The Division of Medicinal Chemistry and Natural Products focuses on discovering new therapeutic agents and targets. Thousands of compounds researched by the UNC Eshelman School of Pharmacy have the potential for therapeutic applications impacting many disease targets, such as enzymes, specific drug receptors, and even the genome.

Roth study points to new uses, unexpected side effects of already-existing drugs

Scientists at the University of North Carolina at Chapel Hill and the University of California, San Francisco have developed and experimentally tested a technique to predict new target diseases for existing drugs.

Lee Study: Pruning Protein Decreases Binding Affinity without Changing Structure

A research team led by Andrew Lee, PhD, has demonstrated that a protein’s function can be changed without modifying its structure, creating a new comprehension of how proteins bind to each other and to drugs.

Chemistry Dean Crimmins Receives ACS Guenther Award

Michael T. Crimmins, senior associate dean for the natural sciences in the College of Arts and Sciences, has been awarded the 2010 Ernest Guenther Award from the American Chemical Society for outstanding achievement in the chemistry of natural products. He holds a joint appointment as a professor in the UNC Eshelman School of Pharmacy.