• Lab Description
• Research Highlights
• Examples of Recent Publications & Patents

Examples of Recent Publications & Patents

Examples of Recent Publications & Patents: selected from more than 650 articles & 70 patents

1. K.H. Lee, "Antitumor Agents 231 and Anti-AIDS Agents 59. Current Developments in the Discovery and Design of New Drug Candidates from Plant Natural Product Leads," J. Nat. Prod., 67, 272-283 (2004) and literature cited therein.
2. L. Wei, A. Brossi, R. Kendall, K.F. Bastow, S.L. Morris-Natschke, Q. Shi and K.H. Lee, “Antitumor Agents 251: Synthesis, Cytotoxic Evaluation, and Structure-Activity Relationship Studies of Phenanthrene-based Tylophorine Derivatives (PBTs) as a New Class of Antitumor Agents,” Bioorg. Med. Chem., 14, 6560-6569 (2006).  Most Cited Paper 2006-2009 Award from BMC
3. K. Qian, D. Yu, C.H. Chen, L. Huang, S.L. Morris-Natschke, T.J. Nitz, K. Salzwdedl, M. Reddick, G.P. Allaway, and K.H. Lee, “Anti-AIDS Agents 78. Design, Synthesis, Metabolic Stability Assessment, and Antiviral Evaluation of Novel Betulinic Acid Derivatives as Potent Anti-human Immunodeficiency Virus (HIV) Agents,” J. Med. Chem., 52, 3248-3258 (2009).
4. Q. Shi, C.Y. Shih, and K.H. Lee, “Antitumor Agents 265. Novel Anti-Prostate Cancer Curcumin Analogs That Enhance Androgen Receptor Degradation,” Anti-Cancer Agents in Medicinal Chemistry, 9, 904-912 (2009).
5. K.H. Lee, X.H. Wang, K.F. Bastow, and T.S. Wu, "Neo-tanshinlactone and Analogs as Potent and Selective Anti-breast Cancer Agents," US Patent No. 20050250751: Issued 11/10/2005.

Selected Papers

1.       K. H. Lee and Z. Xiao, “Antitumor Agents 229. Lignans in Treatment of Cancer and Other Diseases,” Phytochemistry Rev., 2, 341-362 (2004).

2.       K. H. Lee, “Antitumor Agents 231 and Anti-AIDS Agents 59. Current Developments in the Discovery and Design of New Drug Candidates from Plant Natural Product Leads,” J. Nat. Prod., 67, 273-283 (2004).

 3.       Z. Xiao, K.F. Bastow, J.R. Vance, R. Sidwell, M.S. Chen, Q. Shi and K. H. Lee, "Antitumor Agents 234. Design, Synthesis and Biological Evaluation of Novel 4β-[(4”-Benzamido)-Amino]-4’-O-Demethyl-Epipodophyllotoxin Derivatives", J. Med. Chem., 47, 5140-5148 (2004).

 4.       X. Wang, K.F. Bastow, C.M. Sun, Y.L. Lin, H.J. Yu, M.J. Don, T.S. Wu, S. Nakamura, and K. H. Lee, “Antitumor Agents 239. Isolation, Structure Elucidation, Total Synthesis, and Anti-Breast Cancer Activity of Neo-tanshinlactone from Salvia miltiorrhiza,” J. Med. Chem., 47, 5816-5819 (2004).

 5.       L. Xie, D. Yu, C. Wild, G. Allaway, and K. H. Lee, “Anti-AIDS Agents 52. Synthesis and Anti-HIV Activity of Hydroxymethyl (3’R, 4’R)-3’, 4’-Di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) Derivatives,” J. Med. Chem., 47, 756-760 (2004).

 6.       D. Yu, C.H. Chen, A. Brossi, and K. H. Lee, “Anti-AIDS Agents. 60. Substituted 3’R,4’R-Di-O-(-)-Camphanoyl-2’,2’-dimethyldihydropyrano[2,3-f]chromone (DCP) Analogues as Potent Anti-HIV Agents, J. Med. Chem., 47, 4072-4082 (2004).

