Examples of Recent Publications & Patents: selected from more than 740 articles and 77 patents

1. K.H. Lee, "Antitumor Agents 231 and Anti-AIDS Agents 59. Current Developments in the Discovery and Design of New Drug Candidates from Plant Natural Product Leads," J. Nat. Prod., 67, 272-283 (2004) and literature cited therein.
2. L. Wei, A. Brossi, R. Kendall, K.F. Bastow, S.L. Morris-Natschke, Q. Shi and K.H. Lee, “Antitumor Agents 251: Synthesis, Cytotoxic Evaluation, and Structure-Activity Relationship Studies of Phenanthrene-based Tylophorine Derivatives (PBTs) as a New Class of Antitumor Agents,” Bioorg. Med. Chem., 14, 6560-6569 (2006).  Most Cited Paper 2006-2009 Award from BMC
3. K. Qian, R.Y. Kuo, C.H. Chen, L. Huang, S.L. Morris-Natschke, and K. H. Lee, “Anti-AIDS Agents 81. Design, Synthesis and Structure-Activity Relationship Study of Betulinic Acid and Moronic Acid Derivatives as Potent HIV Maturation Inhibitors,” J. Med. Chem., 53, 3133-3141 (2010).
4. X. Yang, Q. Shi, S.C. Yang, C.Y. Chen, S.L. Yu, K.F. Bastow, S.L. Morris-Natschke, P.C. Wu, C.Y. Lai, T.S. Wu, S.L. Pan, C.M. Teng, J.C. Lin, P.C. Yang, and K.H. Lee, “Antitumor agents 288: Design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents,” J. Med. Chem., 54, 5097-5107 (2011).
5. K.H. Lee, X.H. Wang, K.F. Bastow, and T.S. Wu, "Neo-tanshinlactone and Analogs as Potent and Selective Anti-breast Cancer Agents," US Patent No. 20050250751: Issued 11/10/2005.

Selected Papers from the Past Five Years

1. M. Shibano, A. Lin, H. Itokawa, and K.H. Lee, “Separation and Characterization of Active Favonolignans of Silybum marianum by Liquid Chromatography Connected with Hybrid Ion-trap and Time-of-flight Mass Spectrometry (LC-MS/ IT-TOF),” J. Nat. Prod., 70, 1424-1428 (2007).
2. D. Yu, S.L. Morris-Natschke, and K.H. Lee, “Anti-AIDS Agent 67. New Developments in Natural Products-based Anti-AIDS Research,” Med. Res. Rev., 27, 108-132 (2007).
3. X. Wang, S.L. Morris-Natschke and K. H. Lee, “Antitumor Agents 245. New Developments in the Chemistry and Biology of the Bioactive Constituents of Tanshen,” Med. Res. Rev., 27, 133-148 (2007).
4. S. Zhang, L. Wei, K. Bastow, W. Zheng, A. Brossi, K. H. Lee, and A. Tropsha, “Antitumor Agents 252. Application of Validated QSAR Models to Database Mining: Discovery of Novel Tylophorine Derivatives as Potential Anticancer Agents,” J. Computer-Aided Molecular Design, 21, 97-112 (2007).
5. L. Wei, Q. Shi, K.F. Bastow, A. Brossi, S.L. Morris-Natschke, K. Nakagawa-Goto, T.S. Wu, S.L. Pan, C.M. Teng, and K. H. Lee, “Antitumor Agents 253. Design, Synthesis and Antitumor Evaluation of Novel 9-Substituted Phenanthrene-based Tylophorine Derivatives as Potential Anticancer Agents,” J. Med. Chem., 50, 3674-3680 (2007).
6. K. Nakagawa-Goto, T.H. Chen, C.Y. Peng, K.F. Bastow, J.H. Wu, and K.H. Lee, “Antitumor Agents 259. Designs, Sytheses and Structure-Activity Relationship Study of Desmosdumotin C Analogs,” J. Med. Chem., 50, 3354-3358 (2007).
7. A.S. Lin, K. Nakagawa-Goto, F.R. Chang, D. Yu, S.L. Morris-Natschke, C.C. Wu, S.L. Chen, Y.C. Wu and K.H. Lee, “First Total Synthesis of Protoapigenone and its Analogs as Potent Cytotoxic Agents,” J. Med. Chem., 50, 3921-3927 (2007).
8. L. Wei, A. Brossi, S.L. Morris-Natschke, K.F. Bastow, and K. H. Lee, “Antitumor Agents 248. Chemistry and Antitumor Activity of Tylophorine-related Alkaloids,” Studies in Natural Product Chemistry (Bioactive Natural Products), Ed. Atta-ur-Rahman, Elsevier, New York, Vol. 34, pp. 3-34 (2008).
