Before 1997

This list contains articles published between January 1991 and December 1996

91.    Kabalka, G.W., Davis, M.A., Moss, T.H., Buonocore, E., Hubner, K.,Holmberg, E. Maruyama, K. and Huang, L. Gadolinium-labeled liposomes containing various amphiphilic Gd-DTPA derivatives: targeted MRI contrast enhancement agents for the liver. Magn. Reson. Med. 19:406-415, 1991.

92.    Klibanov, A.L., Maruyama, K., Beckerleg, A.M., Torchilin, V.P. and Huang, L. Activity of amphipathic polyethyleneglycol 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target. Biochim. Biophys. Acta. 1062:142-148, 1991.

93.    Kabalka, G.W., Davis, M.A., Holmberg, E., Maruyama, K. and Huang, L. Gadolinium-labeled liposomes containing amphiphilic Gd-DTPA derivatives of varying chain length: targeted MRI contrast enhancement agents for the liver. Magn. Reson. Imag. 9:373-377, 1991.

94.    Maruyama, K., Mori, A., Kennel, S.J., Waalkes, M.V.B., Scherphof, G.L. and Huang, L. Drug delivery by organ-specific immunoliposomes. In: Polymeric Drugs and Drug Delivery Systems, eds., Dunn, R.L. and Ottenbrite, R.M., A.C.S. Symposium Series 469, Amer. Chem. Soc., Washington, D.C., Chapter 24, pp. 275-284, 1991.

95.    Zhou, X., Klibanov, A. and Huang, L. Lipophilic polylysines mediate efficient DNA transfection in mammalian cells. Biochim. Biophys. Acta. 1065:8-14, 1991.

96.    Zhu, Z., Hughes, K.W. and Huang, L. Effects of 5'azacytidine on transformation and gene expression in Nicotiana tabacum. In Vitro Cell. Dev. Biol. 27:77-83, 1991.

97.    Reddy, R., Zhou, F., Huang, L., Carbone, F., Bevan, M. and Rouse, B. pH sensitive liposomes provide an efficient means of sensitizing target cells to class I restricted CTL recognition of a soluble protein. J. Immunol. Methods 141:157-163, 1991.

98.    Liu, D., Mori, A. and Huang, L. Large liposomes containing ganglioside GM1 accumulate effectively in spleen. Biochim. Biophys. Acta. 1066:159-165, 1991.

99.    Klibanov, A.L., Khaw, B.A., Nosiff, N., O'Donnel, S.M., Huang, L., Slinkin, M.A. and Torchillin, V.P. Targeting of macromolecular carriers and liposomes by monoclonal antibodies to myosin heavy chain. Am. J. Physiol. Suppl. 261:60-65, 1991.

100.    Mori, A., Klibanov, A.L., Torchilin, V.P., and Huang, L. Influence of the steric barrier activity of amphipathic poly(ethyleneglycol) and ganglioside GM1 on the circulation time of liposomes and on the target binding of immunoliposomes in vivo. FEBS Lett. 284:263-266, 1991.

101.    Gao, X. and Huang, L. A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem. Biophys. Res. Commun. 179:280-285, 1991.

102.    Maruyama, K., Mori, A., Bhadra, S., Subbiah, M.T.R. and Huang, L. Proteins and peptides bound to long-circulating liposomes. Biochim. Biophys. Acta. 1070:246-252, 1991.

103.    Zhou, F., Rouse, B.T. and Huang, L. An improved method of loading pH-sensitive liposomes with soluble proteins for class I restricted antigen presentation. J. Immunol. Methods 145:143-152, 1991.

104.    Liu, D., Wada, A and Huang, L. Potentiation of the humoral response of intravenous antigen by splenotropic liposomes. Immunol. Lett. 31:177-182, 1992.

105.    Liu, D., Mori, A. and Huang, L. Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes. Biochim. Biophys. Acta. 1104:95-101, 1992.

