Peer Reviewed Research Articles

26.  Kim AJ, Boylan NJ, Suk JS, Lai SK, Hanes J. (2011) Non-degradative Intracellular Trafficking of Highly Compacted Polymeric DNA Nanoparticles. J Control Release. Accepted.  [Impact 7.16]

25.   Boylan NJ, Suk JS, Lai SK, Jelinek R, Boyle MP, Cooper MJ, Hanes J. (2011) Highly compacted DNA nanoparticles with low MW PEG coatings: In vitro, ex vivo and in vivo evaluation. J Control Release. Accepted.  [Impact 7.16]

24.   Mert O*, Lai SK*, Ensign L, Yang M, Wang YY, Wood J, Hanes J. (2011) A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles.  J Control Release. Accepted. [Impact 7.16]

23.   Suk JS, Boylan NJ, Trehan K, Tang BC, Schneider CS, Lin JM, Boyle MP, Zeitlin PL, Lai SK, Cooper MJ, Hanes J. (2011) N-acetylcysteine Enhances Cystic Fibrosis Sputum Penetration and Airway Gene Transfer by Highly Compacted DNA Nanoparticles. Molecular Therapy. Accepted. [Impact 7.15]

22.   Jachak A, Lai SK, Suk JS, Biswal S, Breysse P, Hanes J. (2011) Transport of Metal Oxide Nanoparticles and Single-walled Carbon Nanotubes across Human Mucus and Effects on Human Bronchial Epithelial Cells. Nanotoxicology. Accepted. [Impact 3.88]

21.   Wang YY, Lai SK, So C, Schneider C, Cone R, Hanes J. (2011) Synthetic nanoparticles may disrupt the protective human mucus barrier by altering the mucus microstructure. PLoS ONE. 6(6): e21547. [Impact 4.41]

20.   Lai SK, Suk JS, Pace A, Wang YY, Yang M, Mert O, Chen J, Kim J, Hanes J. (2011) Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus. Biomaterials. 32(26): 6285-6290. [Impact 7.88]

19.   Hida K, Lai SK, Suk JS, Won SY, Boyle MP, Hanes J. (2011) Common gene therapy viral vectors do not efficiently penetrate sputum from cystic fibrosis patients. PLoS ONE. 6(5):e19919. [Impact 4.41]

18.   Yang M*,Lai SK*, Wang YY, Zhong W, Happe C, Zhang M, Fu J, Hanes J. (2011) Biodegradable Nanoparticles Composed Entirely of Safe Materials that Rapidly Penetrate Human Mucus. Angew Chem Int Ed Engl. 50(11):2597-600. [Impact 12.73] {Cited 5}

Listed by Wiley-VCH in “Hot Topics:  Drug Delivery”; “Polymer coat helps nanoparticles penetrate mucus”, Royal Society of Chemistry.

17.   Suk JS, Lai SK, Boylan NJ, Dawson MR, Boyle MP, Hanes J. (2011) Rapid Transport of Muco-inert Nanoparticles in Cystic Fibrosis Sputum Treated with N-acetyl Cysteine.  Nanomedicine (Lond). 6(2):365-75 [Impact 6.20] {Cited 2}

16.     Lai SK, Wang YY, Hida K, Cone R, Hanes J. (2009) Nanoparticles reveal that mucus is riddled with pores larger than viruses. Proc Natl Acad Sci U S A. 107(2):598-603 [Impact 9.38] Selected for Faculty of 1000 Biology.

15.     Tang BT, Dawson M, Lai SK, Wang YY, Suk JS, Yang M, Zeitlin PL, Boyle MP, Fu J, Hanes J. (2009) Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier. Proc Natl Acad Sci U S A. 106(46):19268-73. [Impact 9.38] In this issue, “Mucus is no match for coated nanoparticles”, PNAS. Selected for Faculty of 1000 Biology.

14.     Lai SK*, Hida K*, Shukair S, Wang YY, Cone R, Hope TJ, Hanes J. (2009) HIV is trapped by acidic but not by neutralized human cervicovaginal mucus. J Virology. 83:11196-11200. [Impact 5.33]

13.     Suk JS*, Lai SK*, Wang YY, Boyle MP, Hanes J (2009). The Penetration of Fresh Undiluted Sputum Expectorated by Cystic Fibrosis Patients by Non-adhesive Polymer Nanoparticles. Biomaterials. 30(13):2591-2597. [Impact 6.65]

12.     Lai SK*, Wang YY*, Cone R, Wirtz D, Hanes J (2009). Selectively Altering Mucus Rheology to "Solidify" Human Mucus at the Nanoscale. PLoS ONE. 4(1): e4294. {Cited 3} “A Better Mesh: Researchers 'Tighten' Body's Protective Coating”, Science Daily; featured in over 10 other science/medical news outlets.

