Before 2004

This list contains articles published between 2000 - 2003

225.    Li, S., Tan, Y., Viroonchatapan, E., Pitt, B. R. and Huang, L.  Targeted gene delivery to pulmonary endothelium by anti-PECAM antibody.  Am. Physiol: Lung Cell Mol. Physiol. 278: L504-L511, 2000.

226.    Li, B., Li, S., Tan, Y., Stolz, D.B., Watkins, S., Block, L.H. and Huang, L.  Lyophilization of Cationic Lipid-Protomine-DNA (LPD) Complexes.  J. Pharm. Sci.  89(3): 355-364, 2000.

227.    He, Y., Pimenov, A. A., Nayak, J., Plowey, J., Falo, L., Huang, L.  Intravenous injection of naked DNA encoding secreted flt3 ligand dramatically increases the number of dendritic cells and natural killer cells in vivo.  Human Gene Therapy. 11(4): 547-554, 2000.

228.    Xing, X., Wang, S-C, Zou, Y., Xia, W., Shao, R., Kwong, K.Y., Yu, Z., Zhang, S., Miller, S., Huang. L. and Hung, M-C.  The Ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nature Med. 6(2): 189-195, 2000.

229.    Liang, K., Hoffman, E.P., and Huang, L.  Targeted delivery of plasmid DNA to myogenic cells via transferrin conjugated pepetide nucleic acid (PNA).  Molecular Therapy. 3: 236-243, 2000.

230.    Leone, P. Janson, C.G., Bilianuk, L., Wang, Z., Sorgi, F., Huang, L., Matalon, R., Kaul, R., Zheng, Z., Freese, A., McPhee, S.W., Mee, E., During, M.J. Aspartoacylase gene transfer to the mammalian central nervous system with therapeutic implications for Canavan disease. Ann Neurol. 48:27-38, 2000.

231.    Grandis, J.R., Drenning, S.D., Zeng, Q., Watkins, S.C., Melhem, M.F., Endo, S., Johnson, D.E., Huang, L., He, Y-K and Kim, J.D.  Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell cacinogenesis in vivo. Proc. Natl. Acad. Sci. USA 97: 4227-4232, 2000. PMCID: PMC18206

232.    Hyde, S.C., Southern, K.W., Gileadi, U., Fitzjohn, E.M., Mofford, K.A., Waddell, B.E., Gooi, H.C., Goddard, C.A., Hannavy, K., Smyth, S.E., Egan, J.J., Sorgi, F.L., Huang, L., Cuthbert, A.W., Evans, M.J., Colledge, W.H., Higgins, C.F., Webb, A.K., and Gill, D.R.  Repeat administration of DNA/liposomes to the nasal epithelium of patients with systic fibrosis.  Gene Therapy, 7: 1156-1165, 2000.

233.    Hofman, C. R., Dileo, J. P., Li, Z., Li, S., Huang, L.  Efficient in vivo gene transfer by PCR amplified fragment with reduced inflammatory activity.  Gene Therapy.  8: 71-74, 2001.

234.    Endo, S., Zeng, Q., Burke, N.A., He, Y-K, Melhem., M.F., Watkins, S.F., Lango, M.N., Drenning, S.D., Huang, L., and Grandis, J.R.  TGF-a antisense gene therapy inhibit head and neck squamous cell carcinoma growth in vivo.  Gene Therapy, 7: 1906-1914, 2000.

235.    Rogy, M., Reinisch, W., Beinhauer, B., Pokieser, P., Huang, L.  Transfer of Interleukin-4 and Interleukin-10 in patients with severe inflammatory bowel disease of the rectum. Human Gene Therapy. 11:1731-1741, 2000.

236.    Griesenbach U, Scheid P, Hillery E, de Martin R, Huang L, Geddes DM, Alton EW. Anti-inflammatory gene therapy directed at the airway epithelium. Gene Therapy 7:306-13, 2000.

237.    Lui, V. W. Y., He, Y., Goyal, K. and Huang, L.  Specific down-regulation of HER-2/neu mediated by a chimeric U6 hammerhead ribozyme results in growth inhibition of human ovarian carcinoma.  Molecular Therapy.  3: 169-177, 2001.

238.    Wu, X., He, Y., Falo, L. D., Hui, K. M., and Huang, L.  Regression of human mammary adenocarcinoma by systemic administration of a recombinant gene encoding a Flt3L-TRAIL fusion protein.  Molecular Therapy. 3: 368-374, 2001.

239.    Yang, J., Chen, S., Huang, L., Michalopoulos, G. and Liu, Y.  Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth.  Hepatology. 33: 848-859, 2001. PMCID: PMC1821076

240.    Tan, Y., Liu, F., Li, Z., Li, S. and Huang, L.  Sequential injection of cationic liposome and plasmid DNA effectively transfects the lung with minimal inflammatory toxicity. Molecular Therapy. 3: 673-682, 2001.

241.    Lui, V. W. Y., Falo, L. and Huang, L.  Systemic production of IL-12 naked DNA mediated gene transfer and attenuation of transgene expression in vivo.  J. Gene Med. 3: 384-393, 2001.

242.    Liu, F., Nishikawa, M., Clemens, P.R. and Huang, L.  Transfer of full-length Dmd to the diaphragm muscle of Dmdmdx/mdx mice through systemic administration of plasmid DNA.  Molecular Therapy.  4: 45-51, 2001.

243.    Chesnoy, S., Durand, D., Doucet, J., Stolz, D.B. and Huang, L.  Improved DNA/Emulsion complex stabilized by polyethylene-glycol conjugated phospholipid.  Pharm. Res.  18: 1480-1484, 2001.