106.    Wright, S. and Huang, L. Bilayer stabilization of phosphatidylethanolamine by N- biotinylphosphatidylethanolamine. Biochim. Biophys. Acta. 1103:172-178, 1992.

107.    Nair, S., Zhou, F., Reddy, R., Huang, L. and Rouse, B.T. Soluble proteins delivered to dendritic cell via pH sensitive liposomes induce primary CTL responses in vitro, J. Exp. Med. 175:609-612, 1992.

108.    Reddy, R., Zhou, F., Nair, S., Huang, L. and Rouse, B.T. In vivo cytotoxic T lymphocyte induction with soluble proteins administered in liposomes. J. Immunol. 148:1585-1589, 1992.

109.    Litzinger, D.C. and Huang, L. Biodistribution and immunotargetability of ganglioside stabilized dioleoylphosphatidylethanolamine liposomes. Biochim. Biophys. Acta. 1124:179-187, 1992.

110.    Park, Y.S. and Huang, L. Cryoprotective activity of synthetic glycophospholipids and their interactions with trehalose. Biochim. Biophys. Acta. 1124:241-248, 1992.

111.    Liu, D. and Huang, L. Trypsin induced lysis of lipid vesicles: effect of surface charge and lipid composition. Anal. Biochem. 202:1-5, 1992.

112.    Pinnaduwage, P. and Huang, L. Stable target-sensitive immunoliposomes. Biochemistry 31:2850-2855, 1992

113.    Huang, L., Reddy, R., Nair, S.K., Zhou, F., Rouse, B.T. Liposomal Delivery of Soluble-Protein Antigens for Class-I MHC-Mediated Antigen Presentation. Research in Immunology, 143: (2) 192-196, 1992.

114.    Liu, D. and Huang, L. Size homogeneity of a liposome preparation is crucial for liposome biodistribution in vivo. J. Liposome Res. 2:57-66, 1992.

115.    Zhou, X., Klibanov, A. and Huang, L. Improved encapsulation of DNA in pH-sensitive liposomes for transfection. J. Liposome Res. 2:125-139, 1992.

116.    Torchilin, V.P., Klibanov, A.L., Huang, L., O'Donnell, S., Nossiff, N.D. and Khaw, B.A. Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium. FASEB J. 6:2716-2719, 1992.

117.    Steward, M.J., Plautz, G.E., Del Buono, L., Yang, Z.Y., Xu, L., Gao, X., Huang, L., Nabel, E.G. and Nabel, G.J. Gene transfer in vivo with DNA liposome complexes: safety and toxicity in mice. Human Gene Therapy 3:267-275, 1992.

118.    Wright, S.E. and Huang, L. Immunomagnetic particle induced lysis of antibody-conjugated liposomes. J. Liposome Res. 2:257-273, 1992.

119.    Nair, S., Zhou, X., Huang, L. and Rouse, B.T. Class I restricted CTL recognition of a soluble protein delivered by liposomes containing lipophilic polylysines. J. Immunol. Methods. 152:237-243, 1992.

120.    Trubetskoy, V.S., Torchilin, V.P., Kennel, S.J. and Huang, L. Use of N-terminal modified poly-L-lysine-antibody conjugate as a carrier for targeted gene delivery in mouse lung endothelial cells. Bioconjug. Chem. 3:323-327, 1992.

121.    Trubetskoy, V.S., Torchilin, V.P., Kennel, S. and Huang, L. Cationic liposomes enhance targeted delivery and expression of exogenous DNA mediated by N-terminal modified poly-L-lysine-antibody conjugate in mouse lung endothelial cells. Biochim. Biophys. Acta. 1131:311-313, 1992.

122.    Park, Y.S., Maruyama, K. and Huang, L. Some negatively charged phospholipid derivatives prolong the liposome circulation in vivo. Biochim. Biophys. Acta. 1108:257-260, 1992.

