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About Marsico Hall

Marsico Hall opened in the spring of 2014 and houses research laboratories from both the School of Medicine and the UNC Eshelman School of Pharmacy. The Centers’ labs (~10,000 sq ft) and offices are on the third and fourth floors of the nine-story building. Access to parts of the facility is controlled so appointments are recommended.

Marsico Hall was dedicated on March 27, 2014, and is named in honor of Thomas F. Marsico of Denver, Colorado, for his lifetime contributions to health-care programs at UNC.

What We Do

The Center’s research explores small molecule probes, drug leads, and target validation via proposals from UNC faculty and Center-initiated projects in chromatin chemical biology.

Goals Of The Center

• Enable interrogation of biology with small molecules resulting in novel insights into human disease with a focus on oncology
• Create the leading research program in chemical biology of chromatin regulation
• Provide student and faculty training and enrichment in the areas of expertise within the Center
• Create intellectual property to support translational drug discovery
• Establish collaborations and funding base such that the Center is sustainable

News

Stephen Frye receives Maximizing Investigators’ Research Award, tops $2 million, supports small molecule research to identify new approaches to modulating drug targets

Each day, Stephen Frye, Ph.D., works to identify pharmacologic approaches to intervene in novel drug targets within the human body with the goal of creating new therapeutic interventions that will directly aid patients. Today, he’s pushing his work further with … Read more

Wang receives $2.5 million grant to further novel cancer treatment research

Xiaodong Wang, Ph.D., has received a selective $2.5 million R01 grant from the National Institutes of Health to research and develop a new treatment for targeting tumor cells. Wang is a research associate professor at the UNC Eshelman School of … Read more

Pinnacle Hill Announces First Project Agreement

Alliance Between UNC-Chapel Hill and Deerfield intends to advance select Carolina innovations toward a possible new treatment against multiple myeloma Pinnacle Hill, the research and development partnership between the University of North Carolina at Chapel Hill and Deerfield Management Company, … Read more

Researchers develop data-driven strategy to discover cancer therapies

Drug discoverers Dmitri Kireev, Ph.D., and Xiaodong Wang, Ph.D., of the UNC Eshelman School of Pharmacy have created a data-driven strategy to be able to treat diseases such as acute myeloid leukemia and nonsmall cell lung cancer. Kireev said controlling … Read more

New NIH proposal aims to advance Alzheimer’s drug discovery research

(Photo courtesy of Stephen Frye) A group of researchers from the University of North Carolina at Chapel Hill are part of a new research proposal to create chemical and biological tools to explore novel molecular targets related to Alzheimer’s disease. … Read more

Albert Bowers Promoted to Associate Professor

Albert Bowers, Ph.D., a faculty member in the Division of Chemical Biology and Medicinal Chemistry, has been promoted to the rank of associate professor at the UNC Eshelman School of Pharmacy. Bowers is a member of the UNC Lineberger Comprehensive … Read more

Researchers Discover Compound with Potential to Stop Cancer Metastasis

A UNC Eshelman School of Pharmacy scientist is a leader in a large research collaboration that has discovered a new compound that suppressed the spread of cancer — a process known as metastasis — in three different animal models of … Read more

Bowers Receives $1.9 M NIGMS Outstanding Investigator Award

Albert Bowers, Ph.D., has received a R35 Outstanding Investigator Award worth more than $1.9 million over five years from the National Institute of General Medical Sciences to study the chemoenzymatic synthesis, mode of action and evolution of natural product-based macrocycles. … Read more