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Most Recent Publications

  1. Roth MT, Mumper RJ, Singleton SF, Lee CR, Rodgers PT, Cox WC, McLaughlin JE, Joyner P, Blouin RA. A renaissance in pharmacy education at the University of North Carolina at Chapel Hill. N C Med J. 2014 Jan-Feb;75(1):48-52. PubMed PMID: 24487762.

  2. Peterson EJ, Kireev D, Moon AF, Midon M, Janzen WP, Pingoud A, Pedersen LC, Singleton SF. Inhibitors of Streptococcus pneumoniae surface endonuclease EndA discovered by high-throughput screening using a PicoGreen fluorescence assay. J Biomol Screen. 2013 Mar;18(3):247-57. doi: 10.1177/1087057112461153. Epub 2012 Sep 26.PubMed PMID: 23015019.

  3. Evidence for dynamics in proteins as a mechanism for ligand dissociation. Carroll MJ, Mauldin RV, Gromova AV, Singleton SF, Collins EJ, Lee AL. Nat Chem Biol. 2012 Jan 15. doi: 10.1038/nchembio.769. [Epub ahead of print] PMID: 22246400 [PubMed - as supplied by publisher]
  4. High-Throughput Screening for RecA Inhibitors Using a Transcreener Adenosine 5'-O-Diphosphate Assay. Peterson EJ, Janzen WP, Kireev D, Singleton SF. Assay Drug Dev Technol. 2011 Dec 22. [Epub ahead of print] PMID: 22192312 [PubMed - as supplied by publisher]
  5. Direct detection of structurally resolved dynamics in a multiconformation receptor-ligand complex. Carroll MJ, Gromova AV, Miller KR, Tang H, Wang XS, Tripathy A, Singleton SF, Collins EJ, Lee AL. J Am Chem Soc. 2011 Apr 27;133(16):6422-8. Epub 2011 Apr 6. PMID: 21469679 [PubMed - indexed for MEDLINE]
  6. Novel Inhibitors of E. coli RecA ATPase Activity. Sexton JZ, Wigle TJ, He Q, Hughes MA, Smith GR, Singleton SF, Williams AL, Yeh LA. Curr Chem Genomics. 2010 May 26;4:34-42. PMID: 20648224 [PubMed]
  7. Inhibitors of RecA activity discovered by high-throughput screening: cell-permeable small molecules attenuate the SOS response in Escherichia coli. Wigle TJ, Sexton JZ, Gromova AV, Hadimani MB, Hughes MA, Smith GR, Yeh LA, Singleton SF. J Biomol Screen. 2009 Oct;14(9):1092-101. Epub 2009 Aug 12. PMID: 19675313 [PubMed - indexed for MEDLINE] Free PMC Article
  8. A complementary pair of rapid molecular screening assays for RecA activities. Lee AM, Wigle TJ, Singleton SF. Anal Biochem. 2007 Aug 15;367(2):247-58. Epub 2007 Apr 20.
    PMID: 17601483 [PubMed - indexed for MEDLINE]
  9. Directed molecular screening for RecA ATPase inhibitors. Wigle TJ, Singleton SF. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3249-53. Epub 2007 Apr 10. PMID: 17499507 [PubMed - indexed for MEDLINE]
  10. Inhibition of Escherichia coli RecA by rationally redesigned N-terminal helix. Cline DJ, Holt SL, Singleton SF. Org Biomol Chem. 2007 May 21;5(10):1525-8. Epub 2007 Apr 18.
    PMID: 17571180 [PubMed - indexed for MEDLINE]
  11. Probing the structure of RecA-DNA filaments. Advantages of a fluorescent guanine analog.
    Singleton SF, Roca AI, Lee AM, Xiao J. Tetrahedron. 2007 Apr 23;63(17):3553-3566. PMID: 17955055 [PubMed]
  12. Direct evaluation of a kinetic model for RecA-mediated DNA-strand exchange: the importance of nucleic acid dynamics and entropy during homologous genetic recombination.
    Xiao J, Lee AM, Singleton SF. Chembiochem. 2006 Aug;7(8):1265-78. PMID: 16847846 [PubMed - indexed for MEDLINE]

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