244.    Liu, F. and Huang, L.  Improving plasmid DNA-mediated liver gene transfer by prolonging its retention in the hepatic vasculature.  J. Gene Med. 3: 569-576, 2001.

245.    Whitmore, M., Li, S., Falo, Jr., L. and Huang, L.  Systemic administration of LPD prepared with CpG oligonucleotides inhibits the growth of established pulmonary metastases by stimulating innate and acquired antitumor immune responses. Cancer Immunology and Immunotherapy. 50: 503-514, 2001.

246.    Han, Y., Huang, L., Jackson, E., Dubey, R., Gillepsie, G., and Carcillo, J. Liposomal ATP or NAD protects human endothelial cells from energy failure in a cell culture model of sepsis. Research Communications in Molecular Pathology and Pharmacology. 110: 107-116, 2001.

247.    Hortobagyi, G., Ueno, N., Xia, W., Zhang, S., Wolf, J., Putnam, J., Weiden, P., Willey, J., Carey, M., Branham, D., Payne, J., Tucker, S., Bartholomeusz, C., Kilbourn, R., De Jager, R., Sneige, N., Katz, R., Anklesaria, P., Ibrahim, N., Murray, J., Theriault, R., Valero, V., Gershenson, D., Bevers, M., Huang, L., Lopez-Berestein G., Hung M. Cationic liposome-mediated E1A gene transfer to human breast and overian cancer cells and its biological effects:  a phase I clinical trial.  J Clin Oncol 19:3422-3433, 2001.

248.    Lui, V. W. Y., He, Y., Falo, L. and Huang, L.  Systemic administration of naked DNA encoding IL-12 for the treatment of HPV-DNA positive tumor.  Human Gene Therapy. 13: 177-185, 2002.

249.    Chesnoy, S. and Huang, L.  Enhanced cutaneous gene delivery following intradermal injection of naked DNA in a high ionic strength solution.    Molecular Therapy.  1: 57-62, 2002.

250.    Liu, F. and Huang, L. A syringe electrode device for simultaneous injection of DNA and electrotransfer. Molecular Therapy. 5: 323-328, 2002.

251.    Liu, F. and Huang, L. Electric gene transfer to the liver following systemic administration of plasmid DNA. Gene Therapy. 9: 1116-1119, 2002. This paper was highlighted by Nature.com on August 6, 2002.

252.    Liu, F. and Huang, L. Non-invasive gene delivery to the liver by mechanical massage. Hepatology. 35: 1314-1319, 2002.

253.    Ma, Z., Zhang. J., Alber, S., Dileo, J., Negishi, Y., Stolz, D., Watkins, S., Huang, L., Pitt, B., and Li, S. Lipid-mediated delivery of oligonucleotide to pulmonary endothelium. Am. J. of Respiratory Cell and Molecular Biology. 27: 151-159, 2002.

254.    Ueno, NT., Bartholomeusz, C., Xia, W., Anklesaria, P., Bruckheimer EM., Mebel, E. Paul, R., Li, S., Yo, G., Huang, L. and Hung, MC. Systemic gene therapy in human xenograft tumor models by liposomal delivery of the E1A gene. Cancer Research. 62: 6712-6716, 2002.

255.    Tan, Y., Zhang, J. and Huang, L.  Co-delivery of NF-KB decoy-related oligodeoxynucleotide improves LPD-mediated systemic gene transfer. Molecular Therapy. 6: 804-812, 2002.

256.    Chuang, Y-C., Chancellor, M. B., Seki, S., Yoshimura, N., Tyagi, P., Huang, L., Lavelle, J.P., De Groat, W.C., Fraser, M.O.  Intravesical protamine sulfate and potassium chloride as a model for bladder hyperactivity.  Urology. 61:1-7, 2003.

257.    Chesnoy, S., Lee, P., and Huang, L. Intradermal injection of transforming growth factor-b1 gene enhances wound healing in genetically diabetic mice. Pharmaceutical Research. 20: 345-350, 2003.

258.    Fraser, M., Chancellor, M., Tyagi, P., Yokoyama, T., Yoshimura, N., Huang, L., De Groat, W., Chuang, Y. Intravesical liposome administration- a novel treatment for the hyperactive bladder in the rat. Urology. 61:  656-663, 2003.

259.    Dileo, J., Miller, T., Chesnoy, S., and Huang, L. Gene transfer to sub-dermal tissues via a new design of gene gun. Human Gene Therapy. 14: 79-87, 2003.

260.    Li, Z., Ning, W., Wang, J., Choi, A., Lee, P-Y, Tyagi, P., and Huang, L. Controlled gene delivery system based on thermo-sensitive biodegradable hydrogel. Pharmaceutical Research. 20: 884-888, 2003.

261.    Zhang JL., Wilson A., Ma Z., Tang ZL., Satoh E., Mazda O., Huang L., Pitt B., Li S. Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein-Bar virus-based episomal plasmid.  Gene Therapy. 10: 822-826, 2003.

262.    Dileo, J., Banerjee, R., Whitmore, M., Nayak, J., Falo, L., and Huang, L. LPD mediated antigen delivery to antigen presenting cells results in enhanced anti-tumor immune responses. Molecular Therapy.  7: 640-648, 2003.

263.    Lee, P-Y, Li, Z., and Huang, L.  Thermosensitive hydrogel as a TGF-ß1 gene delivery vehicle enhances diabetic wound healing.  Pharmaceutical Research, 20: 1995-2000, 2003.