 7.       C.Y. Li, C.H. Lin, C.C. Wu, K. H. Lee, and T.S. Wu, “Efficient ¹H Nuclear Magnetic Resonance Method for Improved Quality Control Analyses of Ginkgo Constituents,” J. Agr. Food. Chem., 52, 3721-3725 (2004).

 8.       Y. Kashiwada, M. Sekiya, Y. Ikeshiro, T. Fujioka, N.R. Kilgore, C.T. Wild, G.P. Allaway, and K. H. Lee, “3-O-Glutaryl-dihydrobetulin and Related Monoacyl Derivatives as Potent HIV Agents,” Bioorg. Med. Chem. Lett., 14, 5851-5853 (2004).

 9.       K. H. Lee and Z. Xiao, “Antitumor Agents 240. Podophyllotoxins and Analogs,” in G.M. Cragg, D.G.I. Kingston, and D.J. Newman, Eds., Antitumor Agents from Natural Products, Taylor & Francis: New York, Chapter 5, 71-87 (2005).

 10.      L. Huang, X. Yuan, D. Yu, K. H. Lee, and C.H. Chen, “Mechanism of Action and Resistant Profile of Anti-HIV-1 Coumarin Derivatives,” Virology, 332, 623-628 (2005).

 11.      D. Yu, C. Wild, D. Martin, S.L. Morris-Natschke, C. Chen, G. Allaway, and K. H. Lee, “Anti-AIDS Agents 64. The Discovery of a Class of Novel HIV-1 Maturation Inhibitors and Their Potential in the Therapy of HIV,” Expert Opin. Inv. Drugs, 14, 681-693 (2005).

 12.      Z. Zou, Y. Yi, H. Wu, X. Yao, L. Du, J. Wu, C.C. Liaw, and K. H. Lee, “Intercedensides D-I, Cytotoxic Triterpene Glycosides from the Sea Cucumber Mensamaria intercedens Lampert,” J. Nat. Prod., 68, 540-546 (2005).

 13.      N. Tanaka, M. Okasaka, Y. Ishimaru, Y. Takaishi, M. Sato, M. Okamoto, T. Oshikawa, S.U. Ahmed, L.M. Cosentino, and K. H. Lee, “Biyouyanagin A, an Anti-HIV Agent from Hypericum chinense var. salicifolium,” Org. Lett., 7, 2997-2999 (2005).

 14.      H.F. Chen, B.T. Fan, C.Y. Zhao, L. Xie, C.H. Zhao, T. Zhou, K. H. Lee, and G. Allaway, “Computational Studies and Drug Design for HIV-1 Reverse Transcriptase Inhibitors of 3’,4’-Di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) Analogs,” J. Computer-Aided Mol. Design, 19, 243-258 (2005).

 15.      D. Yu and K. H. Lee, “Anti-AIDS Agents 63. Recent Progress and Prospects on Plant-derived Anti-HIV Agents and Analogs,” in X.T. Liang and W.S. Fang, Eds., Medicinal Chemistry of Bioactive Natural Products, John Wiley & Sons, Inc., Hoboken, NJ, Chapter 9, pp. 357-398 (2006).

 16.      D. Yu, Y. Sakurai, C.H. Chen, F.R. Chang, and K. H. Lee, “Anti-AIDS Agents 69. Moronic Acid and Other Triterpene Derivatives as Novel Potent Anti-HIV Agents,” J. Med. Chem., 49, 5462-5469 (2006).

 17.      L. Lin and K. H. Lee, “Antitumor Agents 241. Structure-Activity Relationships of Curcumin and Its Analogs with Different Biological Activities,” Studies in Natural Products Chemistry, 33, 785-812 (2006).

