Drug Efflux Transporter and Metabolizing Enzyme

Drug Efflux Transporter and Metabolizing Enzyme

Maximizing drug absorption from the intestine is a critical goal in human therapeutics.  Although efflux transporters and metabolizing enzymes are recognized as important barriers to intestinal drug absorption, the interplay between these factors is not well studied and is generally not assessed for new drug candidates.  This work endeavors to examine the mechanism behind the interaction of a well-known transporter, P-glycoprotein, with the most important cytochrome P450 enzyme in intestine, CYP3A.  The secondary goal of this project is development of new in vitro models to predict the involvement of these mechanisms in drug-drug interactions in vivo.