Center for Integrative Chemical Biology and Drug Discovery
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The Center for Integrative Chemical Biology and Drug Discovery was created with the mission of bringing dedicated medicinal chemistry expertise to bear on biological targets of therapeutic relevance under investigation by UNC faculty. Synthetic chemists, assay development and compound profiling scientists will work in the Center and create dedicated, multidisciplinary project teams with other groups on campus in order to progress targets through the drug discovery and development process. FUNDING NEWS: Stephen Frye is awarded NIH Challenge Grant from the National Institute of General Medical Science for Discovery of Small Molecule MBT Domain Antagonists.The primary objective of this research is to develop potent antagonists of methyl-lysine recognition by human and Drosophila MBT domain containing proteins in order to permit exploration of the biological consequences of blocking this recognition in cell based and in vivo models with relevance to normal and disease biology. CICBDD to collaborate on NIH Transformative R01 grant awarded to Dr. Mark Zylka, Asociate Professor of Cell and Molecular Biology, UNC School of Medicine. This research will focus on harnessing particular enzymes found on the membrane of pain-sensing neurons and determining if these enzymes can be used alone or in combination to treat acute and chronic pain. In collaboration with a group headed by Stephen V. Frye, Ph.D. at the Eshelman School of Pharmacy, Zylka will use medicinal chemistry to synthesize “prodrugs,” pharmacologically inactive compounds that convert to the active form of the drug within the body. |
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