9. L. Xie, H.Guo, H. Lu, X.Zhuang, A.Zhang, G.Wu, J.Ruan, T.Zhou, D.Yu, K.Qian, K.H.Lee and S.Jiang, “Development and Preclinical Studies of Broad-spectrum Anti-HIV Agent (3′R,4′R)-3-Cyanomethyl-4-methyl-3′,4′-di-O-(S)-camphanoyl -(+)-cis-khellactone (3-Cyanomethyl-4-methyl-DCK),” J. Med. Chem., 51, 7689-7696 (2008).
10. K. Nakagawa-Goto, K.F. Bastow, T.H. Chen, S.L. Morris-Natschke and K.H. Lee, “Antitumor Agents 260. New Desmosdumotin B Analogs with improved in Vitro Anticancer Activity,” J. Med. Chem., 51, 3297-3303 (2008).
11. Y. Usami, Y.N. Liu, A.S. Lin, M. Shibano, T. Akiyama, H. Itokawa, S. Morris-Natschke, K. Bastow, R. Kasai and K.H. Lee, “Antitumor Agents 261. 20(S)-Protopanaxadiol and 20(S)-Protopanaxatriol as Anti-angiogenic Agents and Total Assignment of ¹H – NMR Spectra,” J. Nat. Prod., 71, 478-481 (2008).
12. J.C. Lin, S.C. Yang, T.M. Hong, S.L. Yu, Q. Shi, L. Wei, H.Y. Chen, P.C. Yang and K.H. Lee, “Phenanthrene-Based Tylophorine-1 (PBT-1) Inhibits Lung Cancer Cell Growth through the Akt and NF-κB Pathways,” J. Med. Chem., 52, 1903-1911 (2009).
13. K. Qian, S.L. Morris-Natschke, and K.H. Lee, “Anti-AIDS Agents 75. HIV Entry Inhibitors and Their Potential in HIV Therapy,” Med. Res. Rev., 29, 369-393 (2009).
14. K. Qian, T.J. Nitz, D. Yu, G.P. Allaway, S.L. Morris-Natschke, and K.H. Lee, “Anti-AIDS Agents 76. From Natural Product to Clinical Trial – Bevirimat, a Natural Product Derived Anti-AIDS Drug,” In T. Buss and M. Butler, Eds., Natural Product Chemistry for Drug Discovery, for the Royal Society of Chemistry Biomolecular Sciences Series, Chapter 13, pp. 374-391, Merlion Pharmaceuticals Pte Ltd Press, Singapore, 2009.
15. K. Qian, D. Yu, C.H. Chen, L. Huang, S.L. Morris-Natschke, T.J. Nitz, K. Salzwdedl, M. Reddick, G.P. Allaway, and K.H. Lee, “Anti-AIDS Agents 78. Design, Synthesis, Metabolic Stability Assessment, and Anti-HIV Evaluation of Novel Betulinic Acid Derivatives as Potent Anti-HIV-1 Agents,” J. Med. Chem., 52, 3248-3258 (2009).
16. Y.H. Chang, M.H. Hsu, S.H. Wang, L.J. Huang, K. Qian, S.L. Morris-Natschke, E. Hamel, S.C. Kuo, and K.H. Lee, “Design and Synthesis of 2-(3-Benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one Analogs as Potent Antitumor Agents that Inhibit Tubulin Assembly,” J. Med. Chem., 52, 4883-4891 (2009).
17. K.H. Lee, H. Itokawa, T. Akiyama and S.L. Morris-Natschke, “Antitumor Agents 257 and Anti-AIDS Agents 71. Plant-Derived Natural Products Research: Recent Progress in Drug Discovery” Volume 3, pp 690-712, in Wiley Encyclopedia of Chemical Biology, John Wiley & Sons, Hoboken, 2009.
18. Q. Shi, C.Y. Shih, and K.H. Lee, “Antitumor Agents 265. Novel Anti-Prostate Cancer Curcumin Analogs that Enhance Androgen Receptor Degradation Activity,” Anticancer Agents Med. Chem., 9, 904-912 (2009).
19. Y. Dong, Q. Shi, Y.N. Liu, X. Wang, K.F. Bastow and K.H. Lee, “Antitumor Agents 266. Design, Synthesis and Biological Evaluation of Novel 2-(Furan-2-yl) naphthalene-1-ol derivatives as Potent and Selective Anti-Breast Cancer Agents,” J. Med. Chem., 52, 3586-3590 (2009).
