Labs

Individual Faculty Members' Labs and Research

		Susan Blalock, PhD Research Focus Evaluation of community-pharmacy based programs focused on illness prevention and disease management

		Albert Bowers, PhD Research Focus The synthesis, assessment, and modification of potential therapeutic leads, especially those derived from natural products.

		Kim Brouwer, PharmD, PhD Research Focus Mechanisms of hepatic uptake, translocation and biliary excretion; drug transport; pharmacokinetics; and aberrant gastrointestinal drug absorption phenomena

		Delesha Carpenter, PhD, MSPH Research Focus Interpersonal influence on disease self-management for persons living with chronic illnesses such as arthritis, vasculitis, lupus, diabetes, and asthma.

		Moo Cho, PhD Lab of Pharmaceutical Chemistry Research Focus Adopting chemical approaches to solve biopharmaceutical problems involved in drug delivery, particularly cellular delivery of nucleic acids.

		Drug Disposition Laboratory Research Focus Elucidating the mechanisms that determine the kinetics of drug disposition and action. The lab's current focus is primarily on drug transport phenomena, especially as they relate to drug distribution, elimination and pharmacologic response, how these processes may be affected by disease states, age, patient variables, and pharmacologic/toxicologic interactions.

		Gang Fang, PharmD, MS, Phd ETrUOP Research Program Research Focus Evaluating treatment utilization and comparative treatment effects on patient-centered outcomes in population.

		Joel Farley, PhD Research Focus Evaluation of the public policies used to manage prescription medications, with a particular interest in the effect of Medicaid prescription cost-containment policies on vulnerable populations.

		Roy Hawke, PharmD, PhD Research Focus The study of drug metabolism enzymes (cytochrome P450s) and hepatobiliary transporters to determine their roles in: liver disease pathobiology and drug-induced hepatotoxicity.

		Shawn Hingtgen, PhD Targeted Cellular Therapeutics and Imaging Lab Research Focus Coupling specially engineered stem cell-based delivery of targeted therapeutics and molecular imaging technologies to discover new treatments for incurable brain cancers and other tumors.

		Leaf Huang, PhD Laboratory of Drug Targeting Research Focus Using liposomes and immunoliposomes for drug delivery. Current activities are focused in the development of non-viral vectors for gene (including oligonucleotides) therapy, and receptor mediated drug and vaccine targeting using self-assembled nanoparticles.

		Federico Innocenti Lab Research Focus Identifying human germline genetic variants, using genomic approaches, which will predict clinical cancer outcomes and responses to pharmacological therapies

		Michael Jay, PhD Research Focus The application of pharmaceutical approaches to solve problems related to nuclear imaging and therapy, and the use of radioanalytical approaches to solve problems encountered in the development of novel formulations and drug delivery systems.

		Jian Jin, PhD Research Focus Discovering chemical probes of protein methyltransferases, nonnucleoside inhibitors of DNA methyltransferases, and functionally selective ligands of GPCRs.

		Angela Kashuba, PharmD Research Focus Preclinical and clinical pharmacology and analytical chemistry with the goal of optimizing the prevention and treatment of HIV infection.

		Harold Kohn, PhD Research Focus The delineation of the mechanism of action of clinically approved and emerging drug candidates and in the broad disciplines of drug discovery and target identification and validation.

		Sam Lai, PhD Lai Research Group Research Focus Infectious diseases and drug delivery to and imaging of metastatic tumors

		Andrew Lee, PhD Research Focus Using NMR spectroscopy to study the relationship between protein structure and dynamics and how these respond to perturbations such as binding (natural ligands or drugs) and mutation (evolution)

		Craig Lee, PharmD, PhD Research Focus The role of genomics in the development, progression and treatment of cardiovascular disease, with a focus on eicosanoid metabolism, inflammation and endothelial dysfunction

		Kuo-Hsiung Lee, PhD Natural Products Research Laboratories Research Focus Medicinal chemistry, bioactive natural products, new drug discovery and development, and Chinese medicine.

		Jian Liu, PhD Glycobiology Laboratory Research Focus Identification of polysaccharide-based receptor; structure and specificity of a heparan sulfate-based herpes simplex virus 1 receptor; drug targeting; gene therapy.

		Rihe Liu, PhD The Functional Proteomics Laboratory at School of Pharmacy and Carolina Center for Genome Sciences Research Focus Using in vitro protein selection strategies to address biological problems on a proteome-wide scale.The major tool used in the lab is a novel technique called mRNA display, in which a protein is covalently linked to the 3' end of its own mRNA.

		Mary Paine, PhD, RPh Research Focus Applying a translational research approach, guided by pharmacokinetic and pharmacodynamic modeling and simulation, to address real-world challenges

		Jaya Rao, MD, MHS Research Focus Patient-provider communication and methods for enhancing communication between patients and their health care providers.

		Mary Roth McClurg, PharmD, MHS Research Focus Evaluating the quality of medication use in older adults who reside in the community setting and developing innovative strategies and programs to improve the quality of medication use in this population.

		Betsy Sleath, PhD Research Focus Physician-patient communication about medications and mental health issues, ethnic/racial differences in medication use, and health behavior and medication adherence.

		Scott Singleton, PhD Singleton Research Group Research Focus Understanding the molecular basis for the development and transmission of microbial drug resistance and the discovery and exploitation of new strategies for controlling drug-resistant microorganisms

		Dhiren Thakker, PhD Research Focus Intestinal absorption and disposition of drugs, with emphasis on transport mechanisms, both paracellular and transcellular, and interactions between drug transport and metabolism.

		Tim Wiltshire, PhD Research Focus Linking genes and disease through the use of haplotype-associated mapping. Our major focus is on anxiety and depression and the drugs used to treat them.

		William Zamboni, PhD Research Focus Translational studies of anticancer agents.

		Qisheng Zhang, PhD Research Focus Studying endogenous, small molecule-protein interactions and their downstream signaling.