneycenter.org/about/directory/ronald-falk

Affiliation: Professor, Division of Nephrology & Hypertension and Dept. of Pathology & Laboratory Medicine, School of Medicine; Director, UNC Kidney Center

Research Interests: Mechanisms underlying glomerular vasculitic diseases and nephrotoxicity; Phase 1-3 clinical trials.

DDA, QPT, TOX


Alan Forrest, Pharm.D.

Mentor

https://pharmacy.unc.edu/news/directory/systat10/

Affiliation: Clinical Professor

Research Interests: Pharmacometrics, quantitative approaches to optimize individual patient therapy, pharmacology of anti-infective agents

QPT


Michael Fried, M.D.

Mentor

https://www.med.unc.edu/gi/faculty-physicians/michael-w-fried-m-d

Affiliation: Professor, Division of Gastroenterology and Hepatology, School of Medicine; Director, UNC Liver Center

Research Interests: Division of Gastroenterology and Hepatology, School of Medicine; Director, UNC Liver Center


Satish Gopal, M.D., M.P.H.

Mentor

http://malawicancerconsortium.web.unc.edu/home-page/investigators/satish-gopal-md-mph/

Affiliation: Director, Malawi Cancer Consortium, Assistant Professor of Medicine, School of Medicine (Divisions of Hematology-Oncology and Infectious Diseases)

Research Interests: Cancer in sub-Saharan Africa, HIV-related malignancies,

TOX

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innocenti_125x165

Federico Innocenti, M.D., Ph.D.

Mentor

https://pharmacy.unc.edu/news/directory/innocent

Affiliation: Associate Professor, Division of Pharmacotherapy & Experimental Therapeutics, School of Pharmacy

Research Interests: Genomic determinants of efficacy and toxicity of cancer chemotherapy

PGX, DDA, QPT


 

Matthew Laughon, M.D., M.P.H.

Mentor

Affiliation: Professor of Pediatrics

Research Interests: Epidemiology; clinical trials; and pharmacology

QPT


David Peden, M.D.

Mentor

http://www.med.unc.edu/toxicology/about-us/member-profiles/peden

Affiliation: Professor, Dept. of Pediatrics, School of Medicine; Dept. of Microbiology & Immunology, School of Medicine; Curriculum in Toxicology, School of Medicine; Dept. of Epidemiology, School of Public Health

Research Interests: Translational and clinical research in environmental lung disease, particularly asthma. Novel treatments for asthma.

DDA, QPT


Jonathan Serody, M.D.

Mentor

https://unclineberger.org/people/jonathan-s.-serody

Affiliation: Professor, Division of Hematology & Oncology, School of Medicine; Dept. of Microbiology & Immunology, School of Medicine

Research Interests: Migration of dendritic cells and subpopulations of T lymphocytes during graft-versus-host disease (GVHD) after allogeneic stem cell transplantation and as a consequence of induction of an immune response to tumors using vaccine therapy

DDA


Patrick Thompson, M.D.

Mentor

Affiliation: Associate Professor of Pediatrics

Research Interests: Developmental therapeutics, liver tumors, early phase clinical trials

QPT


zamboni_jun15-directory

William Zamboni, Pharm.D., Ph.D.

Mentor

https://pharmacy.unc.edu/Directory/zamboni

Affiliation: Associate Professor, Division of Pharmacotherapy & Experimental Therapeutics, School of Pharmacy; Lineberger Comprehensive Cancer Center

Research Interests: Application of pharmacokinetic, pharmacodynamic, and pharmacogenetic principles in the optimization of the chemotherapeutic treatment of cancer

QPT, PGX, DDA

 

Vance Fowler, M.D., M.H.S.

Mentor

https://medicine.duke.edu/faculty/vance-garrison-fowler-md

Affiliation: Professor, Division of Infectious Diseases, Department of Medicine; Department of Molecular Genetics and Microbiology, School of Medicine

Research Interests: Pathogenesis of bacterial infections; Infections due to resistant organisms

DDA


Adrian Hernandez, M.D., M.H.S.

Mentor

https://www.dcri.org/adrian-hernandez

Affiliation: Associate Professor, Division of Cardiology; Department of Medicine; School of Medicine

Research Interests: Cardiovascular and metabolic therapeutics, clinical development of treatments for heart failure and diabetes mellitus

DDA


Jennifer Li, M.D., M.H.S..

Mentor

Jennifer Li

Affiliation: Professor & Division Chief, Pediatric Cardiology Director of Pediatric Clinical Research, DCRI Director of Pediatric Research, DTMI

Research Interests: Pediatric cardiovascular diseases and treatment including phase I and multi-center trials

QPT, DDA


Scott Palmer, M.D., M.H.S.

Mentor

http://www.dcri.org/scott-palmer/

Affiliation: Associate Professor, Medicine; Director Pulmonary Research, Duke Clinical Research Institute

Research Interests: Clinical, basic and translational research in transplantation and advanced lung diseases

DDA


P. Brian Smith, M.D., M.H.S., M.P.H.

Mentor

http://scholars.duke.edu/display/per6446862

Affiliation: Associate Professor, Chief, Division of Quantitative Sciences, Department of Pediatrics

Research Interests: Nosocomial infections; neonatal candidiasis; neonatal pharmacology; drug safety

DDA, TOX, QPT


Geeta Swamy, M.D.

Mentor

http://medschool.duke.edu/about-us/our-faculty/geeta-swamy-md

Affiliation: Associate Professor, Divisions of Maternal-Fetal Medicine and Clinical & Epidemiological Research

Research Interests: Clinical trials in pregnant women including vaccine development

QPT

DDA – Drug Disposition & Action;

QPT – Quantitative Pharmacology & Clinical Trial Design;

PGX – Pharmacogenomics;

TOX – Drug-Induced Organ Toxicity

The UNC-Duke Collaborative Clinical Pharmacology Training program, the University of North Carolina at Chapel Hill and Duke University are equal opportunity educational institutions, are committed to the principle of diversity and are particularly interested in receiving applications from a broad spectrum of people, including minorities, protected veterans, and individuals with disabilities.

The UNC-Duke Collaborative Clinical Pharmacology Training Program is committed to providing reasonable accommodations. Individuals with disabilities seeking additional information about services available on the UNC and Duke campuses may visit these sites: