Technology and Strategies

• Hit generation

  • Assay development, validation, and automation for low and medium throughput screening at UNC (in the Center or collaborator's lab)
  • Knowledge-based focused screening sets built on target-class, structural and computational models
  • Target specific mechanism and/or pharmacophore based design

• Hit to pre-candidate selection

  • Parallel solution-phase synthesis to pursue 2-3 series per target applying multiple objective optimization
  • Structure-driven design where feasible
  • Early dmpk and physical property assessments (external)
  • Early focus on enabling translational medicine to verify mechanistic hypothesis – animal studies enabled with pharmacodynamic read-out of effect on target

• Provision of small molecule reagents

  • Assist in the discovery of FP-ligands and small molecule probes of biological targets and pathways (Request a Tool Compound)