 18.      L. Lin, Q. Shi, A.K. Nyarko, K.F. Bastow, C.C. Wu, C.Y. Su, C.C.Y. Shih, and K. H. Lee, “Antitumor Agents 250. Design and Synthesis of New Curcumin Analogs as Potential Anti-prostate Cancer Agents,” J. Med. Chem., 49, 3963-3972 (2006).

 19.      L. Wei, A. Brossi, R. Kendall, K.F. Bastow, S.L. Morris-Natschke, and K. H. Lee, “Antitumor Agents 251. Synthesis, Cytotoxic Evaluation, and Structure-Activity Relationship Studies of Phenanthrene-Based Tylophorine Derivatives (PBTs) as a New Class of Antitumor Agents,” Bioorg. Med. Chem., 14, 6560-6569 (2006).

 20.      X. Wang, K. Nakagawa-Goto, K.F. Bastow, M.J. Don, Y.L. Lin, T.S. Wu, and K. H. Lee, “Antitumor Agents 254. Synthesis and Biological Evaluation of Novel Neo-tanshinlactone Analogs as Potent Anti-Breast Cancer Agents,” J. Med. Chem., 49, 5631-5634 (2006).

 21.      M. Horiuch, C. Murakami, N. Fukamiya, D. Yu, T.H. Chen, K.F. Bastow, D.C. Zhang, Y. Takaishi, Y. Imakura, and K. H. Lee, “Anti-AIDS Agents 70. Tripfordines A-C, Sesquiterpene Pyridine Alkaloids from Tripterygium wilfordii, and Structure Anti-HIV Activity Relationships of Tripterygium Alkaloids,” J. Nat. Prod., 69, 1271-1274 (2006).

 22.      J. Tatsuzaki, K.F. Bastow, K. Nakagawa-Goto, S. Nakamura, H. Itokawa, and K. H. Lee, “ Antitumor Agents 249. Dehydrozingerone, Chalcone, and Isoeugenol Analogues as In Vitro Anticancer Agents,” J. Nat. Prod., 69, 1445-1449 (2006).

 23.      P.C. Kuo, T.H. Kuo, A.G. Damu, C.R. Su, E.J. Lee, T.S. Wu, R. Shu, C,M. Chen, K.F. Bastow, T.H. Chen, and K. H. Lee, “Physanolide A, a Novel Skeleton Steroid, and Other Cytotoxic Principles from Physalis angulata,” Org. Lett., 8, 2953-2956 (2006).

 24.      P.L. Wu, Y.L. Hsu, T.S. Wu, K.F. Bastow, and K. H. Lee, “Kalanchosides A-C, New Cytotoxic Bufadienolides from the Aerial Parts of Kalanchoe gracilis,” Org. Lett., 8, 5207-5210 (2006).

 25.      A G. Damu, P.C. Kuo, C.R. Su, T.H. Kuo, T.H. Chen, K. F. Bastow, K.H. Lee, and T.S. Wu, “Isolation, Structures, and Structure-Cytotoxic Activity Relationships of Withanolides and Physalins from Physalis angulata,” J. Nat. Prod, 70, 1146-1152 (2007).

 26.      M. Shibano, A. Lin, H. Itokawa, and K.H. Lee, “Separation and Characterization of Active Favonolignans of Silybum marianum by Liquid Chromatography Connected with Hybrid Ion-trap and Time-of-flight Mass Spectrometry (LC-MS/ IT-TOF),” J. Nat. Prod., 70, 1424-1428 (2007).

 27.      D. Yu, S.L. Morris-Natschke, and K.H. Lee, “Anti-AIDS Agent 67. New Developments in Natural Products-based Anti-AIDS Research,” Med. Res. Rev., 27, 108-132 (2007).

 28.      X. Wang, S.L. Morris-Natschke and K. H. Lee, “Antitumor Agents 245. New Developments in the Chemistry and Biology of the Bioactive Constituents of Tanshen,” Med. Res. Rev., 27, 133-148 (2007).