20. R.Y. Kuo, K. Qian, S.L. Morris-Natschke and K.H. Lee, “Antitumor Agents 267 and Anti-AIDS Agents 77. Plant-Derived Triterpenoids and Analogues as Antitumor and Anti-HIV Agents,” Nat. Prod. Rep., 26, 1321-1344 (2009).
21. X. Yang, Q. Shi, Y.N. Liu, K.F. Bastow, J.C. Lin, P.C. Yang and K.H. Lee, “Antitumor Agents 268. Design, Synthesis and Mechanistic Studies of New 9-Substituted Phenanthrene-Based Tylophorine Analogs as Potent Cytotoxic Agents,” J. Med. Chem., 52, 5262-5268 (2009).
22. Z. Dang, W. Lai, K. Qian, P. Ho, K.H. Lee, C.H. Chen, and L. Huang, “Betulinic acid derivatives as Human Immunodeficiency Virus Type 2 (HIV-2) inhibitors,” J. Med. Chem., 52, 7887-7891 (2009).
23. K.H. Lee and S.L. Morris-Natschke, “Pharmacognosy in Action. U.S. Academia. University of North Carolina, Chapel Hill,” In G.M. Cragg, J.A. Beutler, and W.P. Jones, EDS., The American Society of Pharmacognosy. 50 years of Progress in Natural Products Research. 1959-2009, Chapter 4, PP 129-131, Omni Press, Madison, WI, 2009.
24. K.H. Lee, “Chapter 9, Major Milestones. Podophyllotoxin and Derivatives,” In G.M. Cragg, J.A. Beutler, and W.P. Jones, EDS., The American Society of Pharmacognosy. 50 years of Progress in Natural Products Research. 1959-2009, Chapter 9, PP 238-240, Omni Press, Madison, WI, 2009.
25. S.J. Wu, Y.L. Leu, C.H. Chen, C.H. Chao, D.Y. Shen, H.H. Chan, E.J. Lee, T.S. Wu, Y.H. Wang, Y.C. Shen, K. Qian, K.F. Bastow, and K.H. Lee, “Camphoratins A-J, Potent Cytotoxic and Anti-inflammatory Triterpenoids from the Fruiting Body of Taiwanofungus camphoratus,” J. Nat. Prod., 73, 1756-1762 (2010).
26. A.C. Tsai, S.L. Pan, H.L. Sun, C.Y. Wang, C.Y. Peng, S.W. Wang, Y.L. Chang, S.C. Kuo, K.H. Lee and C.M. Teng, “CHM-1, a New Vascular Targeting Agent, Induces Apoptosis of Human Umbilical Vein Endothelial Cells Via P53-Mediated Death Receptor 5 Upregulation,” J. Biol. Chem., 285, 5497-5506 (2010).
27. Y. Dong, Q. Shi, H.C. Pai, C.Y. Peng, S.L. Pan, C.M. Teng, K. Nakagawa-Goto, D. Yu, Y.N. Liu, P.C. Wu, K.F. Bastow, S.L. Morris-Natschke, A. Brossi, J.Y. Lang, J. L. Hsu, M.C. Hung, E.Y.-H.P. Lee, and K.H. Lee, “Antitumor Agents 272. Structure–Activity Relationships and In Vivo Selective Anti-Breast Cancer Activity of Novel Neo-tanshinlactone Analogs,” J. Med. Chem., 53, 2299-2308 (2010).
28. X. Yang, Q. Shi, K.F. Bastow, and K.H. Lee, “Antitumor Agents 274. A New Synthetic Strategy for E-Ring SAR study of Antofine and Cryptopleurine Analogues,” Organic. Lett., 12, 1416-1419 (2010).
29. K. Nakagawa-Goto, P.C. Chang, C.Y. Lai, , H.Y. Hung, T.H. Chen, P.C. Wu, H. Zhu, A. Sedykh, K.F. Bastow, and K.H. Lee, “Antitumor Agents 280. Multidrug Resistance-Selective Desmosdumotin B Analogous,” J. Med. Chem., 53, 6699-6705 (2010).
30. Y. Usami, K. Nakagawa-Goto, J.Y. Lang, Y. Kim, C.Y. Lai, M. Goto, N. Sakurai, M. Taniguchi, T. Akiyama, S. Morris-Natschke, K.F. Bastow, G. Cragg, D.J. Newman, M. Fujitake, K. Takeya, M.C. Hung, E.Y.H.P. Lee, and K.H. Lee, “Antitumor Agents 282.  2’-(R)-O-Acetylglaucarubinone, A Quassinoid from Odyendyea gabonensis as a Potential Anti-breast and Anti-ovarian Cancer Agent,” J. Nat. Prod., 73, 1553-1558 (2010).
