Welcome to the UNC School of Pharmacy Clinical Pharmacology and Analytical Chemistry Laboratory web site! Our faculty and staff facilitate research in preclinical and clinical pharmacology and analytical chemistry in pursuit of a common goal: optimizing the prevention and treatment of HIV infection. We invite you to learn more about our vigorous research agenda. You are welcome to contact us for further information on our activities and services. I also encourage you to visit the UNC Center for AIDS Research Web site and our Clinical Pharmacology and Analytical Chemistry Core Web site.

What's New

Kashuba Lab Well Represented at the 18th Conference on Retroviruses and Opportunistic Infections

Members of our group presented five abstracts at this year’s CROI focused on the clinical pharmacology of antiretrovirals as related to HIV prevention, aging, and pregnancy. This is a large body of work that represents a tremendous amount of time and effort. Please click on the following links to see the oral presentations and access the posters.

ARV for HIV Prevention: DRV + Low-dose RTV and ETR Exposure in the Rectal Tissue and Seminal Plasma of Healthy Male Volunteers after Single and Multiple Dosing

Kevin Brown*, K Patterson, S Jennings, N Shaheen, H Prince, M Spacek, M Cohen, and A Kashuba

Pharmacokinetics of TDF in Blood Plasma and Cervicovaginal Fluid of HIV+ Post-menopausal Compared with Pre-menopausal Women

Kristine Patterson*, J Dumond, H Prince, E Kraft, J Eron, and A Kashuba

Pharmacokinetics of the LPV/r Tablet in HIV-infected Pregnant Women: A Longitudinal Investigation of Protein Bound and Unbound Drug Exposure with Empiric Dosage Adjustment

Kristine Patterson*¹, J Dumond¹, H Prince¹, A Jenkins¹, K Scarsi², R Wang¹, S Malone¹, M Hughes¹, and A Kashuba¹

RMP-02/MTN-006: A Phase 1 Placebo-controlled Trial of Rectally Applied 1% Vaginal TFV Gel with Comparison to Oral TDF

Peter Anton*¹, R Cranston², A Carballo-Dieguez³, A Kashuba⁴, E Khanukhova¹, J Elliott¹, L Janocko^5,6, W Cumberland⁷, C Mauck⁸, and I McGowan^5,6

Pharmacokinetic and Pharmacodynamic Activity of the Combined Oral Contraceptives in HIV⁺ Women in Lilongwe, Malawi

Gretchen Stuart*¹, A Moses², A Corbett³, G Phiri², W Kumwenda², N Mkandwire², J Chintedze², M Hosseinipour^1,2, F Stanczyk⁴, and A Kashuba³