123.    Litzinger, D.C. and Huang, L. Amphipathic poly(ethyleneglycol) 5000-stabilized dioleoylphosphatidylethanolamine liposomes accumulate in spleen. Biochim. Biophys. Acta. 1127:249-254, 1992.

124.    Zhou, F., Rouse, B.T. and Huang, L. Induction of cytotoxic T lymphocytes in vivo with protein antigen entrapped in membranous vehicles. J. Immunol. 149:1599-1604, 1992.

125.    Farhood, H., Bottega, R., Epand, R.M. and Huang, L. Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity. Biochim. Biophys. Acta. 1111:239-246, 1992.

126.    Park, Y.S. and Huang, L. Interaction of synthetic glycophospholipids with phospholipid bilayer membranes. Biochim. Biophys. Acta. 1112:251-258, 1992.

127.    Zhou, F., Rouse, B.T. and Huang, L. Prolonged survival of thymoma bearing mice by vaccination with a soluble protein antigen entrapped in liposomes: a model study. Cancer Res. 52:6287-6291, 1992.

128.    Nabel, E.G., Gordon, D., Yang, Z.-Y., Xu, L., San, H., Plautz, G.E., Wu, B.-Y., Gao, X., Huang, L. and Nabel, G.J. Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization. Human Gene Therapy 3:649-656, 1992.

129.    Park, Y.S. and Huang, L. Effect of chemically modified GM1 and neoglycolipid analogs of GM1 on liposome circulation time: evidence supporting the dysopsonin hypothesis. Biochim. Biophys. Acta. 1116:105-114, 1993.

130.    Mori, A., Kennel, S.J. and Huang, L. Immunotargeting of liposomes containing lipophilic antitumor prodrugs. Pharm. Res. 10:507-514, 1993.

131.    Plautz, G.E., Yang, Z.Y., Wu, B., Gao, X., Huang, L. and Nabel, G.J. Immunotherapy of malignancy by in vivo gene transfer into tumors. Proc. Natl. Acad. Sci. USA. 90:4645-4649, 1993.

132.    Babbitt, B., Burtis, L., Dentinger, P., Constantinides, P., Hillis, L., McGirl, B. and Huang, L. Contact-dependent, immunecomplex-mediated lysis of hapten-sensitized liposomes. Bioconjug. Chem. 4:199-205, 1993.

133.    Gao, X. and Huang, L. Cytoplasmic expression of a reporter gene by co-delivery ofT7 RNA polymerase and T7 promoter sequence with cationic liposomes. Nucleic Acids Research 21:2867-2872, 1993.

134.    Zhou, F. and Huang, L. Monophosphoryl lipid A enhances specific CTL induction by a soluble protein antigen entrapped in liposomes. Vaccine 11:1139-1144, 1993.

135.    Nabel, G.J., Nabel, E., Yang, Z.Y., Fox, B., Plautz, G., Gao, X., Huang, L., Shu, S., Gordon, D. and Chang, A.E. Direct gene transfer with DNA-liposome complexes in melanoma: Expression, biologic activity, and lack of toxicity in humans. Proc. Natl . Acad. Sci. USA 90:11307-11311, 1993.

136.    San, H., Yang, Z.-Y., Pompili, V.J., Jaffe, M.L., Plautz, G.E., Xu, L., Felgner, J.H., Wheeler, C.J., Felgner, P., Gao, X., Huang, L., Gordon, D., Nabel, G.J., and Nabel, E.G. Safety and short-term toxicity of a novel cationic lipid formulation for human gene therapy. Human Gene Therapy 4:781-788, 1993.

137.    Park, Y.S. and Huang, L. Distribution within the reticuloendothelial system of liposomes containing lipid A. J. Drug Targeting 1:325-330, 1993.

138.    Zhou, X. and Huang, L. DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action. Biochim. Biophys. Acta. 1189:195-203, 1994.

139.    Zhou, F., Watkins, S.C. and Huang, L. Characterization and kinetics of the MHC class I-restricted presentation of a soluble antigen delivered by liposomes. Immunobiology. 190:35-52, 1994.

