Scott Singleton
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Associate Professor
Division: Medicinal Chemistry and Natural Products
UNC Eshelman School of Pharmacy
Division of Medicinal Chemistry and Natural Products
CB # 7568
Beard Hall, Room 324
Chapel Hill, NC 27599-7568
Email: sfs@email.unc.edu
Office: 919-966-7954
Fax: 919-966-0204
Click here to get the full CV
Education
B.A. Chemistry and Biology, Trinity University (San Antonio, TX)
Ph.D. Chemistry, California Institute of Technology (Pasadena, CA), with Peter B. Dervan
NSF Postdoc, Penn State University (State College, PA), with Stephen J. Benkovic
Research Interests
Bio-Organic and Biophysical Chemical Investigations of the Mechanisms DNA Repair, Directed Evolution of Novel Enzymes, Development of Alternate Strategies for Targeting Drug-Resistant Pathogenic Microorganisms
Bio
Scott Singleton is an Associate Professor of Medicinal Chemistry & Natural Products in the School of Pharmacy at The University of North Carolina at Chapel Hill. Prior to his appointment to the faculty of UNC in 2003, Dr. Singleton was an Assistant Professor in the Departments of Chemistry and Biochemistry & Cell Biology at Rice University (1996-2003). Dr. Singleton’s areas of research interest lie at the interface of chemistry and biology, and his NIH-sponsored research program endeavors to understand the molecular basis for the evolution of drug resistance in pathogenic microorganisms. Seeking new opportunities for the development of integrated, multi-disciplinary knowledge and technologies, Dr. Singleton has led efforts to develop and adapt methods of organic chemistry and synthetic biology to provide new molecular tools - both biologically active small molecules and innovative platforms - for hypothesis-driven biological research and pharmaceutical discovery. Dr. Singleton is also an award-winning teacher of Organic Chemistry and Medicinal Chemistry for undergraduate, graduate, and professional students. Dr. Singleton holds B.A. degrees in Chemistry and Biology from Trinity University (San Antonio, TX) and a Ph.D. in Organic Chemistry from the California Institute of Technology. Following his doctoral research with Professor Peter B. Dervan at Caltech, Dr. Singleton was an NSF postdoctoral fellow with Professor Stephen J. Benkovic at Penn State.
- Selected Publications
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Jie Xiao, Andrew M. Lee, Scott F. Singleton:
Direct evaluation of a kinetic model for RecA-mediated DNA-strand exchange: the importance of nucleic acid dynamics and entropy during homologous genetic recombination.
ChemBioChem;
7
8:
1265-1278
().
English
Abstract Available