 29.      S. Zhang, L. Wei, K. Bastow, W. Zheng, A. Brossi, K. H. Lee, and A. Tropsha, “Antitumor Agents 252. Application of Validated QSAR Models to Database Mining: Discovery of Novel Tylophorine Derivatives as Potential Anticancer Agents,” J. Computer-Aided Molecular Design, 21, 97-112 (2007).

 30.      L. Wei, Q. Shi, K.F. Bastow, A. Brossi, S.L. Morris-Natschke, K. Nakagawa-Goto, T.S. Wu, S.L. Pan, C.M. Teng, and K. H. Lee, “Antitumor Agents 253. Design, Synthesis and Antitumor Evaluation of Novel 9-Substituted Phenanthrene-based Tylophorine Derivatives as Potential Anticancer Agents,” J. Med. Chem., 50, 3674-3680 (2007).

 31.      K. Nakagawa-Goto, T.H. Chen, C.Y. Peng, K.F. Bastow, J.H. Wu, and K.H. Lee, “Antitumor Agents 259. Designs, Sytheses and Structure-Activity Relationship Study of Desmosdumotin C Analogs,” J. Med. Chem., 50, 3354-3358 (2007).

 32.      A.S. Lin, K. Nakagawa-Goto, F.R. Chang, D. Yu, S.L. Morris-Natschke, C.C. Wu, S.L. Chen, Y.C. Wu and K.H. Lee, “First Total Synthesis of Protoapigenone and its Analogs as Potent Cytotoxic Agents,” J. Med. Chem., 50, 3921-3927 (2007).

 33.      P.C. Kuo, Y.C. Shen, M.L Yang, S.H. Wang, T.D. Thang, N.X. Dung, P.O. Chiang, K.H. Lee, E.J. Lee and T.S. Wu “Crotonkinins A and B and Related Diterpenoids from Croton tonkinensis as Antiinflammatory and Antitumor Agents,” J. Nat. Prod., 70,1906-1909 (2007).

 34.      L. Wei, A. Brossi, S.L. Morris-Natschke, K.F. Bastow, and K. H. Lee, “Antitumor Agents 248. Chemistry and Antitumor Activity of Tylophorine-related Alkaloids,” Studies in Natural Product Chemistry (Bioactive Natural Products), Ed. Atta-ur-Rahman, Elsevier, New York, Vol. 34, pp. 3-34 (2008).

 35.      L. Xie, H.Guo, H. Lu, X.Zhuang, A.Zhang, G.Wu, J.Ruan, T.Zhou, D.Yu, K.Qian, K.H.Lee and S.Jiang, “Development and Preclinical Studies of Broad-spectrum Anti-HIV Agent (3′R,4′R)-3-Cyanomethyl-4-methyl-3′,4′-di-O-(S)-camphanoyl -(+)-cis-khellactone (3-Cyanomethyl-4-methyl-DCK),” J. Med. Chem., 51, 7689-7696 (2008).

 36.      K. Nakagawa-Goto, K.F. Bastow, T.H. Chen, S.L. Morris-Natschke and K.H. Lee, “Antitumor Agents 260. New Desmosdumotin B Analogs with improved in Vitro Anticancer Activity,” J. Med. Chem., 51, 3297-3303 (2008).

 37.      Y. Usami, Y.N. Liu, A.S. Lin, M. Shibano, T. Akiyama, H. Itokawa, S. Morris-Natschke, K. Bastow, R. Kasai and K.H. Lee, “Antitumor Agents 261. 20(S)-Protopanaxadiol and 20(S)-Protopanaxatriol as Anti-angiogenic Agents and Total Assignment of ¹H – NMR Spectra,” J. Nat. Prod., 71, 478-481 (2008).

 38.      H. Itokawa, S.L. Morris-Natschke, T. Akiyama, and K.H. Lee, “Antitumor Agents 263 and Anti-AIDS Agents 74. Plant-Derived Natural Products Research Aimed at New Drug Discovery,” J. Nat. Med., 62, 263-280 (2008).

