Kim Brouwer
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Publications: (selected from 105 refereed articles, 157 published abstracts, 5 book chapters).
Brouwer KLR and Thurman RG: Isolated Perfused Liver. Pharm Biotech 8:161-92, 1996.
Booth CL, Brouwer KR and Brouwer KLR: Effect of Multidrug Resistance Modulators on the Hepatobiliary Disposition of Doxorubicin in the Isolated Perfused Rat Liver. Cancer Res 58:3641-3648, 1998.
Pithavala YK, Heizer WD, Parr AF, O’Connor-Semmes RL and Brouwer KLR: Use of the InteliSite Capsule to Study Ranitidine Absorption from Various Sites Within the Human Intestinal Tract. Pharm Res 15:1869-1875, 1998.
Liu X, LeCluyse EL, Brouwer KR, Gan LL, Lemasters JJ, Stieger B, Meier PJ and Brouwer KLR: Biliary Excretion in Primary Rat Hepatocytes Cultured in a Collagen-Sandwich Configuration. Am J Physiol 277(Gastrointest Liver Physiol 40):G12-21, 1999.
Liu X, LeCluyse EL, Brouwer KR, Lightfoot RM, Lee JI and Brouwer KLR: Use of Ca2+ Modulation to Evaluate Biliary Excretion in Sandwich-Cultured Rat Hepatocytes. J Pharmacol Exp Ther 289:1592-1599, 1999.
Liu X, Chism JP, LeCluyse EL, Brouwer KR and Brouwer KLR: Correlation of Biliary Excretion in Sandwich-Cultured Rat Hepatocytes and In Vivo in Rats. Drug Metab Dispos 27:637-644, 1999.
Letrent SP, Pollack GM, Brouwer KR and Brouwer KLR: Effects of a Potent and Specific P-glycoprotein Inhibitor on the Blood-Brain Barrier Distribution and Antinociceptive Effect of Morphine in the Rat. Drug Metab Dispos 27:827-834, 1999.
Aquilante CL, Letrent SP, Pollack GM and Brouwer KLR: Increased Brain P-Glycoprotein in Morphine Tolerant Rats. Life Sci, 66:PL 47-51, 2000.
Fischer JD, Song MH, Suttle AB, Heizer WD, Burns CB, Vargo DL and Brouwer KLR: Comparison of Zafirlukast (Accolate) Absorption After Oral and Colonic Administration in Humans. Pharm Res 17:154-159, 2000.
Xiong H, Turner KC, Ward ES, Jansen PLM and Brouwer KLR: Altered Hepatobiliary Disposition of Acetaminophen Glucuronide in Isolated Perfused Livers from Multidrug Resistance-Associated Protein 2-Deficient TR- Rats. J Pharmacol Exp Ther 295:512-518, 2000.
Ward ES, Pollack GM and Brouwer KLR: Probenecid-Associated Alterations in Valproic Acid Pharmacokinetics in Rats: Can In Vivo Disposition of Valproate Glucuronide Be Predicted from In Vitro Data? Drug Metab Dispos. 28:1433-1439, 2000.
Ward ES, Pollack GM and Brouwer KLR: Probenecid-Associated Alterations in Valproate Glucuronide Hepatobiliary Disposition: Mechanistic Assessment Utilizing Mathematical Modeling. J Pharmacol Exp Ther 297:141-147, 2001.
Chandra P, LeCluyse EL and Brouwer KLR: Optimization of Culture Conditions for Determining Hepatobiliary Disposition of Taurocholate in Sandwich-Cultured Rat Hepatocytes. In Vitro Cellular & Developmental Biology 37:380-385, 2001.
Crews KR, Murthy BP, Hussey EK, Passannante AN, Palmer JL, Maixner W and Brouwer KLR: Lack of Effect of Ondansetron on the Pharmacokinetics and Analgesic Effects of Morphine and Metabolites after Single-Dose Morphine Administration in Healthy Volunteers. Br J Clin Pharmacol 51:309-316, 2001.
Matheney CJ, Lamb MW, Brouwer KLR and Pollack GM: Pharmacokinetic and Pharmacodynamic Implications of P-glycoprotein Modulation. Pharmacother 21:778-796, 2001.
Annaert PP, Turncliff R, Booth CL, Thakker DR and Brouwer KLR: P-glycoprotein-Mediated In Vitro Biliary Excretion in Sandwich-Cultured Rat Hepatocytes. Drug Metab Dispos 29:1277-1283, 2001.
Xiong H, Yoshinari K, Brouwer KLR, and Negishi M: Role of Constitutive Androstane Receptor in the In Vivo Induction of Mrp3 and CYP2B1/2 by Phenobarbital. Drug Metab Dispos 30:918-923, 2002.
Xiong H, Suzuki H, Sugiyama Y, Meier PJ, Pollack GM and Brouwer KLR: Mechanisms of Impaired Biliary Excretion of Acetaminophen Glucuronide After Acute Phenobarbital Treatment or Phenobarbital Pretreatment: Drug Metab Dispos 30:962-969, 2002.
