UNC School of Pharmacy

Publications

Kuo-Hsiung Lee PhD
Kenan Professor
Medicinal Chemistry and Natural Products

Office
UNC School of Pharmacy
Natural Products Research Laboratories
CB # 7360
Beard Hall, Room # 315
Chapel Hill, NC 27599-7360

Email
khlee@unc.edu

Phone
919-962-0066

Fax
919-966-3893

 

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Publications

Examples of recent publications selected from a total of more than 570 articles.

  1. K. H. Lee and Z. Xiao, “Antitumor Agents 229. Lignans in Treatment of Cancer and Other  Diseases,” Phytochemistry Reviews, 2, 341-362 (2004).
  2.  K. H. Lee, “Antitumor Agents 231 and Anti-AIDS Agents 59. Current Developments in the Discovery and Design of New Drug Candidates from Plant Natural Product Leads,” J. Nat. Prod., 67, 273-283 (2004).
  3.  Z. Xiao, K.F. Bastow, J.R. Vance, R. Sidwell, M.S. Chen, Q. Shi and K. H. Lee, "Antitumor Agents. 234. Design, Synthesis and Biological Evaluation of Novel 4β-[(4”-Benzamido)-Amino]-4’-O-Demethyl-Epipodophyllotoxin Derivatives", J. Med. Chem., 47, 5140-5148 (2004).
  4. X. Wang, K.F. Bastow, C.M. Sun, Y.L. Lin, H.J. Yu, M.J. Don, T.S. Wu, S. Nakamura, and K. H. Lee, “Antitumor Agents. 239. Isolation, Structure Elucidation, Total Synthesis, and Anti-Breast Cancer Activity of Neo-tanshinlactone from Salvia miltiorrhiza,” J. Med. Chem., 47, 5816-5819 (2004). 
  5.  L. Xie, D. Yu, C. Wild, G. Allaway, and K. H. Lee, “Anti-AIDS Agents 52. Synthesis and Anti-HIV Activity of Hydroxymethyl (3’R, 4’R)-3’, 4’-Di-O-(S)-camphanoyl-(+)cis-khellactone (DCK) Derivatives,” J. Med. Chem., 47, 756-760 (2004).
  6.  D. Yu, C.H. Chen, A. Brossi, and K. H. Lee, “Anti-AIDS Agents. 60. Substituted 3’R,4’R-Di-O-(-)-Camphanoyl-2’,2’-dimethyldihydropyrano[2,3-f]chromone (DCP) Analogues as Potent Anti-HIV Agents, J. Med. Chem., 47, 4072-4082 (2004).
  7. K. Nakagawa-Goto, M.K. Jung, E. Hamel, C.C. Wu, K.F. Bastow, A. Brossi, S. Ohta, and K. H. Lee, “Antitumor Agents 238. Anti-tubulin and In Vitro Cytotoxic Effects of N-Substituted Allocolchinoids,” Heterocycles, 65, 541-550 (2005).
  8. K. H. Lee and Z. Xiao, “Antitumor Agents 240. Podophyllotoxins and Analogs,” in G.M. Cragg, D.G.I. Kingston, and D.J. Newman, Eds., Antitumor Agents from Natural Products, Taylor & Francis: New York, Chapter 5, 71-87 (2005).
  9. K. Nakagawa-Goto, K.F. Bastow, J.H. Wu, H. Tokuda, and K. H. Lee, “Antitumor Agents 244 and Cancer Preventive Agents 4. Total Synthesis and Bioactivity of Unique Flavone Desmosdumotin B and Its Analogs,” Bioorg. Med. Chem. Lett., 15, 3016-3019 (2005).
  10. K. H. Lee, H. Itokawa, and M. Kozuka, “Asian Herbal Products: The Basis for Development of High-Quality Dietary Supplements and New Medicines,” in J. Shi, C.T. Ho, and F. Shahidi, Eds., Asian Functional Foods, pp. 21-72, Marcel Dekker/CRC Press: Boca Raton, FL (2005).
  11.  L. Huang, X. Yuan, D. Yu, K. H. Lee, and C.H. Chen, “Mechanism of Action and Resistant Profile of Anti-HIV-1 Coumarin Derivatives,” Virology, 332, 623-628 (2005).
  12. H. Itokawa, X. Wang, and K. H. Lee, “Homoharringtonine and Related Compounds,” in G.M. Cragg, D.G.I. Kingston, and D.J. Newman, Eds., Antitumor Agents from Natural Products, Taylor & Francis: New York, Chapter 4, 47-70 (2005).
  13. D. Yu, S.L. Morris-Natschke, C. Wild, G. Allaway, and K. H. Lee, “Anti-AIDS Agents 64. The Discovery of Maturation Inhibitors and Their Potential in the Therapy of HIV,” Expert Opinion In Investigational Drugs, 14, 681-693 (2005).
  14.  M. Suzuki, Y. Li, P.C. Smith, J.A. Swenberg, D.E. Martin, S.L. Morris-Natschke, and K. H. Lee, “Anti-AIDS Agents 65: Investigation of the In Vitro Oxidative Metabolism of 3’,4’-Di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) Derivatives as Potent Anti-HIV Agents, Drug Metabolism and Disposition, 33, 1588-1592 (2005).
  15. Z. Zou, Y. Yi, H. Wu, X. Yao, L. Du, J. Wu, C.C. Liaw, and K. H. Lee, “Intercedensides D-I, Six New Cytotoxic Triterpene Glycosides from the Sea Cucumber Mensamaria intercedens Lampert,” J. Nat. Prod., 68, 540-546 (2005).
  16. N. Tanaka, M. Okasaka, Y. Ishimaru, Y. Takaishi, M. Sato, M. Okamoto, T. Oshikawa, S.U. Ahmed, L.M. Cosentino, and K. H. Lee, “Biyouyanagin A, an Anti-HIV Agent from Hypericum chinense var. salicifolium,” Org. Lett., 7, 2997-2999 (2005).
  17. K. H. Lee, “Recent Advances in the Discovery & Development of Plant-derived Chemotherapeutic Agents,” Int’l J. Applied Sci. and Engineering, 3, 3: 151-155 (2005).
  18. L. Lin and K. H. Lee, “Antitumor Agents 241. Structure-Activity Relationships of Curcumin and Its Analogs with Different Biological Activities,” Studies in Natural Products Chemistry, 33, 785-812 (2006).
  19. D. Yu and K. H. Lee, “Anti-AIDS Agents 63. Recent Progress and Prospects on Plant-derived Anti-HIV Agents and Analogs,” in X.T. Liang and W.S. Fang, Eds., Medicinal Chemistry of Bioactive Natural Products, John Wiley & Sons, Inc., Hoboken, NJ, chapter 9, pp. 357-398 (2006).
  20.  L. Lin, Q. Shi, C.Y. Su, C.C.Y. Shih, and K. H. Lee, “Antitumor Agents 247. New 4-Ethoxycarbonylethyl Curcumin Analogs as Potential Antiandrogenic Agents,” Bioorg.  Med. Chem., 14,  2527-2534 (2006).
  21.  L. Huang, P. Ho, K. H. Lee, and C.H. Chen, “Synthesis and Anti-HIV Activity of Bi-functional Betulinic Acid Derivatives,” Bioorg. Med. Chem.,14, 2279-2289 (2006).