Papers

Papers

Published at UNC-CH

(1)       Soares, J.; Keppler, B.K.; Wang, X.; Lee, K.-H.; Jarstfer, M.B.^* “Tanshinones Inhibit Telomerase Activity by Inactivating hTERT” manuscript in preparation.

(2)       Fu, Y. T.; Keppler, B. R.; Jarstfer, M. B.^* “3,6-Disubstituted Acridine Dimers That Block Telomere-Binding Proteins” manuscript in preparation.

(3)       Legassie, J. D.; Jarstfer, M. B.^* “The SHAPE of Tetrahymena thermophila Telomerase RNA Changes during Catalysis” manuscript in preparation

(4)       Legassie, J. D.; Jarstfer, M. B.^* “Using SHAPE Analysis to Examine Reconstituted Ribonucleoprotein Complexes: The Case of Telomerase” manuscript in preparation

(5)       Cockrel, L; Church F.; Jarstfer, M. B.^* “The Effect of Locked-Nucleic Acids on a Biologically Active G-Quadruplex: A Structure-activity Relationship of the Thrombin Aptamer” submitted to Nucleosides Nucleotides Nucleic Acids.

(6)       Chen, Y; Fender, J; Legassie, J. D.; Jarstfer, M. B.; Bryan, T. M.; Varani, G.^* “Structure of Stem-loop IV of Tetrahymena telomerase RNA” EMBO J, 2006, 25, 3156-3166.

(7)       Keppler B. R.; Jarstfer, M.B.* “A High Throughput Screen for Human Telomere Reverse Transcriptase Interactions with Human Telomerase RNA” Anal. Biochem. 2006, 353, 75-82.

(8)       Keppler, B. R.; Grady, A. T.; Jarstfer, M. B. ^* “The Biochemical Role of the Heat Shock Protein 90 Chaperone Complex in Establishing Human Telomerase Activity” J. Biol. Chem, 2006, 281, 19840-19848.

(9)       Oganesian, L; Moon, I. K.; Bryan, T. M.^*; Jarstfer, M. B.^* “Ciliate telomerase extends a subset of G-quadruplex DNA structures” EMBO J. 2006, 25, 1148–1159.

(10)   Fouche, N.; Keppler, B. R.; Griffith, J. D. ^* Jarstfer M. B. “Direct Visualization of Telomerase by Electron Microscopy” Biochemistry¸2006, 9624-9631.

(11)   Jeffries, C.^*, Perkins, D., Jarstfer, M. "Systematic discovery of the grammar of translational inhibition by RNA hairpins" J. Theor. Biol. 2006, 241, 205-215.

(12)   Legassie, J. D.; Jarstfer, M. B.^* “Telomerase as a DNA-Dependent DNA Polymerase” Biochemistry, 2005, 44, 14191-14201.

(13)   Jeffries, C*; Jarstfer, M. B.; Perkins, D. O. “Folded RNA from an Intron of One Gene Might Inhibit Expression of a Counteracting Gene” In Silico Biol. 2005, 5, 407-413

(14)   Dominick, P. K.; Keppler, B. R.; Legassie, J. D.; Moon, I. K.; Jarstfer, M. B.^*  "Nucleic-Acid Binding Ligands Identify New Mechanisms to Inhibit Telomerase" Bioorg. Med. Chem. Lett. 2004, 14, 3467-3471.

(15)   Keppler, B. K.; Jarstfer, M. B. ^{* “}Inhibition of Telomerase Activity by Preventing Proper Assemblage. Biochemistry 2004, 43 334-343.

(16)   Dominick P. K.; Jarstfer, M. B.^* "A Conformationally Constrained Nucleotide Analog Allows Control of G-Quadruplex DNA Folding" J. Amer. Chem. Soc. 2004, 126, 5050-5051.

Invited Peer-Reviewed Reviews and Methods

 (17)   Legassie, J.D.; Jarstfer, M.B.^* “The Unmasking of Telomerase” Structure, 2006, 14, 1603-1609.

(18)   Moon, I. K.; Jarstfer, M. B.^* “The Structure of Human Telomeric DNA: Human Disease, Therapy, and Biotechnology” in "DNA Structures, Genome Instability and Human Disease" Front. Biosci., 2007, 12, 4595-4620.

(19)   Moon, I. K.; Jarstfer, M. B.^* “Analysis of G-Quadruplex DNA by Native Gel Electrophoresis” in Methods Mol. Biol. accepted.

(20)   Bryan T. M.^*; Jarstfer, M. B.^* "Interrogation of G-Quadruplex-Protein Interactions" Methods. accepted.

Published as Student or Postdoc

(21)   Jarstfer, M.B.; Zhang, D.L.; Poulter, C.D. “Recombinant Squalene Synthase. Synthesis of Non-Head-to-Tail Isoprenoids in the Absence of NADPH” J. Amer. Chem. Soc. 2002, 124, 8834-8845.

(22)   Blagg, B.S.J.; Jarstfer, M.B.; Rogers, D.H.; Poulter, C.D. “Recombinant Squalene Synthase. A Mechanism for the Rearrangement of Presqualene Diphosphate to Squalene" J. Amer. Chem. Soc. 2002, 124, 8846-53.

(23) Jarstfer, M.B.^*; Cech, T.R. “Effects of nucleotide analogs on Euplotes aediculatus telomerase processivity: evidence for product-assisted translocation” Biochemistry, 2002, 41, 151-161.

(24)   Jarstfer, M.B.; Blagg, B.S.J.; Rogers, D.H.; Poulter, C.D. “Biosynthesis of Squalene. Evidence for a Tertiary Cyclopropylcarbinyl Cationic Intermediate in the Rearrangement of Presqualene Diphosphate to Squalene”  J. Amer. Chem. Soc. 1996, 118, 13089-13090.

(25)   Humpf-H.-U.; Berova, N.; Nakanishi, K.; Jarstfer, M.B.; Poulter, C.D. “Allylic and Homoallylic CD Exciton Chirality: A Useful Method for Determining the Absolute Stereochemistry of Natural Products” J. Org. Chem. 1995, 60, 3539-3542.

(26)   Chase, C.E.; Jarstfer, M.B.; Arif, A.M.; West, F.G. “Unexpected and Efficient Photochemical Rearrangement of 6-Hydroxyethylpyran-2-ones to 4-Alkylidene-5,6-dihydropyrans” Tetrahedron Lett., 1995, 36, 8531-8534.

(27)   Mendoza, J.A.; Jarstfer, M.B.; Goldenberg, D.P. “Effects of Amino Acid Replacements on the Reductive Unfolding Kinetics of Pancreatic Trypsin Inhibitor” Biochemistry 1994, 33, 1143-1148.

(28)   Doyle, M.P.; Westrum, L.J.; Protopopova, M.M.; Eismont, M.Y.; Jarstfer, M.B. “Dirhodium(II) Tetraacetate Catalyzed Hydroboration of Alkenes” Mendeleev Commun. 1993, 81-82.

(29)   Burgess, K.; van der Donk, W.A.; Jarstfer, M.B.; Ohlmeyer, M.J. “Further Evidence for the Role of dp-pp Bonding in Rhodium-Mediated Hydroborations” J. Amer. Chem. Soc. 1991, 113, 6139-6144.

(30)   Doyle, M.P.; Brandes, B.D.; Kazala, A.P.; Pieters, R.J.; Jarstfer, M.B.; Waltkins, L.M.; Eagle, C.T. “Chiral Rhodium (II) Carboxamides. “A New Class of Catalysts for Enantioselctive Cyclopropanation Reactions” Tetrahedron Lett. 1990, 31, 6613-6616.