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Publications

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Carroll MJ, Mauldin RV, Gromova AV, Singleton SF, Collins EJ, and Lee AL, Evidence for dynamics in proteins as a mechanism for ligand dissociation, Nat. Chem. Biol. (2012), in press.

Zhang J, Petit CM, King DS, and Lee AL,  Phosphorylation of a PDZ domain extension modulates binding affinity and interdomain interactions in PSD-95, J. Biol. Chem. (2011), 286, 41776-41785.

Carroll MJ, Gromova AV, Miller KR, Tang H, Wang XS, Tripathy A, Singleton SF, Collins EJ, and Lee AL,  Direct detection of structurally resolved dynamics in a multi-conformation receptor-ligand complex, J. Am. Chem. Soc. (2011), 133, 6422-6428.

Whitley MJ and Lee AL, Exploring the role of structure and dynamics in the function of chymotrypsin inhibitor 2, PROTEINS: Structure, Function, and Bioinformatics (2011), 79, 916-24.

Sapienza PJ, Mauldin RV, and Lee AL, Multi-timescale dynamics study of FKBP12 along the rapamycin and mTOR binding coordinate, J. Mol. Biol. (2011), 405, 378-394.

Zhang J, Sapienza PJ, Ke H, Chang A, Hengel SR, Wang H, Phillips GN, and Lee AL. Crystallographic and NMR evaluation of the impact of peptide binding to the second PDZ domain of PTP1E.  Biochemistry (2010), 49, 9280-9291.

Sapienza PJ and Lee AL.  Using NMR to study fast dynamics in proteins: methods and applications, Curr. Op. Pharmacol. (2010), 10, 723-730.

Boyer JA, Clay CJ, Luce KS, Edgell MH, Lee AL, Detection of native-state non-additivity in double mutant cycles via hydrogen exchange, J. Am. Chem. Soc. (2010), 132, 8010-8019.

Mauldin RV and Lee AL,  NMR study of the role of M42 in the solution dynamics of E. coli dihydrofolate reductase.  Biochemistry (2010), 49, 1606-15.

Petit CM, Zhang J, Sapienza PJ, Fuentes EJ, and Lee AL,  Hidden dynamic allostery in a PDZ domain, Proc. Natl. Acad. Sci. U.S.A. (2009), 106, 18249-18254.

Law AB, Fuentes EJ, and Lee AL, Conservation of side-chain dynamics within a protein family, J. Am. Chem. Soc. (2009), 131, 6322-33.

Mauldin RV, Carroll MJ, and Lee AL, Dynamic dysfunction in dihydrofolate reductase results from antifolate drug binding: modulation of dynamics within a structural state, Structure (2009), 17, 386-394.

Whitley MJ and Lee AL,  Frameworks for understanding long-range intra-protein communication, Current Protein and Peptide Science (2009), 10, 116-127.

Whitley MJ, Zhang J, and Lee AL, Hydrophobic core mutations in CI2 globally perturb fast side-chain dynamics similarly without regard to position, Biochemistry (2008), 47, 8566-8576.

Boyer JA and Lee AL, Monitoring aromatic ps-ns dynamics in proteins via 13C relaxation:  Expanding perturbation mapping of the rigidifying core mutation, V54A, in eglin c, Biochemistry (2008), 47, 4876-4886.

DeRose EF, Clarkson MW, Gilmore SA, Galban CJ, Tripathy A, Havener JM, Mueller GA, Ramsden DA, London RE, and Lee AL*, The solution structure of polymerase μ’s BRCT domain reveals an element essential for its role in nonhomologous end joining, Biochemistry (2007), 46, 12100-12110.

Fuentes EJ, Gilmore SA, Mauldin RV, and Lee AL, Evaluation of energetic and dynamic coupling networks in a PDZ domain protein, Journal of Molecular Biology (2006), 364, 337-351.

Clarkson MW, Gilmore SA, Edgell MH, and Lee AL, Dynamic coupling and allosteric behavior in a non-allosteric protein, Biochemistry (2006), 45, 7693-7699.

 

 

Clarkson MW and Lee AL, Long-range dynamic effects of point mutations propagate through side chains in the serine protease inhibitor eglin c, Biochemistry (2004) 43, 12448-12458.

Ohnishi S, Lee AL, Edgell MH, and Shortle D, Direct demonstration of structural similarity between native and denatured eglin c, Biochemistry (2004) 43, 4064-4070.

Fuentes EJ, Der CJ, and Lee AL, Ligand-dependent dynamics and intramolecular signaling in a PDZ Domain, J. Mol. Biol. (2004), 335, 1105-1115.

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