11.     Wang YY*, Lai SK*, Suk JS, Pace A, Cone R, Hanes J. (2008) Addressing the PEG Muco-adhesivity Paradox to Engineer Nanoparticles that “Slip” through the Human Mucus Barrier. Angew Chem Int Ed Engl. 47(50):9726-9729. [Impact 10.88] {Cited 6} News & Views: “Drug delivery: Stealth particles give mucus the slip”, Nature Materials (2009) 8: 11 - 13; News Blog: “Breaking the mucus barrier”, The Scientist (2008); also featured in over 20 other science/medical news outlets.

10.     Lai SK‡, Wang YY, Hanes J‡. (2008) Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Adv Drug Deliv Rev. 61(2):158-171. [Impact 8.29] {Cited 4} Featured on the Cover

9.     Lai SK, Wang YY, Wirtz D, Hanes J. (2008) Micro- and macro-rheology of mucus. Adv Drug Deliv Rev. 61(2):86-100. [Impact 8.29] {Cited 5}

8.     Lai SK, Hida K, Chen C, Hanes J. (2008) Characterization of the intracellular dynamics of a non-degradative pathway accessed by polymer nanoparticles. J Control Release. 125(2):107-111. [Impact 5.69] {Cited 9}

7.     Lai SK, Hida K, Man ST, Chen C, Machamer C, Schroer TA, Hanes J. (2007) Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway. Biomaterials. 28(18): 2876-2884. [Impact 6.65] {Cited 19} Editor’s choice, Drug Discovery Today (2007)

6.     Lai SK, O’Hanlon ED, Harrold S, Man ST, Wang YY, Cone R, Hanes J. (2007) Rapid transport of large polymeric nanoparticles in undiluted human cervical vaginal mucus. Proc Natl Acad Sci U S A. 104(5):1482-1487. [Impact 9.38] {Cited 40} Research highlights include: “Nanoparticles: Against the flow”, Nature Nanotechnology (2007); “Nanoparticles and mucus”, Journal of American Medical Association (2007) 297(9):941; “Coated Nanoparticles Solve Sticky Drug-Delivery Problem”, National Cancer Institute, Alliance for Nanotechnology in Cancer Newsletter.

5.     Suk JS, Suh J, Lai SK, Hanes J. (2007) Quantitative comparison of the real-time transport of viral and nonviral gene vectors in primary neurons. Exp Biol Med (Maywood). 232(3): 461-9. [Impact 2.85] {Cited 13} Society of Experimental Biology & Medicine Best Paper Award for 2007, Basic Biology Section

4.     Castellanos M, Kushiro K, Lai SK, Shuler ML. (2007) A genomically/chemically complete module for synthesis of lipid membrane in a minimal cell. Biotechnol Bioeng. 97(2):397-409. [Impact 3.04] {Cited 2}

3.     Suh J, Choy KL, Lai SK, Suk JS, Tang B, Prabhu S, Hanes J. (2007) PEGylation of nanoparticles improves their cytoplasmic transport. Int J Nanomedicine. 2(4):1-7 {Cited 6}

2.     Suk JS, Suh J, Choy K, Lai SK, Fu J, and Hanes J. (2006) Gene delivery to neurotypic cells with RGD and HIV-1 Tat peptide functionalized polymeric gene vectors. Biomaterials. 27(29):5143-5150. [Impact 6.65] {Cited 30} Listed in 2006 by Science Direct as a “Top 25 Hottest Article” in the area of Biomaterials (based on times downloaded).

1.     Lai SK, Batra A, Cohen C. (2005) Characterization of polydimethylsiloxane elastomer degradation via cross-linker hydrolysis. Polymer. 46: 4204-4211. [Impact 3.33] {Cited 3}

Book Chapters

2.     Kim MS, Lai SK. (2011) Mucosal Barriers to Drug- and Gene-loaded Nanoparticles. In Mass Transport and Biological Barriers to Nanotherapuetics (Chapter 8). R Serda (Ed.) Pan Stanford Publishing, Singapore.

1.     Lai SK, Hanes J. (2007) Real time multiple particle tracking of gene nanocarriers in complex biological environments. In Gene Therapy Protocol, J Ledoux (Ed.), 3rd Ed. The Humana Press, Totowa. (Methods Mol Biol. 2008;434:81-97.)