140.    Nabel, G.J., Nabel, E.G., Yang, Z., Fox, B.A., Plautz, G.E., Gao, X., Huang, L., Shu, S., Gordon, D., Chang, A.E. Molecular-Genetic Interventions for Cancer. Cold Spring Harbor Symposia on Quantitative Biology, 59: 699-707, 1994.

141.    Litzinger, D.C., Buiting, A.M.J., van Rooijen, N., and Huang, L. Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes. Biochim. Biophys. Acta. 1190:99-107, 1994.

142.    Tari, A.M., Fuller, N., Boni, L.T., Collins, D. Rand, P. and Huang, L. Interactions of liposome bilayers composed of 1,2-diacyl-3-succinylglycerol with protons and divalent cations. Biochim. Biophys. Acta. 1192:253-262, 1994.

143.    Maruyama, K., Okamoto, A., Ishida, O., Kojima, S., Suginaka, A., Huang, L. and Iwatsuru, M. Biodistribution and antitumor effect of adriamycin encapsulated in long-circulating liposomes containing amphipathic polyethyleneglycol or ganglioside GM1. J. Liposome Res. 4:701-723, 1994.

144.    Yao, T. Degli Esposti, S., Huang, L., Aron, R., Spangenberger, A., and Zern, M. Inhibition of carbon tetrachloride-induced liver injury by liposomes containing vitamin E. Am. J. Physiology. 267 (Gastrointest. Liver Physiol. 30): G477-G484, 1994.

145.    Hui, K.M., Sabapathy, Tr.K., Oei, A.A., Singhal, A., and Huang, L. Induction of alloreactive cytotoxic T lymphocytes by intra-splenic immunization with allogeneic class I major histocompatibility complex DNA and DC-chol cationic liposomes. J. Lipos ome Res. 4:1075-1090, 1994.

146.    Caplen, N.J., Gao, X., Hayes, P., Elaswarapu, R, Fisher, G., Kinrade, E., Chakera, A., Schorr, J., Hughes, B., Dorin, J.R., Porteous, D.J., Alton, E.W.F.W., Geddes, D.M., Coutelle, C., Williamson, R., Huang, L., and Gilchrist, C. Gene therapy for cy stic fibrosis in humans by liposome-mediated DNA transfer: the production of resources and the regulatory process. Gene Therapy. 1:139-147, 1994.

147.    Middleton, P.G., Caplen, N.J., Gao, X., Huang, L., Geddes, D.M., and Alton, E.W.F.W. Nasal application of the cationic liposome DC-chol:DOPE does not alter nasal ion transport, lung function or affect bacterial growth. European Respiratory J. 7:442 -445, 1994.

148.    Gao, X., Jaffurs, D., Robbins, P.D., and Huang, L. A sustained, cytoplasmic transgene expression system delivered by cationic liposomes. Biochem. Biophys. Res. Commun. 200:1201-1206, 1994.

149.    Son, K. and Huang, L. Exposure of human ovarian carcinoma to cisplatin transiently sensitizes the tumor cells for liposome mediated gene transfer. Proc. Natl. Acad. Sci. USA 91:12669-12672, 1994.

150.    Nabel, E.G., Yang, Z., Muller, D., Chang A.E., Gao, X., Huang, L., Cho, K.J., Nabel, G.J. Safety and toxicity of catheter gene delivery to the pulmonary vasculature in a patient with metastatic melanoma. Human Gene Therapy, 5:1089-1094, 1994.

151.    Sternberg, B., Sorgi, F. L., and Huang, L. New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy. FEBS Lett. 356:361-366, 1994.

152.    Ricordi, C., Behboo, R., Klibanov, A., Singal, A., Huang, L. Reversal of diabetes by intrapancreatic injection of aminoguanidine liposomes. Transplantation Proceedings, 26(6):3479, 1994.

