Kim L. R. Brouwer, PharmD, PhD, is the George H. Cocolas Distinguished Professor and chair of the Division of Pharmacotherapy and Experimental Therapeutics of the UNC Eshelman School of Pharmacy and a professor in the curriculum in toxicology. She received her BS in pharmacy from Oregon State University. Dr. Brouwer completed her PharmD at the University of Kentucky College of Pharmacy in conjunction with a pharmacy residency at the UK Medical Center and a PhD in pharmaceutical sciences/pharmacokinetics. After postdoctoral training (pharmacology/drug metabolism) in the UK College of Medicine, she joined the faculty at the University of North Carolina in 1986 where she served as director of graduate studies for the School of Pharmacy from 1996 to 2004.

Dr. Brouwer directs an NIH-funded research program focused on hepatobiliary drug disposition and development and refinement of in vitro model systems to predict in vivo hepatobiliary disposition, drug interactions, and hepatotoxicity. She has mentored more than eighty-five undergraduate, graduate, and postdoctoral students and published more than 295 research papers, abstracts, and book chapters.

Dr. Brouwer is a co-inventor of B-CLEAR® (U.S. Patent No. 6,780,580), an in vitro method to assess hepatic uptake, excretion, and biliary clearance that correlates with in vivo data. This technology has been exclusively licensed from the University of North Carolina at Chapel Hill to Qualyst, Inc. Dr. Brouwer is a Qualyst founder and chairs the company’s scientific advisory board.

She served as a member of the NIH Pharmacology Study Section from 1998 to 2002 and is a member of the editorial boards for Drug Metabolism and Disposition, Clinical Pharmacology and Therapeutics, and the AAPS Journal. She was elected an AAPS Fellow in 1998, was recipient of the PHRMA Foundation Award in Excellence in Pharmaceutics in 2001, and recently received the inaugural Pharmaceutical Sciences Outstanding Graduate Program Alumni Award and the Paul F. Parker Award from the University of Kentucky.

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Research Interests:
Mechanisms of hepatic uptake, translocation and biliary excretion
Drug transport
Pharmacokinetics
Aberrant gastrointestinal drug absorption phenomena

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Recent Presentations

“Hepatobiliary Transport: Mechanisms, Model Systems and Implications in Drug Development”
Merck Research Laboratories, Westpoint, Pennsylvania, January, 2002.
 
“Hepatobiliary Transport: Mechanisms, Model Systems and Implications for Drug Development”
Janssen Pharmaceutica N.V., Beerse, Belgium, March, 2002.

“Hepatobiliary Transport: Mechanisms, Model Systems and Implications for Drug Development”
3-Dimensional Pharmaceuticals, Exton, Pennsylvania, May, 2002.

“Graduate Student Involvement in Clinical Research”
NIGMS Pharmacological Sciences Training Grants Meeting: What IS Training in the Pharmacological Sciences? Washington, D.C., August, 2002.

“Role of Hepatic Transporters”
Fifth Annual Land O’Lakes Conference on Drug Metabolism/Applied Pharmacokinetics, Merrimac, Wisconsin, September, 2002.

“Principles of Biopharmaceutics and Pharmacokinetics”
FDA Symposium on Controlled Release of Solid Oral Dosage Forms, Rockville, Maryland, September, 2002. 

“Membrane Vesicles and Sandwich-Cultured Hepatocytes as In Vitro Models to Evaluate Drug Transport”
American Association of Pharmaceutical Scientists Workshop on Drug Transport: From the Bench to the Bedside, Invited Symposium Presentation, Atlanta, Georgia, February, 2003

"What Will Be Your Role In The Pharmacy Profession In 2030?  How Will You Get The Training You Need For That Job You Are Dreaming Of?"
Oregon State University College of Pharmacy; Corvallis, Oregon. April, 2003.

"Preparing the Next Generation of Pharmaceutical Scientists: Case Studies of Mechanisms and Model Systems in Hepatobiliary Transport"
Keynote Address, Oregon State University College of Pharmacy Research Retreat; Corvallis, Oregon. April, 2003.

“In Vitro Models for Estimating Hepatobiliary Clearance”
American Association of Pharmaceutical Scientists Workshop on Pharmaceutical Profiling in Drug Discovery for Lead Selection, Invited Symposium Presentation, Whippany, New Jersey, May, 2003.

“Hepatic Transport and Hepatotoxicity: Mechanisms, Model Systems and Implications in Drug Development”
GlaxoSmithKline, Research Triangle Park, North Carolina, May, 2003.

“Use of Sandwich-Cultured Hepatocytes  to Predict Biliary Excretion of Drugs, Evaluate Alterations in Hepatic Drug Transport, and Define Mechanisms of Interaction”
Gordon Research Conference (Drug Metabolism); Plymouth, New Hampshire. July, 2003.

“Membrane Vesicles and Sandwich-Cultured Hepatocytes as In Vitro Models to Evaluate Drug Transport”
14th North American ISSX Meeting, Invited Short Course Speaker, Providence, Rhode Island, October, 2003.

“Use of Sandwich-Cultured Hepatocytes to Evaluate Mechanisms of Hepatic Transport and Hepatotoxicity”
Washington State University College of Pharmacy, Pullman, Washington, November, 2003.

“Role of Transporters in Hepatic Uptake and Clearance”
Drug Metabolism Discussion Group, Research Triangle Park, February, 2004.

“Hepatic Transport Proteins: Model Systems of Hepatobiliary Transport and Relevance in Drug Development”
Keynote Speaker, Transporter Jamboree, Pfizer, Inc., Ann Arbor, Michigan. April, 2004.

"Coordinated Pharm.D. and Ph.D. Programs: Building Bridges from the Bench to the Clinic"
ASPET Teaching Institute, FASEB Annual Meeting, Washington, D.C., April, 2004.

“Isolated Perfused Liver and Hepatocyte Sandwich Culture to Predict Biliary Excretion”
European Federation for Pharmaceutical Sciences Conference on Drug Transporters: Integrative Approaches in ADME Research, Copenhagen, Denmark, April, 2004.

“Application of Pharmacogenetics in Clinical Practice and Therapeutic Drug Monitoring”
Pharmaceutical Sciences World Congress (PSWC2004), Kyoto, Japan, May 2004.

“Role of Transport Proteins in Hepatobiliary Excretion”
8th World Congress on Clinical Pharmacology and Therapeutics (CPT2004), Brisbane, Australia, August, 2004.

“Methods to Study the Functional Effects of Efflux Pumps in Biomembranes”
“Hepatic Transporters”
“Hepatic Cell Model Systems for Studying Hepatobiliary Transport”
“Computational, Cell Culture and Physicochemical Methods in Preclinical Pharmacokinetics” Post-Graduate Course organized by the Finnish Graduate School for Pharmaceutical Research and Graduate School ESPOM, Helsinki, Finland, December, 2004.

“Transporters (Phase III): Outline of Transporters and Role in Human Xenobiotic Processing”
“Human Metabolism of Public Health-Related, Deployment-Related, Industrial and Agricultural Chemicals” Short Course organized by North Carolina State Univeristy, Raleigh, North Carolina, January, 2005.

“In Vitro Models for Estimating Hepatobiliary Clearance”
ADMET-2 Conference, San Diego, California, February, 2005.

“Hepatotoxicity and Drug Transporters”
AAPS Workshop on Drug Transporters in ADME: From the Bench to the Bedside, Parsippany, NJ, March, 2005.

“The Role of Biliary Clearance in Drug Elimination”
37th Annual Pharmaceutics Graduate Student Research Meeting, Lawrence, KS, June 2005.