Christopher Asquith, Ph.D.

Postdoctoral Research Associate

Christopher Asquith studied at the University of Southampton, U.K. to obtain a BSc in Chemistry. After earning his BSc he completed a MSc in Chemistry working for professor A. Ganesan, including a 3 month placement abroad at the University of Eastern Finland, working on novel asthma targets. He then moved to University College London, for his Ph.D. in Medicinal Chemistry working for S. Hilton. While completing his Ph.D., he worked in close international collaboration with the University of Zurich, Zurich, Switzerland and Zelinsky Institute, Moscow, Russia, investigating novel heterocyclic motifs against FIV/HIV. Asquith continued his interest in innovative ring systems with a short stay at the University of Cyprus, Cyprus working with professor P. Koutentis before joining the Structural Genomics Consortium at the University of North Carolina at Chapel Hill, working on neglected kinase targets with Tim Willson, Ph.D.
  1. The viral Achilles heel: The nucleocapsid protein of HIV/FIV and related lentiviruses as a therapeutic target. (2016) Asquith, C. R. M. University College London.
  2. Discovery of Novel ADAM33-MMP Inhibitors using the ZINC Database and Computational Modelling. (2011) Asquith, C. R. M. The University of Southampton.
  1. Asquith, C. R. M.*, Konstantinova, L. S., Tizzard, G. J., Laitinen, T., Cole, S. J., Rakitin, O. A., Hilton, S. T. Exploration of a C-H activated route to access the [1,2]dithiolo[4,3-b]indole-3(4H)-thione core and related derivatives Syn. Lett. (2017Submitted
  2.  Asquith, C. R. M., Laitinen, T.,  Konstantinova, L. S., Poso, A., Rakitin, O. A., Hofmann-Lehmann, R., Hilton, S. T. Investigation of the pentathiepin functionality as an inhibitor of Feline Immunodeficiency Virus (FIV) via a potential zinc ejection mechanism, as a model for HIV infection Chem Med Chem. (2017Submitted
  3. Asquith, C. R. M., Konstantinova, L. S., Laitinen, T., Meli, M. L., Poso, A., Rakitin, O. A.,Hofmann-Lehmann, R., Hilton, S. T. Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism. Chem Med Chem. 2016, 19, 2119-2126
  4. Asquith, C. R. M., Konstantinova, L. S., Laitinen, T., Meli, M. L., Poso, A., Rakitin, O. A.,Hofmann-Lehmann, R., Hilton, S. T. Evaluation of substituted 5-thieno, 5-oxo, 5-imino-1,2,3-dithiazoles derivatives as inhibitors of Feline Immunodeficiency Virus (FIV) via a proposed zinc ejection mechanism, as a model for HIV infection. Chem. Med. Comm. (2016Submitted 1st March 2016 (8 pages fully formatted – full paper).
  5. Asquith, C. R. M., Meli, M. L., Konstantinova, L. S., Laitinen, T., Poso, A., Rakitin, O. A., Hofmann-Lehmann, R., Allenspach, K., Hilton, S. T. Novel fused tetrathiocines as zinc abstractors of the nucleocapsid protein of Feline Immunodeficiency Virus (FIV) as a model of HIV infection. Bioorg. Med. Chem. Lett. 201525, 1352-1355.
  6. Asquith, C. R. M., Meli, M. L., Konstantinova, L. S., Laitinen, T., Peräkylä, M., Poso, A., Rakitin, O. A., Allenspach, K., Hofmann-Lehmann, R., Hilton, S. T., Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection. Bioorg. Med. Chem. Lett. 201424, 2640-2644.
  1. Asquith, C. R. M., Meli, M. L., Konstantinova, L. S., Laitinen, T., Poso, A., Rakitin, O. A., Allenspach, K., Hofmann-Lehmann, R., Hilton, S. T. Viral Achilles heel: The nucleocapsid protein of HIV/FIV and related lentiviruses as a therapeutic target (MEDI 380) – 248th ACS National Meeting, San Francisco, California, August 10-14th, 2015.