Lee K, Chee N, Brouwer KLR, Thakker DR: Secretory Transport of Ranitidine and Famotidine across Caco-2 Cell Monolayers. J Pharmacol Exp Ther 303:574-580, 2002.
Murthy BR, Pollack GM, and Brouwer KLR. Contribution of Morphine-6-glucuronide to Antinociception Following Intravenous Administration of Morphine to Healthy Volunteers. J Clin Pharmacol 42:569-76, 2002.
Zamek-Gliszczynski MJ, Xiong H, Patel NJ, Turncliff RZ, Pollack GM, and Brouwer KLR: Pharmacokinetics of 5 (and 6)-Carboxy-2',7'-Dichlorofluorescein and Its Diacetate Promoiety in the Liver. J Pharmacol Exp Ther 304: 801-809, 2003.
McRae MP, Brouwer KLR, and Kashuba AK: Cytokine Regulation of P-Glycoprotein. Drug Metab Rev 35:19-33, 2003.
Patel NJ, Zamek-Gliszczynski MJ, Zhang P, Han Y-H, Jansen PLM, Meier PJ, Stieger B, and Brouwer KLR: Phenobarbital Alters Hepatic Mrp2 Function by Direct and Indirect Interactions. Mol Pharm 64:154-159, 2003.
Chandra P. and Brouwer K.L.R.: The Complexities of Hepatic Drug Transport: Current Knowledge and Emerging Concepts. Pharm Res 21:719-735, 2004.
Hoffmaster KA, Turncliff RZ LeCluyse EL, Kim RB, Meier PJ and Brouwer KLR: P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the Hepatobiliary Disposition of a Model Opioid Peptide. Pharm. Res. 21:1294-1302, 2004.
Turncliff RZ, Meier PJ and Brouwer KLR: Effect of Dexamethasone Treatment on the Expression and Function of Transport Proteins in Sandwich-Cultured Rat Hepatocytes. Drug Metab. Dispos. 32:834-839, 2004.
Tian X, Zamek-Gliszczynski MJ, Zhang P and Brouwer KLR: Modulation of Multidrug Resistance-Associated Protein 2 (Mrp2) and Mrp3 Expression and Function with Small Interfering RNA in Sandwich-Cultured Rat Hepatocytes. Mol. Pharmacol. 66:1004-1010, 2004.
Kemp DC and Brouwer KLR: Viability Assessment in Sandwich-Cultured Rat Hepatocytes after Xenobiotic Exposure. Tox. In Vitro. 18:869-877, 2004.
Ghibellini G, Johnson BM, Kowalsky RJ, Heizer WD and Brouwer KLR: A Novel Method for the Determination of Biliary Clearance in Humans. The AAPS Journal 6(4): Article 33 (http://www.aapsj.org/view.asp?art=aapsj060433), 2004.
Hoffmaster KA, Zamek-Gliszczynski MJ, Pollack GM and Brouwer KLR: Hepatobiliary Disposition of the Metabolically Stable Opioid Peptide [D-penicillamine2,5]enkephalin (DPDPE): Pharmacokinetic Consequences of the Interplay Between Multiple Transport Systems. J. Pharmacol. Exp. Ther. 311:1203-1210, 2004.
Kemp DC, Zamek-Gliszczynski MJ and Brouwer KLR: Xenobiotics Inhibit Hepatic Uptake and Biliary Excretion of Taurocholate in Rat Hepatocytes. Toxicol Sci 83:207-214, 2005.
Hoffmaster KA, Zamek-Gliszczynski MJ, Pollack GM and Brouwer KLR: Multiple Transport Systems Mediate the Hepatic Uptake and Biliary Excretion of the Metabolically Stable Opioid Peptide [D-penicillamine2,5]enkephalin. Drug Metab Dispos 33:287-293, 2005.
Annaert P and Brouwer KLR: Assessment of Drug Interactions in Hepatobiliary Transport Utilizing Rhodamine 123 in Sandwich-Cultured Rat Hepatocytes Drug Metab Dispos 33:388-394, 2005.
Zhang P, Chandra P and Brouwer KLR: Role of Glycosylation in Trafficking of Mrp2 in Sandwich-Cultured Rat Hepatocytes. Mol Pharmacol 67:1334-1341, 2005.
Chandra P, Zhang P and Brouwer KLR: Short-Term Regulation of Multidrug Resistance-Associated Protein 3 (Mrp3/MRP3) in Rat and Human Hepatocytes. Am J Physiol Gastrointest Liver Physiol 288:G1252-1258, 2005.
Zamek-Gliszczynski MJ, Hoffmaster KA, Tian X, Zhao R, Polli JW, Humphreys JE, Webster LO, Bridges AS, Kalvass JC and Brouwer KLR: Multiple Mechanisms are involved in the Biliary Excretion of Acetaminophen Sulfate: Role of Mrp2 and Bcrp1. Drug Metab Dispos 33:1158-1165, 2005.
Chandra P, Johnson BM, Zhang P, Pollack GM and Brouwer KLR: Modulation of Hepatic Canalicular or Basolateral Transport Alters Hepatobiliary Disposition of a Model Organic Anion in the Isolated Perfused Rat Liver. Drug Metab Dispos 33:1238-1243, 2005.