Faculty Profile Page

Overview

The Singleton Laboratory is interested in understanding the molecular basis for the develoment and transmission of microbial drug resistance and the discovery and exploitation of new strategies for controlling drug-resistant microorganisms.  We develop and adapt synthetic chemistry and synthetic biology methods to provide new molecular tools – both biologically active small molecules and innovative platforms – for hypothesis-driven biological research and pharmaceutical discovery.  This important foundation of our program offers both chemically-oriented and biologically-oriented researchers new opportunities for the development of integrated, multi-disciplinary knowledge and technologies.

Tools

chemical synthesis
synthetic biology
combintorial biochemistry
molecular biophysics
high-throughput screening

To Study

synthetic nucleotide analogs, designed peptides, organometallic complexes
DNA repair and recombination related to drug resistance
genomic approaches for revealing antibacterial drug targets
designed genetic selections for directed evolution of unnatural enzymes

To Understand

molecular mechanisms related to the evolution of drug resistance
protease inhibitor resistance in human viruses

To Discover

new antimicrobial targets and strategies
new paradigms for antimicrobial drug development
new lead compounds via HTS
new macromolecular therapeutics
new enzymes

• Research
• Publications
• Lab Life
• UNC.edu
• UNC Pharmacy

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