Fontana RJ, Lown KS, Paine MF, Fortlage L, Santella RM, Felton JS, Knize MG, Greenberg A, Watkins PB.  Effects of a chargrilled meat diet on expression of CYP3A, CYP1A, and P-glycoprotein levels in healthy volunteers.  Gastroenterol 117:89-98, 1999.

Malhotra S, Bailey DG, Paine MF, Watkins PB.  Seville orange juice-felodipine interaction: comparison of dilute grapefruit juice and involvement of furocoumarins.  Clin Pharmacol Ther 69:14-23, 2001.

Paine MF, Leung LY, Lim HK, Liao K, Oganesian A, Zhang M-Y, Thummel KE, Watkins PB.  Identification of a novel route of extraction of sirolimus in human small intestine: roles of metabolism and secretion.  J Pharmacol Exp Ther 301:174-186, 2002.

Paine MF, Wagner DA, Hoffmaster KA, Watkins PB.  Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin.  Clin Pharmacol Ther 72:524-35, 2002.

Kakar SM, Paine MF, Stewart PW, Watkins PB.  6',7'-Dihydroxybergamottin contributes to the grapefruit juice effect.  Clin Pharmacol Ther 75:569-79, 2004.

Paine MF, Criss AB, Watkins PB.  Two major grapefruit juice components differ in intestinal CYP3A4 kinetic and binding properties. Drug Metab Dispos 32:1146-53, 2004.

Paine MF, Criss AB, Watkins PB.  Two major grapefruit juice components differ in time to onset of intestinal CYP3A4 inhibition. J Pharmacol Exp Ther 312:1151-60, 2005.

Paine MF, Ludington SS, Chen M-L, Stewart PW, Huang S-M, Watkins PB.  Do men and women differ in proximal small intestinal CYP3A or P-glycoprotein expression?   Drug Metab Dispos 33:426-33, 2005.

Paine MF, Widmer WW, Hart HL, Pusek SN, Beavers KL, Criss AB, Brown SS, Thomas BF, Watkins PB.  A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction.  Am J Clin Nutr 83:1097-105, 2006.

Paine MF, Hart HL, Ludington SS, Haining RL, Rettie AE, Zeldin DC.  The human intestinal cytochrome P450 “pie”.  Drug Metab Dispos 34:880-6, 2006.

Wang MZ, Saulter JY, Usuki E, Cheung YL, Hall M, Bridges AS, Loewen G, Parkinson OT, Stephens CE, Allen JL, Zeldin DC, Boykin DW, Tidwell RR, Parkinson A, Paine MF, Hall JE. CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289. Drug Metab Dispos, 34:1985-94, 2006.

Paine MF, Oberlies NH.  Clinical relevance of the intestine as an organ of drug elimination: drug-fruit juice interactions.  Expert Opin Drug Metab Toxicol 3:67-80, 2007.

Wang MZ, Wu JQ, Bridges AS, Zeldin DC, Kornbluth S, Tidwell RR, Hall JE, Paine MF.  Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine.  Drug Metab Dispos 35:2067-75, 2007.

Paine MF, Widmer WW, Pusek SN, Beavers KL, Criss AB, Snyder J, Watkins PB.  Further characterization of a furanocoumarin-free grapefruit juice on drug disposition: studies with cyclosporine.  Am J Clin Nutr, 87:863-71, 2008.

Wang MZ, Wu JQ, Dennison KB, Bridges AS, Hall SD, Kornbluth S, Tidwell RR, Smith PC, Voyksner RD, Paine MF, Hall JE.  A gel-free MS-based quantitative proteomic approach accurately measures cytochrome P450 protein concentrations in human liver microsomes. Proteomics 8:4186-96, 2008.

Ngo N, Yan Z, Graf TN, Carrizosa DR, Kashuba AD, Dees EC, Oberlies NH, Paine MF.  Identification of a cranberry juice product that inhibits enteric CYP3A-mediated first-pass metabolism in humans.  Drug Metab Dispos 37:514-22, 2009.

Brantley SJ, Oberlies NH, Kroll DJ, Paine MF. Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations. J Pharmacol Exp Ther 332:1081-7, 2010.

Ngo N, Brantley SJ, Carrizosa DR, Kashuba AD, Dees EC, Kroll DJ, Oberlies NH, Paine MF.  The warfarin-cranberry juice interaction revisited: a systematic in vitro-in vivo evaluation involving multiple cranberry juice products.  J Exp Pharmacol 283-91, 2010.

Paine MF, Wang MZ, Generaux CN, Boykin DW, Wilson WD, De Koning HP, Olson CA, Pohlig G, Burri C, Brun R, Murilla GA, Thuita JK, Barrett MP, Tidwell RR. Diamidines for human African trypanosomiasis. Curr Opin Investig Drugs 11:876-83, 2010.

Kim E, Sy-Cordero A, Graf TN, Brantley SJ, Paine MF, Oberlies NH. Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes. Planta Med, in press.