31. T. Zhou, Q. Shi, K.F. Bastow, and K.H. Lee, “Antitumor Agents 286. Design, Synthesis and Structure-Activity Relationship of 3’R,4’R-Disubstituted-2’,2’-Dimethyldihydropyrano[2,3-f] Chromone (DSP) Analogs as Potent Chemosensitizers to Overcome Multidrug Resistance,” J. Med. Chem. 53, 8700-8708 (2010).
32. L.C. Chou, C.T. Chen, J.C. Lee, T.D. Way, C.H. Huang, S.M. Huang, C.M. Teng, T. Yamori, T.S. Wu, C.M. Sun, D.S. Chien, K. Qian, S.L. Morris-Natschke, K.H. Lee,  L.J. Huang, and S.C. Kuo, “Synthesis and Preclinical Evaluations of 2-(2-Fluorophenyl)-6,7-methylenedioxyquinolin-4-one Monosodium Phosphate (CHM-1P-Na) as a Potent Antitumor Agent,” J. Med. Chem.,  53, 1616-1626 (2010).
33. B. Qin, X. Jiang, H. Lu, X. Tian, F. Barbault, L. Huang, K. Qian, C. Chen, R. Huang, S. Jiang, K.H. Lee, and L. Xie, “Diarylaniline Derivatives as a Distinct Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors,” J. Med. Chem., 53, 4906-4916 (2010).
34. L.C. Chou, M.T. Tsai, M.H. Hsu, S.H. Wang, T.D. Way, C.H. Huang, H.Y. Lin, K. Qian, Y.Z. Dong, K.H. Lee, L.J. Huang and S.C. Kuo, “Design, Synthesis, and Preclinical Evaluation of New 5,6-(or 6,7-)Disubstituted-2-(fluorophenyl)quinolin-4-one Derivatives as Potent Antitumor Agents,” J. Med. Chem., 53, 8047-8058 (2010).
35. X.T. Tian, B.J. Qin, Z.Y. Wu, X.F. Wang, H. Lu, S.L. Morris-Natschke, C.H. Chen, S.B. Jiang, K.H. Lee, and L. Xie, “Design, Synthesis, and Evaluation of Diarylpyridines and Diarylanilines as Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors,” J. Med. Chem., 53, 8287-8297 (2010).
36. K. Nakagawa-Goto, P.C. Wu, C.Y. Lai, E. Hamel, H. Zhu, L. Zhang, T. Kozaka, E. Ohkoshi,  M. Goto, K.F. Bastow, and K.H. Lee “Antitumor Agents 284. New Desmosdumotin-B Analogues with Bicyclic B-ring as Cytotoxic and Antitubulin Agents,” J. Med. Chem., 54, 1244-1255 (2011).
37. Y. Dong, S.L. Morris-Natschke, and K.H. Lee, “Antitumor Agents 285. Biosynthesis, Total Syntheses, and Antitumor Activity of Tanshinones and Their Analogs as Potential Therapeutic Agents,” Nat. Prod. Reports, 28, 529-542 (2011).
38. T.C. Kuo, P.C. Chiang, C.C. Yu, K. Nakagawa-Goto, K.F. Bastow, K.H. Lee and J.H. Guh, “A Unique P-glycoprotein Interacting Agent Displays Anticancer Activity Against Hepatocellular Carcinoma Through Inhibition of GRP78 and mTOR Pathways,” Biochem Pharmacol., 81, 1136-1144 (2011).
39. Y. Asada, A. Sukemori, T. Watanabe, K.J. Malla, T. Yoshikawa, W. Li, K. Koike, C.H. Chen, T. Akiyama, K. Qian, K. Nakagawa-Goto, S.L. Morris-Natschke, K.H. Lee, “Stelleralides A-C, Novel Potent Anti-HIV Daphnane-Type Diterpenoids from Stellera chamaejasme L.,” Org. Lett., 13, 2904-2907 (2011).
40. Q. Wang, W. Hu, S. Wang, Z. Pan, L. Tao, X. Guo, K. Qian, C. Chen, K.H. Lee and J. Chang, “Synthesis of New 2’-Deoxy-2’-fluoro-4’-azido Nucleoside Analogues as Potent Anti-HIV Agents,” Eur. J. Med. Chem., 46, 4178-4183 (2011).