 39.      J.C. Lin, S.C. Yang, T.M. Hong, S.L. Yu, Q. Shi, L. Wei, H.Y. Chen, P.C. Yang and K.H. Lee, “Phenanthrene-Based Tylophorine-1 (PBT-1) Inhibits Lung Cancer Cell Growth through the Akt and NF-κB Pathways,” J. Med. Chem., 52, 1903-1911 (2009).

 40.      K. Qian, S.L. Morris-Natschke, and K.H. Lee, “Anti-AIDS Agents 75. HIV Entry Inhibitors and Their Potential in HIV Therapy,” Med. Res. Rev., 29, 369-393 (2009).

 41.      K. Qian, T.J. Nitz, D. Yu, G.P. Allaway, S.L. Morris-Natschke, and K.H. Lee, “Anti-AIDS Agents 76. From Natural Product to Clinical Trial – Bevirimat, a Natural Product Derived Anti-AIDS Drug,” In T. Buss and M. Butler, Eds., Natural Product Chemistry for Drug Discovery, for the Royal Society of Chemistry Biomolecular Sciences Series, Chapter 13, pp. 374-391, Merlion Pharmaceuticals Pte Ltd Press, Singapore, 2009.

 42.      K. Qian, D. Yu, C.H. Chen, L. Huang, S.L. Morris-Natschke, T.J. Nitz, K. Salzwdedl, M. Reddick, G.P. Allaway, and K.H. Lee, “Anti-AIDS Agents 78. Design, Synthesis, Metabolic Stability Assessment, and Anti-HIV Evaluation of Novel Betulinic Acid Derivatives as Potent Anti-HIV-1 Agents,” J. Med. Chem., 52, 3248-3258 (2009).

 43.      Y.H. Chang, M.H. Hsu, S.H. Wang, L.J. Huang, K. Qian, S.L. Morris-Natschke, E. Hamel, S.C. Kuo, and K.H. Lee, “Design and Synthesis of 2-(3-Benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one Analogs as Potent Antitumor Agents that Inhibit Tubulin Assembly,” J. Med. Chem., 52, 4883-4891 (2009).

 44.      K.H. Lee, H. Itokawa, T. Akiyama and S.L. Morris-Natschke, “Antitumor Agents 257 and Anti-AIDS Agents 71. Plant-Derived Natural Products Research: Recent Progress in Drug Discovery” Volume 3, pp 690-712, in Wiley Encyclopedia of Chemical Biology, John Wiley & Sons, Hoboken, 2009.

 45.      Q. Shi, C.Y. Shih, and K.H. Lee, “Antitumor Agents 265. Novel Anti-Prostate Cancer Curcumin Analogs that Enhance Androgen Receptor Degradation Activity,” Anticancer Agents Med. Chem., 9, 904-912 (2009).

 46.      Y. Dong, Q. Shi, Y.N. Liu, X. Wang, K.F. Bastow and K.H. Lee, “Antitumor Agents 266. Design, Synthesis and Biological Evaluation of Novel 2-(Furan-2-yl) naphthalene-1-ol derivatives as Potent and Selective Anti-Breast Cancer Agents,” J. Med. Chem., 52, 3586-3590 (2009).

 47.      R.Y. Kuo, K. Qian, S.L. Morris-Natschke and K.H. Lee, “Antitumor Agents 267 and Anti-AIDS Agents 77. Plant-Derived Triterpenoids and Analogues as Antitumor and Anti-HIV Agents,” Nat. Prod. Rep., 26, 1321-1344 (2009).

 48.      X. Yang, Q. Shi, Y.N. Liu, K.F. Bastow, J.C. Lin, P.C. Yang and K.H. Lee, “Antitumor Agents 268. Design, Synthesis and Mechanistic Studies of New 9-Substituted Phenanthrene-Based Tylophorine Analogs as Potent Cytotoxic Agents,” J. Med. Chem., 52, 5262-5268 (2009).