153.    Mori, A., Kennel, S.J., Waalkes, M.v.B., Scherphof, G.L., and Huang, L. Characterization of organ-specific immunoliposomes for delivery of 3',5' -O-dipalmitoyl-5-fluoro-2'-deoxyuridine in a mouse lung metastasis model. Cancer Chemother. Pharma col. 35:447-457, 1995.

154.    Freisleben, H-J, Bormann, J., Litzinger, D.C., Lehr, F., Rudolph, P., Schatton, W., and Huang, L. Toxicity and biodistribution of liposomes of the main phospholipid from the archaebacterium thermoplasma acidophilum in mice. J. Liposome Res. 5 (1):215-223, 1995.

155.    Maruyama, K., Takizawa, T., Yuda, T., Kennel, S. J., Huang, L., and Iwatsuru, M. Targetability of novel immunoliposomes modified with amphipathic polyethyleneglycols conjugated at their distal terminals to monoclonal antibodies. Biochim. Biophys. A cta, 1234:74-80, 1995.

156.    Caplen, N. J., Alton, Eric W.F.W., Middleton, P.G., Dorin, J. R.,Stevenson, B. J., Gao, X., Durham, S. R., Jeffery, P. K., Hodson, M. E., Coutelle, C., Huang, L., Porteous, D. J., Williamson, R., and Geddes, D. M. Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nature Medicine, 1:39-46, 1995.

157.    Farhood, H., Gao, X., Barsoum, J. and Huang, L. Co-delivery to mammalian cells of a transcriptional factor with cis-acting element using cationic liposomes. Analyt. Biochem. 225:89-93, 1995.

158.    Farhood, H., Serbina, S., and Huang, L. The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer. Biochim. Biophys. Acta. 1235:289-295, 1995.

159.    Hofland, H. and Huang, L. Inhibition of human ovarian carcinoma cell proliferation by liposome-plasmid DNA complex. Biochem. Biophys. Res. Commun. 207 (2):492-507, 1995.

160.    Briscoe, P., Caniggia, I., Graves, A., Benson, B., Huang, L., Tanswell, A.K., and Freeman, B.A. Delivery of superoxide dismutase to pulmonary epithelium via pH-sensitive liposomes. Am. J. Physiol. 268 (Lung Cell Mol. Physiol. 12):L374-L380, 1995.

161.    Nair, S., Buiting, A.M.J., Rouse, R., van Rooijen, N., Huang, L. and Rouse, B.T. Role of macrophages and dendritic cells in primary cytotoxic T lymphocyte responses. International Immunology, 7 (4):679-688, 1995.

162.    Yu, D., Matin, A., Xia, W., Sorgi, F., Huang, L., and Hung, M.-C. Liposome-mediated E1A gene transfer as therapy for ovarian cancers that overexpress HER-2/neu. Oncogene 11:1383-1388, 1995.

163.    Stern, M., Munkonge, F., Caplen, N., Sorgi, F., Huang, L., Geddes, D., and Alton, E. Quantitative fluorescence measurements of chloride secretion in primary airway epithelium from CF and non-CF subjects. Gene Therapy, 2:766-774, 1995.

164.    Caplen, N.J., Kinrade, E., Sorgi, F., Gao, X., Dieter, G., Geddes, D., Coutelle, C., Huang, L., Alton, E. W.F.W., and Williamson, R. In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE . Gene Therapy, 2:603-613, 1995.

165.    Hart, S.L., Mayall, E., Stern, M., Munkonge, F.M., Frost, A., Huang, L., Vasilliou. M., Williamson, R., Alton, E.W.F.W., and Coutelle, C. The introduction of two silent mutations into a CFTR cDNA construct allows improved detection of exogenous mRNA in gene transfer experiments. Human Molec. Genetics. 4(9):1597-1602, 1995.

166.    Huang, L., Farhood, H., Serbina, N., Teepe, A. G., and Barsoum, J. Endosomolytic activity of cationic liposomes enhance the delivery of human immunodeficiency virus-1 trans-activator protein (Tat) to mammalian cells. Biochem. Biophys. Res. Commun., 2 17:761-768, 1995.

