UNC School of Pharmacy

Research Highlights

Kuo-Hsiung Lee PhD
Kenan Professor
Medicinal Chemistry and Natural Products

Office
UNC School of Pharmacy
Natural Products Research Laboratories
CB # 7360
Beard Hall, Room # 315
Chapel Hill, NC 27599-7360

Email
khlee@unc.edu

Phone
919-962-0066

Fax
919-966-3893

 

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Research Highlights

The following example bioactive compounds discovered by the NPRL are currently in
clinical trials or preclinical studies:

  1. GL-331, a synthetic etoposide analog developed in the NPRL, is in Phase II clinical trial as an anticancer drug.
  2.  PA-457 (DSB), a modified triterpene natural product, licensed to Panacos Pharmaceuticals, Inc., has succeeded in Phase IIa Anti-AIDS clinical trials. Clinical trials for Phase IIb are currently ongoing. Phase III clinical trials are currently under planning.  PA-457 is a first-in-class maturation inhibitor.
  3. Novel curcumin analogs discovered and developed in the NPRL, were licensed to AndroScience Corporation of San Diego, CA for preclinical studies as anti-prostate cancer agents. Planning for Phase I clinical trials is in progress.
  4. PA-344B, a modified coumarin-bearing natural product DCK, inhibits HIV reverse transcription by a novel mechanism that appears to differ from currently available non-nucleoside RT inhibitors. Preclinical trials of PA-344B are continuing under license to Panacos Pharmaceuticals, Inc.