Christina Battista, Ph.D., works alongside the DILI-sim team and researches ways to enhance the understanding of the drug-induced liver injury (DILI) hazard posed by individual molecules through the use of the DILIsym® software. DILIsym is a “middle-out,” multi-scale computational model of DILI, designed to be used during drug development.
Battista received an ORISE fellowship to investigate mechanistic drug safety within the Center for Drug Evaluation and Research (CDER) at the US FDA under the guidance of Darrell Abernethy. She is currently exploring the role of the immune system in DILI with particular emphasis on mechanistic modeling of the adaptive immune system, in hopes of investigating cases of idiosyncratic DILI. She also works on modeling, evaluating, and incorporating new exemplar compounds to be included in future versions of the DILIsym software.
Prior to joining UNC, Battista was a postdoctoral fellow at the Hamner Institutes for Health Sciences. She received her B.S./M.S. from Rochester Institute of Technology and her Ph.D. from North Carolina State University.