  2. Asquith, C. R. M., Meli, M. L., Konstantinova, L. S., Laitinen, T., Poso, A., Rakitin, O. A., Allenspach, K., Hofmann-Lehmann, R., Hilton, S. T. Viral Achilles heel: The nucleocapsid protein of HIV/FIV and related lentiviruses as a therapeutic target (TETR2014_0433-P3.70) – 15th Tetrahedron Symposium, London, June 24-27st, 2014.
  3. Asquith, C. R. M., Konstantinova, L. S., Meli, M. L., Laitinen, T., Poso, A., Rakitin, O. A., Hofmann-Lehmann, R., Allenspach, K., Hilton, S. T. The Viral Achilles Heel: The Nucleocapsid Protein of HIV/FIV and Related Lentiviruses as a Therapeutic Target (Abstract 3) – SET for Britain, Houses of Parliament, London, UK 17th March 2014.
  4. Asquith, C. R. M., Konstantinova, L. S., Meli, M. L., Laitinen, T., Poso, A.,Rakitin, O. A., Hofmann-Lehmann, R., Allenspach, K., Hilton, S. T. The Viral Achilles Heel: The Nucleocapsid Protein of HIV/FIV and Related Lentiviruses as a Therapeutic Target (Abstract 1) – 21st RSC Heterocyclic and Synthesis SymposiumGrasmere 9-13th May 2013.
  1. Asquith, C. R. M., Konstantinova, L. S., Meli, M. L., Laitinen, T., Poso, A., Rakitin, O. A., Hofmann-Lehmann, R., Allenspach, K., Hilton, S. T. The Viral Achilles Heel: The Nucleocapsid Protein of HIV/FIV and Related Lentiviruses as a Therapeutic Target Bloomsbury Symposium, Institute of Education, London, 22nd of May 2014.
  2. Asquith, C. R. M., Meli, M. L., Laitinen, T., Poso, A., Hofmann-Lehmann, R., Allenspach, K., Hilton, S. T. The Viral Achilles Heel: The Nucleocapsid Protein of HIV/FIV and Related Lentiviruses as a Therapeutic Target Research Day, UCL School of Pharmacy, London, 19th April 2013.
  3. Asquith, C. R. M., Meli, M. L., Laitinen, T., Poso, A., Hofmann-Lehmann, R., Allenspach, K., Hilton, S. T. The Viral Achilles Heel: The Nucleocapsid Protein of HIV/FIV and Related Lentiviruses as a Therapeutic Target Bloomsbury Symposium, Royal Veterinary College, London, 16th July 2012.
  1. Asquith, C. R. M. The Viral Achilles Heel: The Nucleocapsid Protein of HIV and Related Lentiviruses as a Therapeutic Target Seminar, University of Cyprus, Nicosia, 2nd of Dec 2015.
  2. Asquith, C. R. M., Konstantinova, L. S., Meli, M. L., Laitinen, T., Poso, A., Rakitin, O. A., Hofmann-Lehmann, R., Allenspach, K., Hilton, S. T. The Viral Achilles Heel: The Nucleocapsid Protein of HIV/FIV and Related Lentiviruses as a Therapeutic Target Bloomsbury Symposium, Institute of Education, London, Research Day, UCL School of Pharmacy, London, 19th of Sept 2014.
  3. Asquith, C. R. M., Konstantinova, L. S., Meli, M. L., Laitinen, T., Poso, A., Rakitin, O. A., Hofmann-Lehmann, R., Allenspach, K., Hilton, S. T. The Viral Achilles Heel: The Nucleocapsid Protein of HIV/FIV and Related Lentiviruses as a Therapeutic Target Bloomsbury Symposium, School of Oriental and African Studies, London, 6th of June 2013.
  • Associate Member of the Royal Society of Chemistry (AMRSC)
  • Member of Science and the Chemical Industry (SCI)
  • Member of the American Chemical Society (ACS)