| Center for Integrative Chemical Biology and Drug Discovery |
Stephen
V.
Frye
PhD
Research Professor and Director, Center for Integrative Chemical Biology and Drug Discovery |
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Resources and Portfolio
Resources & Portfolio
The Center has been initiated with funding from across the University and a significant contribution from the Cancer Research Fund (recently created by the State legislature). This initial funding and the facilities devoted to the Center will enable:
- 10 medicinal/synthetic chemists – including two research Professor positions
- 5 assay development & compound profiling scientists – one research Professor
- 1 computational/informatics research Professor
- Creation of a UNC compound collection to be held & assayed at the Biomanufacturing Research Institute and Technology Enterprise (BRITE) at NC Central University – a key collaborator for high throughput screening
- Capability to outsource synthetic chemistry to enhance productivity
The CICBDD resources will support progression of 3-5 targets at steady-state with a projected turnover of 2-3 targets per year. Proposals for targets will be reviewed by the Scientific Advisory Board for the Center.
Initial Collaborations
- Oxytocin Receptor Modulation
- RGS12 Inhibitors
- High Content Screening Biosensors
- Mer Tyrosine Kinase Inhibitor