167.    Li, S., Khokhar, A.R., Perez-Soler, R., and Huang, L. Improved antitumor activity of cis-Bis-neodecanoato-trans-R,R-1,2- diaminocyclohexaneplatinum (II) entrapped in long circulating liposomes. Oncology Res., 7:611-617, 1995.

168.    Gao, X. and Huang, L. Potentiation of cationic liposome mediated gene delivery by polycations. Biochemistry., 35:1027-1036, 1996.

169.    Huang, L., Son, K., Gao, X., Hages, D., Yang, Y.Y., Holden, S.A., Teicher, B., Kirkwood, J., and Lazo, J.S. Efficient lipofection with cisplatin resistant human tumor cells. Cancer Gene Therapy 3:107-112, 1996.

170.    Lee, R.J., and Huang, L. Folate-targeted, anionic liposome-entrapped polylysine- condensed DNA (LPDII) for tumor cell-specific gene transfer. J. Biol. Chem. 271:8481-8487, 1996.

171.    Mori, A., Wu, S.-P., Han, I., Khokhar, A.R., Perez-Soler, R., and Huang, L. In Vivo antitumor activity of cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) formulated in long-circulating liposomes. Cancer Chemother. Pharmacol. 37:435-444, 1996.

172.    Bedu-Addo, F., Tang, P., Xu, Y., and Huang, L. Effects of polyethyleneglycol chain length and phospholipid acyl chain composition on the interaction of polyethyleneglycol- phospholipid conjugates with phospholipid: Implications in liposomal drug delivery. Pharm. Res. 13:5, 710-717, 1996.

173.    Bedu-Addo, F., Tang, P., Xu, Y., and Huang, L. Interaction of polyethyleneglycol- phospholipid conjugates with cholesterol-phosphatidylcholine mixtures: Sterically stabilized liposome formulations. Pharm. Res. 13:5, 718-724, 1996.

174.    Yang, J.P. and Huang, L. Direct gene transfer to mouse melanoma by intratumor injection of free DNA. Gene Therapy, 3:542-548, 1996.

175.    Xing, X., Matin, A., Yu, D., Xia, W., Sorgi, F., Huang, L., and Hung, M-C. Mutant SV40 large T antigen as a therapeutic agent for HER-2/neu-overexpressing ovarian cancer. Cancer Gene Therapy, 3, 3:168-174, 1996.

176.    Son, K. and Huang, L. Factors influencing the drug sensitization of human tumor cells for in situ lipofection. Gene Therapy, 10, 343-345, 1996.

177.    Mori, A., Duda, E., and Huang, L. Recombinant human tumor necrosis factor: covalently conjugated to long-circulating liposomes. Int. J. Pharm. 131:57-66, 1996.

178.    Bedu-Addo, F.K. and Huang, L. Effect of Martix lipid chain length on liposomes containing cholesterol and ganglioside GM1:Implications in drug delivery. J. Pharm. Sci. 85:714-719, 1996.

179.    Buiting, A.M.J., Zhou, F., Bakker, J.A.J., vanRooijen, N., and Huang, L. Biodistribution of clodronate and liposomes used in the liposome mediated macrophage 'suicide' approach. J. Immuno. Methods. 192:55-62, 1996.

180.    Sorgi, F.L. and Huang, L. Large scale production of DC-Chol liposomes by microfluidization. Int. J. of Pharmaceutics, 144:131-139, 1996.

181.    Liu, F., Yang, J.P., Huang, L. and Liu, D. New cationic lipid formulations for gene transfer. Pharm. Res., 13:1856-1860, 1996.

182.    Liu, F., Yang, J.P., Huang, L. and Liu, D. Effect of non-ionic surfactants on the formation of DNA/emulsion complex and the emulsion-mediated gene transfer. Pharm. Res.13:1642- 1646, 1996.